anti-Maus SET Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended SET Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
SET Nuclear Oncogene (SET) Antikörper
  • 2PP2A
  • I2PP2A
  • IGAAD
  • IPP2A2
  • PHAPII
  • TAF-I
  • TAF-IBETA
  • 2610030F17Rik
  • 5730420M11Rik
  • AA407739
  • I-2PP2A
  • StF-IT-1
  • SET translocation
  • SET nuclear oncogene
  • LOC403555
  • SET
  • Set
Epitop
AA 135-151, AA 66-81
2
Reaktivität
Human, Maus, Ratte (Rattus)
9
2
1
Wirt
Kaninchen
7
2
Klonalität
Polyklonal
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
6
2
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN372437
$ 500.50
Zzgl. Versandkosten $45.00

General

Antigen SET Nuclear Oncogene (SET) Antikörper
Epitop AA 135-151, AA 66-81
(2)
Reaktivität Human, Maus, Ratte (Rattus)
(9), (2), (1)
Wirt Kaninchen
(7), (2)
Klonalität
Polyklonal
Applikation Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(6), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-SET Antikörper

Target Details SET Anwendungsinformationen Handhabung Bilder
Spezifität This antibody recognizes SET/I2PP2A.
Kreuzreaktivität (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Reinigung Protein G Chromatography.
Immunogen A mixture of synthetic peptides corresponding to amino acids 66-81 and 135-151 of Human INHAT-1.
Isotyp IgG

Target Details SET

Produktdetails anti-SET Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung SET / I2PP2A (SET Antibody Abstract)
Hintergrund SET belongs to a family of multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. There are two named isoforms produced by alternative splicing: Isoform 1 and Isoform 2. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. A chromosomal aberration involving SET is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6,9)(q21,q34.1) with NUP214/CAN.Synonyms: I-2PP2A, IGAAD, Inhibitor of granzyme A-activated DNase, PHAPII, Phosphatase 2A inhibitor I2PP2A, TAF-I, Template-activating factor I
Gen-ID 6418
NCBI Accession NP_001116293
UniProt H0UI37
Pathways Apoptose

Anwendungsinformationen

Produktdetails anti-SET Antikörper Target Details SET Handhabung Bilder zurück nach oben
Applikationshinweise Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western blot: 1-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-SET Antikörper Target Details SET Anwendungsinformationen Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer PBS containing 0.1 mg/mL BSA as stabilizer and 0.02 % Sodium Azide as preservative.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Bilder

Produktdetails anti-SET Antikörper Target Details SET Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
 image for anti-SET Nuclear Oncogene (SET) (AA 135-151), (AA 66-81) antibody (ABIN372437) anti-SET Nuclear Oncogene (SET) (AA 135-151), (AA 66-81) antibody