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Human TNFSF10 Protein expressed in Wheat germ - ABIN1323209
Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. in The Journal of clinical endocrinology and metabolism 2013
xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (zeige SSU1 Proteine), presumably owing to PKC activation, as part of the mechanism for RBC (zeige CACNA1C Proteine) switching
Imbalance of the apoptosis pathway, with dysregulation of p73 (zeige TP73 Proteine) and TRAIL, seems to play a role in the oncogenesis of odontogenic tumors
hepatitis B virus (HBV) X protein (HBx) restricts TNFSF10 receptor signaling via macroautophagy/autophagy-mediated degradation of TNFRSF10B/DR5 (zeige TNFRSF10B Proteine), a TNFSF10 death receptor.
TRAIL expression is associated with thyroid hormone (zeige PTH Proteine) levels in vivo and TRAIL expression in peripheral blood mononuclear cells is stimulated by thyroid hormones in vitro.
Antagonistic antibodies against the death receptors demonstrated that Apo2L/TRAIL mediated its apoptotic signals through activation of the TRAIL-R2 in PTHrP expressing breast cancer cells
Co-treatment of carboplatin and autophagy inhibitor chloroquine increased lung tissue infiltration by CD4 (zeige CD4 Proteine)(+), FoxP3 (zeige FOXP3 Proteine)(+) lymphocytes and antigen-specific immune activation. Subsequent ex vivo experiments showed the activation of carboplatin related TRAIL-dependent apoptosis through caspase 8 (zeige CASP8 Proteine) and a synergistic role of miR (zeige MLXIP Proteine)-155 in lung tissue infiltration by CD4 (zeige CD4 Proteine)(+), and FoxP3 (zeige FOXP3 Proteine)(+) lymphocytes.
Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.
Endogenous TRAIL/TRAIL-R-mediated CCL2 (zeige CCL2 Proteine) secretion promotes accumulation of tumor-supportive immune cells in the cancer microenvironment.
Fn14 (zeige TNFRSF12A Proteine).TRAIL can be converted into a highly effective TRAIL oligomer upon binding to TWEAK (zeige TNFSF12 Proteine) which induces lymphoblast apoptosis.
BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 (zeige HLADRB4 Proteine) expression in p53 (zeige TP53 Proteine)-dependent manner and inhibiting NF-kappaB (zeige NFKB1 Proteine) activity.
High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 (zeige TNFRSF10B Proteine) cross-linking and increases antitumour effect against colon cancer cells and xenograft tumors.
Data suggest forkhead box protein O1 (FoxO1 (zeige FOXO1 Proteine)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (zeige FASL Proteine) expression during follicular atresia.
The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.
Data suggest that the CXCL9 (zeige CXCL9 Proteine)-CXCR3 (zeige CXCR3 Proteine) axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.
Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (zeige NOX4 Proteine)/eNOS (zeige NOS3 Proteine)/nitric oxide signaling.
Study reports that loss of the Opg (zeige TNFSF11 Proteine) gene results in deterioration of abdominal aortic aneurysms (AAA (zeige AAAS Proteine)), possibly through involvement of TRAIL in smooth muscle actin (SMA (zeige SMN1 Proteine))-positive cells and myofibroblasts.
PARP1 (zeige PARP1 Proteine) acts as a prominent upstream regulator of high mobility group box 1 (zeige HMGB1 Proteine)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance
Data suggest that Socs3 (suppressor of cytokine signaling 3 (zeige SOCS3 Proteine)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (zeige MAPK8 Proteine)/AP-1 (zeige JUN Proteine) transcription factor signaling.
These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (zeige HSP70 Proteine).
These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald (zeige RDH11 Proteine) burns
TRAIL-deficiency in ApoE (zeige APOE Proteine)(-/-) mice exacerbates nephropathy and insulin (zeige INS Proteine) resistance
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
tumor necrosis factor ligand superfamily member 10
, TNF-related apoptosis inducing ligand
, TNF-related apoptosis inducing ligand-like protein
, Tnf-alpha related apoptosis inducing ligand
, TNF-related apoptosis-inducing ligand 1
, tumor necrosis factor related apoptosis inducing ligand 1
, Apo-2 ligand
, TNF-related apoptosis inducing ligand TRAIL
, chemokine tumor necrosis factor ligand superfamily member 10
, tumor necrosis factor (ligand) family, member 10
, tumor necrosis factor apoptosis-inducing ligand splice variant delta
, tumor necrosis factor-related apoptosis-inducing ligand
, TNF-related apoptosis-inducing ligand