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Differential proteomics were used to identify granzyme B substrates in three unrelated bacteria: Escherichia coli, Listeria monocytogenes, and Mycobacteria tuberculosis. Granzyme B cleaves a highly conserved set of proteins in all three bacteria, which function in vital biosynthetic and metabolic pathways that are critical for bacterial survival under diverse environmental conditions.
this study shows that gzmA (zeige GZMA Antikörper) and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae
Released granzyme B induces DNA fragmentation in intraepithelial lymphocytes independently of Perforin (zeige PRF1 Antikörper)
serglycin (zeige SRGN Antikörper) plays a critical role in the maturation of dense-core cytotoxic granules in cytotoxic lymphocytes and the trafficking and storage of perforin (zeige PRF1 Antikörper) and granzyme B, whereas granzyme A (zeige GZMA Antikörper) is unaffected
these results suggest a perforin (zeige PRF1 Antikörper)-independent, extracellular role for GzmB in the pathogenesis of cardiac fibrosis
data indicate an involvement of granzyme B in the neuroinflammation mediated by Eomes (zeige EOMES Antikörper)(+) CD4 (zeige CD4 Antikörper)(+) T cells.
Data suggest that targeting granzyme B (GzmB) in selected T cell subsets may provide a strategy to control graft-versus-host disease (GVHD).
These findings indicate a significant role for GzmB in extracellular matrix degradation that may have implications in many age-related chronic inflammatory diseases.
Different natural variants of granzyme B have a profound impact on the immune response to a common and authentic viral pathogen.
Visualization of granzyme B-expressing CD8 (zeige CD8A Antikörper) T cells during primary and secondary immune responses to Listeria monocytogenes.
Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 (zeige PADI4 Antikörper) epitopes in rheumatoid arthritis.
our results suggest granzyme B PET imaging can serve as a quantitatively useful predictive biomarker for efficacious responses to cancer immunotherapy.
Plasma GzmB levels may reflect the degree of pruritus and dermatitis in patients with atopic dermatitis
These results suggest the critical importance of miR (zeige MLXIP Antikörper)-378 in the regulation of GrzB expression and a protective role for GrzB in controlling dengue virus replication in vivo.
Analysis of infiltrating granzyme B-expressing T cells at the invasive borders of the colon tumors revealed a significant difference in expression granzyme by race underlining decreased antitumor cytotoxic immunity in African Americans.
Increased TIM3 (zeige HAVCR2 Antikörper)+CD8 (zeige CD8A Antikörper)+T cells with lower perforin (zeige PRF1 Antikörper) and granzyme B expression and higher CD95 (zeige FAS Antikörper) expression in MDS (zeige PAFAH1B1 Antikörper) patients were observed.
Carbamate pesticides significantly reduced the intracellular levels of perforin (zeige PRF1 Antikörper), GrA (zeige NR3C1 Antikörper), GrB, Gr3 (zeige PRLHR Antikörper)/K, and GRN (zeige GRN Antikörper) in NK-92CI cells.
granzyme-B levels were found to be significantly associated with increased insulin (zeige INS Antikörper) resistance in adolescent polycystic ovary syndrome patients. Additionally, elevated levels of serum granzyme-B were predictive for increased cardiovascular risk in PCOS patients
results suggest that enhanced IL-21R (zeige IL21R Antikörper) expression of CD19 (zeige CD19 Antikörper)(+)CD5 (zeige CD5 Antikörper)(+) B cells and production of IL-21 (zeige IL17C Antikörper) by iNKT cells may play an important role in the pathogenesis of pSS (zeige CDSN Antikörper) by regulating CD19 (zeige CD19 Antikörper)(+)CD5 (zeige CD5 Antikörper)(+) B cell functions and increasing GrB production, presumably leading to a counter-regulatory effect in the disease.
It is a cytotoxic genes in the endometrium and hightly expressed in the peri (zeige PLIN1 Antikörper)-implantation endometrium.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
, cytotoxic cell protease 1
, granzyme B(G,H)
, T-cell serine protease 1-3E
, cathepsin G-like 1
, cytotoxic T-lymphocyte proteinase 2
, cytotoxic serine protease B
, fragmentin 2
, human lymphocyte protein
, GLP I
, GLP III
, granzyme-like protein 1
, granzyme-like protein I
, natural killer cell protease 1
, granzyme H
, duodenase I
, duodenum serine protease