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AKT (zeige AKT1 Proteine) and 14-3-3 proteins down-regulate the activity of several BCR (zeige BCR Proteine)-associated components, including BTK (zeige BTK Proteine), BLNK (zeige BLNK Proteine) and SYK (zeige SYK Proteine) and also inhibit SYK's interaction with Importin 7 (zeige IPO7 Proteine)
Our results indicate that TRIM25 (zeige TRIM25 Proteine) is associated with cisplatin resistance and 14-3-3sigma-MDM2 (zeige MDM2 Proteine)-p53 (zeige TP53 Proteine) signaling pathway is involved in this process, suggesting targeting TRIM25 (zeige TRIM25 Proteine) may be a potential strategy for the reversal of cisplatin resistance.
Up-regulation of 14-3-3zeta (zeige YWHAZ Proteine) in response to pVHL (zeige VHL Proteine) is important for the recruitment of PI3K (zeige PIK3CA Proteine) to the cell membrane and for stabilization of soluble beta-catenin (zeige CTNNB1 Proteine).
The 14-3-3 family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon (zeige YWHAE Proteine), theta and zeta isoforms could be useful indicators of disease severity.
High urine 14-3-3 expression is associated with Advanced Stage in Patients with Clear Cell Renal Cell Carcinoma (zeige MOK Proteine).
Levels of 14-3-3 protein (zeige YWHAE Proteine) predict poorer radiographic outcomes in inflammatory polyarthritis patients.
Study shows that 14-3-3 zeta (zeige YWHAZ Proteine)/delta is important in the extracellular vesicles mediated induction of colon malignant phenotype, suggesting its role as a potential target for therapeutic interventions.
the effects of cell viability, migration and invasion were mediated in 14-3-3zeta (zeige YWHAZ Proteine)-dependent manner while that of cell apoptosis was mediated in 14-3-3zeta (zeige YWHAZ Proteine)-independent manner.
14-3-3zeta (zeige YWHAZ Proteine) reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen (zeige PCNA Proteine)
phosphorylation of HS1 (zeige EEF1A2 Proteine) tyrosines at positions 222, 378 and 397 was required for transendothelial migration of NK cells.
analysis of phosphorylation-dependent interactions of AQP2 (zeige AQP2 Proteine) with 14-3-3theta; and -zeta
Data show that IkappaB kinase (zeige CHUK Proteine) (IKK (zeige CHUK Proteine)) phosphorylation of the TPL-2 (zeige MAP3K8 Proteine) kinase (TPL-2 (zeige MAP3K8 Proteine)) induces 14-3-3 association with TPL-2 (zeige MAP3K8 Proteine), stimulating its MEK (zeige MDK Proteine) kinase activity, which is essential for TPL-2 (zeige MAP3K8 Proteine) activation of ERK-1 (zeige MAPK3 Proteine)/2.
There is a scaffolding role for 14-3-3theta in assisting the delivery of Cx43 (zeige GJA1 Proteine) and integrin alpha5 to the plasma membrane for the formation of mechanosensitive hemichannels in osteocytes.
14-3-3 negatively regulates the RGC downstream of the PI3-kinase (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway
14-3-3 theta is a new and important regulatory protein (zeige TGFB1 Proteine) in the TLR-2 and TLR-4 (zeige TLR4 Proteine) signaling suppressing the MyD88 (zeige MYD88 Proteine)-dependent pathway
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
14-3-3 protein tau
, 14-3-3 tau
, 14-3-3 theta
, 14-3-3 protein theta
, 14-3-3 protein T-cell
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide
, cerebellar 14-3-3 theta protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 2