PARP1 Proteine (PARP1)

Bezeichnung:
Poly (ADP-Ribose) Polymerase 1 Proteine (PARP1)
Auf www.antikoerper-online.de finden Sie aktuell 31 Poly (ADP-Ribose) Polymerase 1 (PARP1) Proteine von 14 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PARP1 Antikörper (424) und PARP1 Kits (39) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 522 PARP1 Produkte verfügbar.
Synonyme:
5830444G22Rik, Adprp, Adprt, ADPRT 1, Adprt1, AI893648, ARTD1, BEST:LD21673, C80510, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, dPARP, LD21673.3prime, padprt-1, parp, parp-1, PARP1, ppol, sPARP-1
alle Proteine anzeigen Gen GeneID UniProt
PARP1 142 P09874
Ratte PARP1 PARP1 25591 P27008
PARP1 11545  

Weitere Synonyme anzeigen

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Am meisten referenzierte PARP1 Proteine

  1. Human PARP1 Protein expressed in Baculovirus - ABIN1741730 : Woodhouse, Dianov: Poly ADP-ribose polymerase-1: an international molecule of mystery. in DNA repair 2008 (PubMed)
    Zeige alle 11 Referenzen für 1741730

  2. Human PARP1 Protein expressed in Baculovirus - ABIN1741729 : Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988 (PubMed)
    Zeige alle 9 Referenzen für 1741729

  3. Mouse (Murine) PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2008275 : Ariumi, Masutani, Copeland, Mimori, Sugimura, Shimotohno, Ueda, Hatanaka, Noda: Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. in Oncogene 1999 (PubMed)
    Zeige alle 3 Referenzen für 2008275

  4. Human PARP1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003759 : Ahel, Ahel, Matsusaka, Clark, Pines, Boulton, West: Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. in Nature 2008 (PubMed)
    Zeige alle 3 Referenzen für 2003759

  5. Human PARP1 Protein expressed in Escherichia coli (E. coli) - ABIN666940 : Li, Oh, Lau: The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. in Molecular and cellular endocrinology 2006 (PubMed)
    Zeige alle 2 Referenzen für 666940

Weitere Proteine zu PARP1 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Poly (ADP-Ribose) Polymerase 1 (PARP1) Interaktionspartner

  1. The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.

  2. A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (zeige PARK2 Proteine) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (zeige PARK2 Proteine) mutants.

  3. chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (zeige H2AFV Proteine) in a nucleosome positioned in promoter regions of PARP-1-dependent genes

  4. Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis

  5. PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.

  6. Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.

  7. PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).

  8. demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.

  9. PARP-e autoregulates Parp transcription

  10. propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff

Human Poly (ADP-Ribose) Polymerase 1 (PARP1) Interaktionspartner

  1. The NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma cells, and NF90 is a potential target to inhibit PARP1 activity.

  2. In response to UV irradiation, DICER (zeige DICER1 Proteine) is recruited to chromatin in a ZRF1 (zeige DNAJC2 Proteine)-mediated manner. The H2A-ubiquitin binding protein ZRF1 (zeige DNAJC2 Proteine) and DICER (zeige DICER1 Proteine) together impact on the chromatin conformation via PARP1.

  3. This paper summarises the most significant current literature on the involvement of PARP-1 in gastrointestinal cancer, focusing in particular on its role in the development and occurrence of tumours, providing information about clinical trials and exploring therapeutic possibilities. [review]

  4. PARP-1 stabilizes Sox2 (zeige SOX2 Proteine) binding to nucleosomes at suboptimal sites through cooperative interactions on DNA to regulate Sox2 (zeige SOX2 Proteine) pioneer activity at intractable genomic loci.

  5. PARP1 can modulate the tumor-suppressing function of HIPK2 (zeige HIPK2 Proteine) by regulating the protein stability of HIPK2 (zeige HIPK2 Proteine).

  6. HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 and/or Sirt6 (zeige SIRT6 Proteine)..physical interaction of HBx and PARP1 accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis

  7. these findings provide a foundation for the potential use of PARP1 inhibitors as a new treatment option for lung adenocarcinoma patients with elevated PARP1 expression.

  8. Elevated PARP expression correlated with worse prognosis in early stage breast cancer. [meta-analysis]

  9. study demonstrates that the individual and combined expression patterns of the DDR (zeige DDR1 Proteine) molecules PARP1, gammaH2AX (zeige H2AFX Proteine), BRCA1, and BRCA2 (zeige BRCA2 Proteine) could be predictive of the prognosis of STS (zeige STS Proteine) patients and suggests that controlling the activity of these DDR (zeige DDR1 Proteine) molecules could be employed in new therapeutic stratagems for the treatment of STS (zeige STS Proteine)

