three Prime Repair Exonuclease 1 ELISA Kits (TREX1)
Auf finden Sie aktuell 0 three Prime Repair Exonuclease 1 (TREX1) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TREX1 Antikörper (60) und TREX1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 75 TREX1 Produkte verfügbar.
1661, AGS1, AU041952, CRV, DRN3, HERNS, RGD1309596
list all ELISA KIts Gen GeneID UniProt
Human TREX1 TREX1 11277 Q9NSU2
Maus TREX1 TREX1 22040 Q91XB0
Ratte TREX1 TREX1 100049583  

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Weitere ELISA Kits für TREX1 Interaktionspartner

Human three Prime Repair Exonuclease 1 (TREX1) Interaktionspartner

  1. Aicardi-Goutieres syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease (zeige EXO1 ELISA Kits)-independent ORF1p depletion.

  2. Analysis of mRNA expression profiles in breast tumors demonstrates that those with lower Trex1 and higher BLM and EXO1 (zeige EXO1 ELISA Kits) expression levels are associated with poor prognosis

  3. showed that patients with SSc (zeige CYP11A1 ELISA Kits) or SLE have AAb against EphB2 (zeige EPHB2 ELISA Kits), a protein involved in angiogenesis, and THEX1 (zeige ERI1 ELISA Kits), a 3'-5' exoribonuclease involved in histone mRNA degradation.

  4. The expression of TREX1 was closely related to the cytobiology characteristics of osteosarcoma stem cell.

  5. Heterozygous mutations in TREX1 were reported in SLE patients.

  6. This study reviewed that Neurologic Phenotypes Associated with Mutations in TREX1 in patients with Aicardi-Goutieres Syndrome.

  7. Aicardie-Goutieres syndrome is described in a patient with a homozygous p.Arg114His mutation in the TREX1 gene.

  8. CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated.

  9. Aicardi-Goutieres syndrome 1 is caused by mutations in the three prime repair exonuclease 1 gene (TREX1, MIM 606609).

  10. Functional analysis of retinal vasculopathy with cerebral leukodystrophy-associated TREX1 T270 frameshift-mutated fibroblasts showed a prevalent localization of the protein in the cytosol, rather than in the perinuclear region

Mouse (Murine) three Prime Repair Exonuclease 1 (TREX1) Interaktionspartner

  1. Trex1 expression in dendritic cells is essential to prevent breakdown of self-tolerance ensuing from aberrant detection of endogenous DNA.

  2. Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 knockout (Trex1-/-) cells.

  3. Data show that cyclic GMP (zeige NT5C2 ELISA Kits)-AMP (zeige TMPRSS5 ELISA Kits) synthase (cGAS) is essential for all aspects of the autoimmune disease in 3' repair exonuclease (zeige EXO1 ELISA Kits) Trex1 knockout mice.

  4. Dysfunctional dsDNA degradation by TREX1 D18N induces disease in mice that recapitulates many characteristics of human lupus.

  5. DC activation induced by TLR3 (zeige TLR3 ELISA Kits), -4, -7, and -9 ligands also augments Trex1 expression through autocrine IFN-beta (zeige IFNB1 ELISA Kits) production and triggering of the IFN signaling pathway

  6. knocking out the DNA sensor cyclic GMP (zeige NT5C2 ELISA Kits)-AMP (zeige TMPRSS5 ELISA Kits) synthase completely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells.

  7. Spontaneous type I INF (zeige GIF ELISA Kits) dependent cutaneous pathology in TREX1 deficiency illustrates common pathogenetic pathway in chilblain lupus.

  8. Upon proinflammatory stimulation, Trex1(-/-) macrophages increase CD86 (zeige CD86 ELISA Kits), TNF-alpha (zeige TNF ELISA Kits) & IFN-alpha (zeige IFNA ELISA Kits) production, & Ag presentation to CD4 (zeige CD4 ELISA Kits)(+) T cells, but decrease apoptotic T cell clearance. Trex1 is a negative regulator of macrophage inflammatory activation.

  9. Oxidized DNA Is less susceptible to TREX1 degradation; the oxidized base 8-hydroxyguanosine, a marker of oxidative damage in DNA, potentiated cytosolic immune recognition by decreasing its susceptibility to 3' repair exonuclease 1 -mediated degradation

  10. regulates lysosomal biogenesis and interferon (zeige IFNA ELISA Kits)-independent activation of antiviral genes

TREX1 Antigen-Profil

Beschreibung des Gens

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TREX1

  • three prime repair exonuclease 1 (CpipJ_CPIJ012074) Elisa Kit
  • three prime repair exonuclease 1 (Tsp_03749) Elisa Kit
  • three prime repair exonuclease 1 (TREX1) Elisa Kit
  • three prime repair exonuclease 1 (Trex1) Elisa Kit
  • 1661 Elisa Kit
  • AGS1 Elisa Kit
  • AU041952 Elisa Kit
  • CRV Elisa Kit
  • DRN3 Elisa Kit
  • HERNS Elisa Kit
  • RGD1309596 Elisa Kit

Bezeichner auf Proteinebene für TREX1

three prime repair exonuclease 1 , 3' repair exonuclease 1 , 3'-5' exonuclease TREX1 , DNase III , deoxyribonuclease III , three prime exonuclease 1 , trophoblast expressed 1

6045034 Culex quinquefasciatus
10910476 Trichinella spiralis
11277 Homo sapiens
22040 Mus musculus
100049583 Rattus norvegicus
282099 Bos taurus
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