anti-Human PARP1 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended PARP1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Poly (ADP-Ribose) Polymerase 1 (PARP1) Antikörper
  • BEST:LD21673
  • CG17685
  • CG17696
  • CG17718
  • CG40411
  • D.PARP
  • Dm.pARTa
  • Dmel\\CG40411
  • LD21673.3prime
  • PARP
  • PARP-1
  • PARP1
  • dPARP
  • parp
  • ADPRT
  • ADPRT 1
  • ADPRT1
  • ARTD1
  • PPOL
  • pADPRT-1
  • Adprt
  • Parp-1
  • adprt1
  • padprt-1
  • ppol
  • 5830444G22Rik
  • AI893648
  • Adprp
  • Adprt1
  • C80510
  • parp-1
  • sPARP-1
  • Poly-(ADP-ribose) polymerase
  • poly (ADP-ribose) polymerase 1
  • poly (ADP-ribose) polymerase family, member 1
  • poly ADP-ribose polymerase
  • Parp
  • PARP1
  • Parp1
  • parp1
Epitop
AA 200-230
58
19
19
19
19
19
19
19
18
18
18
17
15
14
12
9
8
8
8
6
5
5
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Ratte (Rattus)
387
84
79
18
17
13
9
9
7
6
5
3
2
2
1
1
1
1
1
Wirt
Kaninchen
377
48
1
Klonalität
Polyklonal
Konjugat
Dieser PARP1 Antikörper ist unkonjugiert
25
24
24
24
24
23
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
237
233
164
50
45
41
31
23
13
12
6
4
4
4
2
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN677903
$ 307.45
Zzgl. Versandkosten $45.00

General

Antigen Poly (ADP-Ribose) Polymerase 1 (PARP1) Antikörper
Epitop AA 200-230
(58), (19), (19), (19), (19), (19), (19), (19), (18), (18), (18), (17), (15), (14), (12), (9), (8), (8), (8), (6), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Ratte (Rattus)
(387), (84), (79), (18), (17), (13), (9), (9), (7), (6), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(377), (48), (1)
Klonalität
Polyklonal
Konjugat Dieser PARP1 Antikörper ist unkonjugiert
(25), (24), (24), (24), (24), (23)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(237), (233), (164), (50), (45), (41), (31), (23), (13), (12), (6), (4), (4), (4), (2), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PARP1 Antikörper

Target Details PARP1 Anwendungsinformationen Handhabung Referenzen für anti-PARP1 Antikörper (ABIN677903) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human PARP1
Isotyp IgG

Target Details PARP1

Produktdetails anti-PARP1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-PARP1 Antikörper (ABIN677903) Bilder zurück nach oben
Antigen
Andere Bezeichnung Parp1 (PARP1 Antibody Abstract)
Hintergrund

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

Subcellular location: Nucleus

Synonyms: PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1, Poly [ADP-ribose] polymerase 1, ADP-ribosyltransferase diphtheria toxin-like 1, NAD(+) ADP-ribosyltransferase 1, Poly[ADP-ribose] synthase 1, PARP1

Gen-ID 142
UniProt P09874
Pathways Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location

Anwendungsinformationen

Produktdetails anti-PARP1 Antikörper Target Details PARP1 Handhabung Referenzen für anti-PARP1 Antikörper (ABIN677903) Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PARP1 Antikörper Target Details PARP1 Anwendungsinformationen Referenzen für anti-PARP1 Antikörper (ABIN677903) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-PARP1 Antikörper (ABIN677903)

Produktdetails anti-PARP1 Antikörper Target Details PARP1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)).

Ma, Liu, Wang, Liu, Chen, Valle, Zuo, Xia, Liu: "Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals." in: ACS nano, Vol. 9, Issue 10, pp. 10498-515, 2015

Bilder

Produktdetails anti-PARP1 Antikörper Target Details PARP1 Anwendungsinformationen Handhabung Referenzen für anti-PARP1 Antikörper (ABIN677903) zurück nach oben
Bilder des Herstellers
Immunofluorescence (IF) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 200-230) antibody (ABIN677903) Formalin-fixed and paraffin embedded rat brain labeled with Anti PARP (N-Terminus) Po...
SDS-PAGE (SDS) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 200-230) antibody (ABIN677903) Lane 1: human colon carcinoma lysates Lane 2: rat brain lysates probed with Anti PARP...
Western Blotting (WB) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 200-230) antibody (ABIN677903) Human Raji lysates probed with Rabbit Anti-PARP1 Polyclonal Antibody, Unconjugated a...
Western Blotting (WB) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 200-230) antibody (ABIN677903) Human HeLa lysates probed with Rabbit Anti-PARP1 Polyclonal Antibody, Unconjugated a...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 200-230) antibody (ABIN677903) Paraformaldehyde-fixed, paraffin embedded mouse brain, Antigen retrieval by boiling i...