  10. PARP1/2 inhibitor simmiparib causes growth inhibition in cancer cell- or tissue-derived xenografts in nude mice.

Cow (Bovine) Poly (ADP-Ribose) Polymerase 1 (PARP1) Interaktionspartner

  1. no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected

  2. ADPRT Val762Ala and APE1 (zeige APEX1 Proteine) Asp148Glu polymorphisms are not associated with increased breast cancer risk

  3. analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites

  4. FGF2 (zeige FGF2 Proteine) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (zeige MAPK1 Proteine))-dependent pathway

Mouse (Murine) Poly (ADP-Ribose) Polymerase 1 (PARP1) Interaktionspartner

  1. The findings suggest that PARP1 inhibition protects against long-term ethanol-induced liver injury, as indicated by limited hepatocytes steatosis, apoptosis, inflammation levels, and neutrophil infiltration, mainly by limiting KC activation during the initiation of ALD.

  2. PARP-1 knockout resulted in lowered arginase II (zeige ARG2 Proteine) expression in macrophages and aortic endothelial cells.

  3. PARP-1 stabilizes Sox2 (zeige SOX2 Proteine) binding to nucleosomes at suboptimal sites through cooperative interactions on DNA to regulate Sox2 (zeige SOX2 Proteine) pioneer activity at intractable genomic loci.

  4. Delayed healing in ischemic and diabetic wounds is caused by PARP hyperactivity, and PARP inhibition significantly enhanced ischemic and diabetic wound healing by promoting angiogenesis.

  5. The findings highlight specific non-overlapping functions of PARP1 and PARP2 (zeige PARP2 Proteine) at H2AX (zeige H2AFX Proteine)-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 in nonhomologous end-joining-deficient cells.

  6. data establish the importance of XRCC1 (zeige XRCC1 Proteine) protein complexes for normal neurological function and identify PARP1 as a therapeutic target in DNA strand break repair-defective disease

  7. this study shows that PARP-1 inhibition plays role in puerarin-mediated protection from liver fibrosis

  8. might be involved in streptomycin ototoxicity by regulating AIF (zeige AIFM1 Proteine) translocation in cochlear hair cells

  9. Nonionizing radiofrequency exposure is capable of inducing PARP-1.

  10. our data suggest that Parp1 is involved in the plastic remodeling of chromatin structure after NT by supporting DNA repair and specific histone code modifications.

PARP1 Protein Überblick

Protein Überblick

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Alternative names and synonyms associated with PARP1

  • Poly-(ADP-ribose) polymerase (Parp)
  • poly (ADP-ribose) polymerase 1 (PARP1)
  • poly (ADP-ribose) polymerase 1 (Parp1)
  • poly (ADP-ribose) polymerase 1 (parp1)
  • poly (ADP-ribose) polymerase family, member 1 (Parp1)
  • poly ADP-ribose polymerase (Parp)
  • 5830444G22Rik Protein
  • Adprp Protein
  • Adprt Protein
  • ADPRT 1 Protein
  • Adprt1 Protein
  • AI893648 Protein
  • ARTD1 Protein
  • BEST:LD21673 Protein
  • C80510 Protein
  • CG17685 Protein
  • CG17696 Protein
  • CG17718 Protein
  • CG40411 Protein
  • D.PARP Protein
  • Dm.pARTa Protein
  • Dmel\\CG40411 Protein
  • dPARP Protein
  • LD21673.3prime Protein
  • padprt-1 Protein
  • parp Protein
  • parp-1 Protein
  • PARP1 Protein
  • ppol Protein
  • sPARP-1 Protein

Bezeichner auf Proteinebene für PARP1

CG40411-PB , CG40411-PC , Parp-PB , Parp-PC , Poly(ADP ribose) polymerase 1 , Poly(ADP)-Ribose polymerase , Poly(ADP-)Ribose polymerase , Poly(ADP-ribose) polymerase , Poly(ADP-ribose) polymerase 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) , ADP-ribosyltransferase NAD(+) , ADP-ribosyltransferase diphtheria toxin-like 1 , NAD(+) ADP-ribosyltransferase 1 , poly (ADP-ribose) polymerase family, member 1 , poly [ADP-ribose] polymerase 1 , poly(ADP-ribose) polymerase , poly(ADP-ribose) synthetase , poly(ADP-ribosyl)transferase , poly[ADP-ribose] synthase 1 , ADP-ribosyltransferase (NAD+ , ADP-ribosyltransferase 1 , ADPRT 1 , poly (ADP-ribose) polymerase) , poly(ADP-ribose) polymerase PARP-1 , poly[ADP-ribose] synthetase 1 , ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase) , PARP-1 , ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1 , ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1 , msPARP , Poly[ADP-ribose] synthase 1

GENE ID SPEZIES
3355109 Drosophila melanogaster
142 Homo sapiens
25591 Rattus norvegicus
286764 Bos taurus
397928 Xenopus laevis
396199 Gallus gallus
490385 Canis lupus familiaris
11545 Mus musculus
100689463 Cricetulus griseus
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