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Human CYLD Protein expressed in HEK-293 Cells - ABIN2712747
Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. in PLoS ONE 2014
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (zeige DNMT1 Proteine)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (zeige DNMT1 Proteine)-linked chains are presented.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (zeige MYD88 Proteine)-mediated signaling by directly interacting with MyD88 (zeige MYD88 Proteine) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (zeige MYD88 Proteine) at lysine 231.
CYLD interrupts the ERK (zeige EPHB2 Proteine)- and p38 (zeige CRK Proteine)-/AP-1 (zeige JUN Proteine) and c-Myc (zeige MYC Proteine) pathways to suppress Nrf2 (zeige NFE2L2 Proteine)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Data show that the in utero death of NF-NF (zeige NFASC Proteine)-kappaB (zeige NFKB1 Proteine) essential modulator (NEMO (zeige IKBKG Proteine)) and cylindromatosis protein double mutant mice is mediated by TNF (zeige TNF Proteine) receptor 1 (TNFR1 (zeige TNFRSF1A Proteine)) signaling and can be rescued by TNFR1 (zeige TNFRSF1A Proteine) deficiency.
CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (zeige NFKB1 Proteine) dependent anti-apoptotic signaling.
In contrast to full-length CYLD, the immune function of short splice variant CYLD (sCYLD) is insufficiently described. To explore sCYLD's function in infection, investigated whether dendritic cell-specific sCYLD regulates the pathogenesis of listeriosis.
The ciliary function of CYLD is partially attributed to its deconjugation of the polyubiquitin (zeige UBB Proteine) chain from centrosomal protein of 70 kDa (Cep70 (zeige CEP70 Proteine)), a requirement for Cep70 (zeige CEP70 Proteine) to interact with gamma-tubulin (zeige TUBG1 Proteine) and localize at the centrosome.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (zeige STAT3 Proteine) and miR (zeige MLXIP Proteine)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
CYLD Promotes TNF-alpha (zeige TNF Proteine)-Induced Cell Necrosis Mediated by RIP-1 (zeige UQCRFS1 Proteine) in Human Lung Cancer Cells
Low CYLD expression is associated with hepatocellular carcinoma.
miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (zeige NFKB1 Proteine) pathway and the downstream targets, livin (zeige BIRC7 Proteine) and survivin (zeige BIRC5 Proteine), which potentially induced GC chemoresistance.
Data show that cylindromatosis (CYLD) overexpression and livin (zeige BIRC7 Proteine) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (zeige BLNK Proteine)) cells.
aberrantly expressed miR (zeige MLXIP Proteine)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer
These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.
Novel CYLD germline mutations c.1821_1826+1delinsCT/L607Ffs*9, c.2666A>T/p.D889V and c.2712delT/p.905Kfs*8 were identified in unrelated Brooke-Spiegler Syndrome patients.
Study founds the levels of CYLD and SMAD7 (zeige SMAD7 Proteine) significantly decreased in oral squamous cell carcinoma (OSSC) cells and proposes a model that CYLD suppresses OSCC metastases through SMAD7 (zeige SMAD7 Proteine). Downregulation of CYLD appears to directly contribute to the distal metastases of primary OSCC and subsequently poor prognosis.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, ubiquitin carboxyl-terminal hydrolase CYLD
, deubiquitinating enzyme CYLD
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, retinitis pigmentosa 1 homolog
, ubiquitin specific peptidase like 2