TNFSF10 Proteine (TNFSF10)

Bezeichnung:
Tumor Necrosis Factor (Ligand) Superfamily, Member 10 Proteine (TNFSF10)
Auf www.antikoerper-online.de finden Sie aktuell 73 Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Proteine von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TNFSF10 Antikörper (371) und TNFSF10 Kits (48) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 511 TNFSF10 Produkte verfügbar.
Synonyme:
A330042I21Rik, AI448571, APO-2L, APO2L, CD253, Ly81, TL2, Trail, trail1, xtrail1
alle Proteine anzeigen Gen GeneID UniProt
TNFSF10 8743 P50591
TNFSF10 22035 P50592
Ratte TNFSF10 TNFSF10 246775  

Weitere Synonyme anzeigen

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Am meisten referenzierte TNFSF10 Proteine

  1. Human TNFSF10 Protein expressed in Escherichia coli (E. coli) - ABIN666704 : Janssen, Droin, Lemmens, Pinkoski, Bensinger, Ehst, Griffith, Green, Schoenberger: CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. in Nature 2005 (PubMed)
    Zeige alle 2 Referenzen für 666704

  2. Mouse (Murine) TNFSF10 Protein expressed in Escherichia coli (E. coli) - ABIN2007441 : Wiley, Schooley, Smolak, Din, Huang, Nicholl, Sutherland, Smith, Rauch, Smith: Identification and characterization of a new member of the TNF family that induces apoptosis. in Immunity 1996 (PubMed)
    Zeige alle 2 Referenzen für 2007441

  3. Human TNFSF10 Protein expressed in Escherichia coli (E. coli) - ABIN1047804 : Pitti, Marsters, Ruppert, Donahue, Moore, Ashkenazi: Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. in The Journal of biological chemistry 1996 (PubMed)

  4. Human TNFSF10 Protein expressed in Wheat germ - ABIN1323209 : Borbone, De Rosa, Siciliano, Altucci, Croce, Fusco: Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells. in The Journal of clinical endocrinology and metabolism 2013 (PubMed)

Weitere Proteine zu TNFSF10 Interaktionspartnern

Xenopus laevis Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Interaktionspartner

  1. xTRAIL1 can cause apoptosis, probably mediated through xDR-Ms, in larval red blood cells, but may not kill adult RBCs (zeige SSU1 Proteine), presumably owing to PKC activation, as part of the mechanism for RBC (zeige CACNA1C Proteine) switching

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Interaktionspartner

  1. Co-treatment of carboplatin and autophagy inhibitor chloroquine increased lung tissue infiltration by CD4 (zeige CD4 Proteine)(+), FoxP3 (zeige FOXP3 Proteine)(+) lymphocytes and antigen-specific immune activation. Subsequent ex vivo experiments showed the activation of carboplatin related TRAIL-dependent apoptosis through caspase 8 (zeige CASP8 Proteine) and a synergistic role of miR (zeige MLXIP Proteine)-155 in lung tissue infiltration by CD4 (zeige CD4 Proteine)(+), and FoxP3 (zeige FOXP3 Proteine)(+) lymphocytes.

  2. Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.

  3. Endogenous TRAIL/TRAIL-R-mediated CCL2 (zeige CCL2 Proteine) secretion promotes accumulation of tumor-supportive immune cells in the cancer microenvironment.

  4. Fn14 (zeige TNFRSF12A Proteine).TRAIL can be converted into a highly effective TRAIL oligomer upon binding to TWEAK (zeige TNFSF12 Proteine) which induces lymphoblast apoptosis.

  5. BAY61-3606 sensitizes colon cancer cells to TRAIL-induced apoptosis by up-regulating DR4 (zeige HLADRB4 Proteine) expression in p53 (zeige TP53 Proteine)-dependent manner and inhibiting NF-kappaB (zeige NFKB1 Proteine) activity.

  6. High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 (zeige TNFRSF10B Proteine) cross-linking and increases antitumour effect against colon cancer cells and xenograft tumors.

  7. results suggest that miR (zeige MLXIP Proteine)-223 increases the sensitivity of TNBCSCs to TRAIL-induced apoptosis by targeting HAX-1 (zeige HAX1 Proteine)

  8. The results suggested that miR (zeige MLXIP Proteine)-138 regulates the interferon (zeige IFNA Proteine)-stimulated gene 15 expression by directly targeting the 3' untranslated region of interferon (zeige IFNA Proteine)-stimulated gene 15 and modulates the sensitivity to TRAIL-induced apoptosis.

