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Human PARP1 Protein expressed in Baculovirus - ABIN1741729
Lamarre, Talbot, de Murcia, Laplante, Leduc, Mazen, Poirier: Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. in Biochimica et biophysica acta 1988
Show all 9 Pubmed References
Human PARP1 Protein expressed in Baculovirus - ABIN1741730
Woodhouse, Dianov: Poly ADP-ribose polymerase-1: an international molecule of mystery. in DNA repair 2008
Show all 11 Pubmed References
The results demonstrate that PARylation process in Drosophila is tightly regulated in the context of strands-breaks repair; PARP is essential during the maintenance of DNA integrity, but dispensable in the DNA repair process.
A mutation of Parp also increases NAD+ levels; although, this was only observed in parkin (zeige PARK2 Proteine) mutant flies and not in the heterozygous Parp mutants, possibly owing to an increased PARP activity in the parkin (zeige PARK2 Proteine) mutants.
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (zeige H2AFV Proteine) in a nucleosome positioned in promoter regions of PARP-1-dependent genes
Based on these findings, we propose a model that explains how PARP1 activity impacts nucleolar functions and, consequently, ribosomal biogenesis
PARP is associated with the 5' end of Hsp70, and its enzymatic activity is rapidly induced by heat shock leading to nucleosome loss.
Activation of PARP-1 overexpression in the imago results in extension of the lifespan in females and males. The lifespan increase in females with PARP-1 conditional overexpression was accompanied by decrease of fertility.
PARP1 is targeted to chromatin by association with the histone H2A variant (H2Av).
demonstrate that this alteration specifically excludes PARP1 protein from heterochromatin and makes PARP1 unable to maintain repression of retrotransposable elements.
PARP-e autoregulates Parp transcription
propose that chromosomal PARP molecules become activated by developmental or environmental cues and strip nearby chromatin proteins off DNA to generate a puff
PARP1 recruits KLF4 (zeige KLF4 Proteine) to activate telomerase expression and stem cell pluripotency, indicating a positive regulatory role of the PARP1-KLF4 (zeige KLF4 Proteine) complex in telomerase expression in cancer and stem cells.
The results suggest that ATRX (zeige ATRX Proteine) is required to limit replication stress during cellular proliferation, whereas upregulation of PARP-1 activity functions as a compensatory mechanism to protect stalled forks, limiting genomic damage, and facilitating late-born neuron production.
Epithelial-mesenchymal-transition integrated with mesenchymal PARP-1 expression, predicts prostate cancer radioresistance.
this work indicates that suppression of JNK1 (zeige MAPK8 Proteine)/2 activity by MKP-1 (zeige DUSP1 Proteine) maintains PARP-1 levels and suggests that MKP-1 (zeige DUSP1 Proteine)-mediated cisplatin resistance can be bypassed by PARP-1 inhibition.
we report that AIF (zeige AIFM1 Proteine)-independent PARP-1-dependent necrosis constitutes a major mechanism of RPE (zeige RPE Proteine) cell death leading to retinal degeneration in dry age-related macular degeneration .
Data show that poly(ADP-ribose) polymerase 1 (PARP1)-mediated senescence rescue was accompanied by transcriptional activation of the melanocyte-lineage survival oncogene (zeige RAB1A Proteine) MITF (zeige MITF Proteine), indicating a role for PARP1 in melanomagenesis.
PARP1 is activated in the non-alcoholic fatty liver of mice and patients.
This study reports the novel findings that HER2 (zeige ERBB2 Proteine) increases PARP1 protein via suppression of the let-7a miRNA, which regulates the PARP1 3'-UTR. Moreover, HER2 (zeige ERBB2 Proteine) status correlates with high PARP1 and low let-7a in breast cancer clinical specimens.
Results show that PARP1 mediates 14-3-3s regulation of non-homologous end joining repair.
Identification of PARP-1 as a unique regulator of Il12b (zeige IL12B Proteine) transcription in response to inflammatory insults in an allele-differentiating manner
no difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected
ADPRT Val762Ala and APE1 (zeige APEX1 Proteine) Asp148Glu polymorphisms are not associated with increased breast cancer risk
analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites
FGF2 (zeige FGF2 Proteine) stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK (zeige MAPK1 Proteine))-dependent pathway
Data show that Tp53 (zeige TP53 Proteine)- and Atm (zeige ATM Proteine)-defective Chronic lymphocytic leukemia (CLL) mimicking the high-risk form of human disease and that Atm (zeige ATM Proteine)-deficient CLL is sensitive to PARP1 inhibition.
No increase of axonal regeneration was observed in Parp1(-/-) mice after optic nerve crush injury or dorsal hemisection of the thoracic spinal cord, and there was no improvement in motor function recovery. Comprehensive in vivo analysis reveals no indication that clinical PARP inhibitors will on their own provide benefit for recovery from central nervous system trauma.
MEIS2 (zeige MEIS2 Proteine) associates with chromatin-bound PBX1 (zeige PBX1 Proteine), recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber.
Activation of either PARP-1 or -2 is likely to play a role in muscle protein catabolism via oxidative stress, NF-kappaB (zeige NFKB1 Proteine) signaling, and enhanced proteasomal degradation in cancer-induced cachexia.
PARP-1 attenuates adipogenesis by PARylating C/EBPb (zeige CEBPB Proteine), a pro-adipogenic transcription factor, on three residues in its regulatory domain.
The findings suggest that PARP1 inhibition protects against long-term ethanol-induced liver injury, as indicated by limited hepatocytes steatosis, apoptosis, inflammation levels, and neutrophil infiltration, mainly by limiting KC activation during the initiation of ALD.
PARP-1 knockout resulted in lowered arginase II (zeige ARG2 Proteine) expression in macrophages and aortic endothelial cells.
PARP-1 stabilizes Sox2 (zeige SOX2 Proteine) binding to nucleosomes at suboptimal sites through cooperative interactions on DNA to regulate Sox2 (zeige SOX2 Proteine) pioneer activity at intractable genomic loci.
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
, ADP-ribosyltransferase NAD(+)
, ADP-ribosyltransferase diphtheria toxin-like 1
, NAD(+) ADP-ribosyltransferase 1
, poly (ADP-ribose) polymerase family, member 1
, poly [ADP-ribose] polymerase 1
, poly(ADP-ribose) polymerase
, poly(ADP-ribose) synthetase
, poly[ADP-ribose] synthase 1
, ADP-ribosyltransferase (NAD+
, ADP-ribosyltransferase 1
, ADPRT 1
, poly (ADP-ribose) polymerase)
, poly(ADP-ribose) polymerase PARP-1
, poly[ADP-ribose] synthetase 1
, ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
, ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 1
, Poly(ADP ribose) polymerase 1
, Poly(ADP)-Ribose polymerase
, Poly(ADP-)Ribose polymerase
, Poly(ADP-ribose) polymerase
, Poly(ADP-ribose) polymerase 1
, ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase)
, Poly[ADP-ribose] synthase 1
, LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1