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Urinary DcR2 (zeige CCR6 Proteine) could potentially serve as a novel biomarker for tubulointerstitial injury and may reflect senescence of renal proximal tubular cells in diabetic nephropathy.
Results identified epigenetic inactivation of TNFRSF10C (zeige TNFRSF10C Proteine) and TNFRSF10D in majority of cervical cancer cases.
This study identified TNFRSF10D DNA methylation (zeige HELLS Proteine) status as an independent prognostic biomarker for relapse-free survival and overall mortality in non-metastatic melanoma patients.
The membrane expression of the TRAIL receptors DR4 (zeige HLADRB4 Proteine), DR5 (zeige TNFRSF10B Proteine), DcR1 (zeige TNFRSF10C Proteine) and DcR2 (zeige CCR6 Proteine) is greater in normal endometrium than endometrioid adenocarcinoma (EAC (zeige CYLD Proteine)). The level of the receptors in EAC (zeige CYLD Proteine) is not dependent on grading and staging and does not predict survival.
the results presented here claim for a relevant impact of aberrant methylation of decoy receptors in melanoma and allow to understand how the silencing of DcR1 (zeige TNFRSF10C Proteine) and DcR2 (zeige CCR6 Proteine) is related to melanomagenesis.
transcript levels of UCHL1 (zeige UCHL1 Proteine), COL1A2 (zeige COL1A2 Proteine), THBS1 (zeige THBS1 Proteine) and TNFRSF10D were inversely correlated with promoter methylation
TRAIL receptor-4 expression profiles on T cells might be important in revelation of rheumatoid arthritis pathogenesis.
ANT2 (zeige SLC25A5 Proteine) shRNA treatment sensitized MCF7, T47 D, and BT474 cells to TRAIL-induced apoptosis by up-regulating the expression of TRAIL death receptors 4 and 5 (DR4 (zeige HLADRB4 Proteine) and DR5 (zeige TNFRSF10B Proteine)) and down-regulating the TRAIL decoy receptor 2 (DcR2).
these results demonstrated that hypoxia-inducible factor 1alpha played a crucial role in regulating the transcription of DcR2 (zeige CCR6 Proteine).
TNF-related apoptosis-inducing ligand (TRAIL (zeige TNFSF10 Proteine)) is not constitutively expressed in the human brain, whereas both apoptosis-mediating and apoptosis-blocking TRAIL receptors are found on neurons, astrocytes, and oligodendrocytes
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
, TNF receptor-related receptor for TRAIL
, TNF-related apoptosis-inducing ligand receptor 4
, TRAIL receptor 4
, TRAIL receptor with a truncated death domain
, decoy receptor 2
, tumor necrosis factor receptor superfamily member 10D