  9. these results demonstrate that high HOTAIR levels increase the resistance of pancreatic cancer cells to TRAIL-induced apoptosis via epigenetic regulation of DR5 (zeige TNFRSF10B Proteine) expression.

  10. miR (zeige MLXIP Proteine)-661 overexpression sensitized tumors to TRAIL or STS (zeige STS Proteine) induced apoptosis in a xenograft mouse model, and these effects were attenuated by co-expression of CYC1 (zeige CYC1 Proteine).

Pig (Porcine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Interaktionspartner

  1. Data suggest forkhead box protein O1 (FoxO1 (zeige FOXO1 Proteine)) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL and Fas ligand FasL (zeige FASL Proteine) expression during follicular atresia.

  2. The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) Interaktionspartner

  1. Tnfsf10 expression is increased in eosinophilic esophagitis. Tnfsf10(-/-) mice were largely protected from esophageal fibrosis and eosinophilic inflammation.

  2. Diabetes significantly increased OPG (zeige TNFSF11 Proteine) and the OPG (zeige TNFSF11 Proteine)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Proteine) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Proteine)/TRAIL ratio.

  3. TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4 (zeige NOX4 Proteine)/eNOS (zeige NOS3 Proteine)/nitric oxide signaling.

  4. Study reports that loss of the Opg (zeige TNFSF11 Proteine) gene results in deterioration of abdominal aortic aneurysms (AAA (zeige AAAS Proteine)), possibly through involvement of TRAIL in smooth muscle actin (SMA (zeige SMN1 Proteine))-positive cells and myofibroblasts.

  5. PARP1 (zeige PARP1 Proteine) acts as a prominent upstream regulator of high mobility group box 1 (zeige HMGB1 Proteine)-mediated autophagy and maintains a homeostatic balance between apoptosis and autophagy, which provides new insight into the mechanism of TNFSF10 resistance

  6. Data suggest that Socs3 (suppressor of cytokine signaling 3 (zeige SOCS3 Proteine)) plays critical negative role in regulation of Trail expression in endoplasmic reticulum stress in macrophages via Jun N-terminal kinase (zeige MAPK8 Proteine)/AP-1 (zeige JUN Proteine) transcription factor signaling.

  7. These findings indicate that acute fasting enhances TRAIL-mediated liver natural killer cell activity against neoplastic cells through upregulation of heat shock protein 70 (zeige HSP70 Proteine).

  8. These results demonstrated that TRAIL plays a deleterious role in acute kidney injury pathogenesis induced by scald (zeige RDH11 Proteine) burns

  9. TRAIL-deficiency in ApoE (zeige APOE Proteine)(-/-) mice exacerbates nephropathy and insulin (zeige INS Proteine) resistance

  10. Tumor necrosis factor (zeige TNF Proteine)-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.

TNFSF10 Protein Überblick

Protein Überblick

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TNFSF10

  • tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10)
  • TNF-related apoptosis inducing ligand-like (TRAIL-LIKE)
  • tumor necrosis factor (ligand) superfamily, member 10 (tnfsf10)
  • tumor necrosis factor (ligand) superfamily, member 10 (Tnfsf10)
  • A330042I21Rik Protein
  • AI448571 Protein
  • APO-2L Protein
  • APO2L Protein
  • CD253 Protein
  • Ly81 Protein
  • TL2 Protein
  • Trail Protein
  • trail1 Protein
  • xtrail1 Protein

Bezeichner auf Proteinebene für TNFSF10

tumor necrosis factor ligand superfamily member 10 , TNF-related apoptosis inducing ligand , TNF-related apoptosis inducing ligand-like protein , Tnf-alpha related apoptosis inducing ligand , TNF-related apoptosis-inducing ligand 1 , tumor necrosis factor related apoptosis inducing ligand 1 , Apo-2 ligand , TNF-related apoptosis inducing ligand TRAIL , chemokine tumor necrosis factor ligand superfamily member 10 , tumor necrosis factor (ligand) family, member 10 , tumor necrosis factor apoptosis-inducing ligand splice variant delta , tumor necrosis factor-related apoptosis-inducing ligand , TNF-related apoptosis-inducing ligand , TRAIL/APO2L

GENE ID SPEZIES
378894 Gallus gallus
395283 Gallus gallus
100174789 Felis catus
100316914 Xenopus laevis
8743 Homo sapiens
100174780 Canis lupus familiaris
406191 Sus scrofa
22035 Mus musculus
246775 Rattus norvegicus
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