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Human Lamin A/C ELISA Kit für Sandwich ELISA - ABIN421168
Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
The loss of lamin-B (zeige LMNB1 ELISA Kits) leads to systemic inflammation and aging.
nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin
of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C
Rab5 (zeige RAB5A ELISA Kits) associated in vivo with nuclear Lamin and mushroom body defect (Mud (zeige AP5M1 ELISA Kits)), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA (zeige NUMA1 ELISA Kits)).
Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina.
Lamin mutation is associated with neuromuscular defects and premature aging.
prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B (zeige LMNB1 ELISA Kits) envelope.
Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis.
The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila.
Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal
results have important implications for understanding the tissue-specific regulation and functions of the lamin A gene
The induction of embryonic senescence and laminopathies in zebrafish harboring disturbed expressions of the lamin A gene, is described.
our findings indicate that altered mTOR (zeige FRAP1 ELISA Kits) signaling in Lmna(-/-) mice leads to a lipodystrophic phenotype that can be rescued with rapamycin, highlighting the effect of loss of adipose tissue in Lmna(-/-) mice and the consequences of altered mTOR (zeige FRAP1 ELISA Kits) signaling
results suggest that lamin A plays important roles in maintaining the osteoblast differentiation and function
these findings show that cardiac ERK1/2 (zeige MAPK1/3 ELISA Kits) activity is modulated in part by TGF-b/Smad (zeige SMAD1 ELISA Kits) signaling, leading to altered activation of CTGF/CCN2 (zeige CTGF ELISA Kits) to mediate fibrosis and alter cardiac function. This identifies a novel mechanism in the development of LMNA cardiomyopathy.
Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals
SUMO1 (zeige SUMO1 ELISA Kits) conjugation of RB and Lamin A/C is modulated by the SUMO protease SENP1 (zeige SENP1 ELISA Kits) and that sumoylation of both proteins is required for their interaction.
Lmna-deficient cells show a compromised strain avoidance response, which is completely abolished when topographical cues and uniaxial strain are applied along the same direction.
While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 (zeige NUP160 ELISA Kits) localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin (zeige EMD ELISA Kits), also impact gene regulation and lineage differentiation in early embryos.
administration of the exon 11 ASO reduced lamin A expression in wild-type mice and progerin expression in an HGPS mouse model.
stabilization of perinuclear actin strengthens the transient interactions of lamin A with chromatin
we demonstrate that BAF (zeige BANF1 ELISA Kits) is necessary to modulate prelamin A effects on chromatin structure
Dysmorphic nuclei in patients with an LMNA mutation correlate with the age of heart disease presentation.
These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 (zeige GABPA ELISA Kits) response to arsenic and cadmium.
developed a proteomic analysis of plasma samples from a family showing history of dilated cardiomyopathy caused by a LMNA mutation, which may lead to premature death or cardiac transplant
Exome sequencing of the proband revealed an extremely rare missense heterozygous variant c.1711_1712CG>TC; p.(Arg571Ser) in LMNA which was confirmed by Sanger sequencing in both the patients. Interestingly, the mutation had no effect on mRNA splicing or relative expression of lamin A or C mRNA and protein in the lymphoblasts
Case Report: pathogenic LMNA mutation gives unifying diagnosis explaining arrhythmogenic right ventricular cardiomyopathy and Charcot-Marie-Tooth type 2B1 (zeige SPI1 ELISA Kits) phenotypes.
Standard Sanger sequencing of LMNA exon 11 DNA from blood-derived WBCs and cultured skin fibroblasts sequenced at passages 1, 3 and 8 detected differing progerin-producing mutations in the same nucleotide of the exon 11 intronic splice donor site (see online supplementary figure.
the CNOT1 (zeige CNOT1 ELISA Kits)-LMNA-Hedgehog (zeige SHH ELISA Kits) signaling pathway axis exerts an oncogenic role in osteosarcoma progression, which could be a potential target for gene therapy.
Pathogenic variants in the LMNA gene responsible for nearly 10%-15%% of Familial Dilated Cardiomyopathy cases.
low lamin A but not lamin C expression in pleural metastatic cells could represent a major actor in the development of metastasis, associated with epithelial to mesenchymal transition and could account for a pejorative factor correlated with a poor Performance status.
Both anti-lamin A/C and anti-lamin B (zeige LMNB1 ELISA Kits) staining were clearly present in all embryonic stages.
A study mapping the location of procine lamin type A to chromosome 4q is presented.
These results indicate that thyroid hormone (zeige PTH ELISA Kits)-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.
LIII filaments appear identical to the endogenous lamina, whereas lamin B2 (zeige LMNB2 ELISA Kits) assembles into filaments that are organized less precisely; Lamin A induces sheets of thicker filaments on the endogenous lamina and increases the rigidity of the nuclear envelope
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
, intermediate filament-like lamina
, lamin A
, lamin B
, lamin D
, lamin D[]
, lamin D[[m]]0
, lamin D[[o]]
, lamin Dm0
, lamin Dm[]
, lamin Dmo
, nuclear lamin
, lamin B3
, lamin A/C
, lamin LIII
, lamin C
, 70 kDa lamin
, lamin A/C-like 1
, renal carcinoma antigen NY-REN-32
, lamin C2