CYLD Proteine (CYLD)

Cylindromatosis (Turban Tumor Syndrome) Proteine (CYLD)
Auf finden Sie aktuell 8 Cylindromatosis (Turban Tumor Syndrome) (CYLD) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CYLD Antikörper (79) und CYLD Kits (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 99 CYLD Produkte verfügbar.
2010013M14Rik, 2900009M21Rik, BRSS, C130039D01Rik, CDMT, cyld, CYLD1, CYLDI, EAC, LRRGT00003, MFT, MFT1, mKIAA0849, Rp1, Rp1h, SBS, TEM, USPL2
alle Proteine anzeigen Gen GeneID UniProt
Ratte CYLD CYLD 100362727  
CYLD 74256 Q80TQ2
CYLD 1540 Q9NQC7

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Am meisten referenzierte CYLD Proteine

  1. Human CYLD Protein expressed in HEK-293 Cells - ABIN2712747 : Thein, Tao-Cheng, Li, Bayer, Reese, Dosemeci: CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. in PLoS ONE 2014 (PubMed)

Weitere Proteine zu CYLD Interaktionspartnern

Zebrafish Cylindromatosis (Turban Tumor Syndrome) (CYLD) Interaktionspartner

  1. The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (zeige DNMT1 Proteine)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (zeige DNMT1 Proteine)-linked chains are presented.

Mouse (Murine) Cylindromatosis (Turban Tumor Syndrome) (CYLD) Interaktionspartner

  1. TLR4 (zeige TLR4 Proteine) activates CASPASE-8 (zeige CASP8 Proteine) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (zeige RNF138 Proteine)- and RIPK1 (zeige RIPK1 Proteine)-dependent manner to disable necroptosis in macrophages.

  2. CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (zeige NOX4 Proteine) and may play a role in vascular remodeling.

  3. this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease

  4. Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis

  5. Deubiquitinase CYLD negatively regulates MyD88 (zeige MYD88 Proteine)-mediated signaling by directly interacting with MyD88 (zeige MYD88 Proteine) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (zeige MYD88 Proteine) at lysine 231.

  6. CYLD interrupts the ERK (zeige EPHB2 Proteine)- and p38 (zeige CRK Proteine)-/AP-1 (zeige JUN Proteine) and c-Myc (zeige MYC Proteine) pathways to suppress Nrf2 (zeige NFE2L2 Proteine)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.

  7. Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.

  8. The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.

  9. Data show that the in utero death of NF-NF (zeige NFASC Proteine)-kappaB (zeige NFKB1 Proteine) essential modulator (NEMO (zeige IKBKG Proteine)) and cylindromatosis protein double mutant mice is mediated by TNF (zeige TNF Proteine) receptor 1 (TNFR1 (zeige TNFRSF1A Proteine)) signaling and can be rescued by TNFR1 (zeige TNFRSF1A Proteine) deficiency.

  10. CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (zeige NFKB1 Proteine) dependent anti-apoptotic signaling.

Human Cylindromatosis (Turban Tumor Syndrome) (CYLD) Interaktionspartner

  1. The data reveal SPATA2 (zeige SPATA2 Proteine) as a high-affinity binding partner of CYLD and HOIP (zeige RNF31 Proteine), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (zeige NFKB1 Proteine) signaling.

  2. The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (zeige TRAF3 Proteine) (tumor necrosis factor (zeige TNF Proteine) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (zeige TRAF3 Proteine) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.

  3. The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.

  4. STAT3 (zeige STAT3 Proteine) and miR (zeige MLXIP Proteine)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.

  5. CYLD Promotes TNF-alpha (zeige TNF Proteine)-Induced Cell Necrosis Mediated by RIP-1 (zeige UQCRFS1 Proteine) in Human Lung Cancer Cells

  6. Low CYLD expression is associated with hepatocellular carcinoma.

  7. miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (zeige NFKB1 Proteine) pathway and the downstream targets, livin (zeige BIRC7 Proteine) and survivin (zeige BIRC5 Proteine), which potentially induced GC chemoresistance.

  8. Data show that cylindromatosis (CYLD) overexpression and livin (zeige BIRC7 Proteine) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (zeige BLNK Proteine)) cells.

  9. aberrantly expressed miR (zeige MLXIP Proteine)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer

  10. These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.

CYLD Protein Überblick

Protein Überblick

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with CYLD

  • cylindromatosis (turban tumor syndrome) (CYLD)
  • cylindromatosis (turban tumor syndrome), a (cylda)
  • ubiquitin carboxyl-terminal hydrolase CYLD (LOC100362727)
  • cylindromatosis (turban tumor syndrome) (Cyld)
  • 2010013M14Rik Protein
  • 2900009M21Rik Protein
  • BRSS Protein
  • C130039D01Rik Protein
  • CDMT Protein
  • cyld Protein
  • CYLD1 Protein
  • CYLDI Protein
  • EAC Protein
  • LRRGT00003 Protein
  • MFT Protein
  • MFT1 Protein
  • mKIAA0849 Protein
  • Rp1 Protein
  • Rp1h Protein
  • SBS Protein
  • TEM Protein
  • USPL2 Protein

Bezeichner auf Proteinebene für CYLD

cylindromatosis (turban tumor syndrome) , probable ubiquitin carboxyl-terminal hydrolase CYLD-like , ubiquitin carboxyl-terminal hydrolase CYLD , deubiquitinating enzyme CYLD , ubiquitin thioesterase CYLD , ubiquitin thiolesterase CYLD , ubiquitin-specific-processing protease CYLD , probable ubiquitin carboxyl-terminal hydrolase CYLD , retinitis pigmentosa 1 homolog , ubiquitin specific peptidase like 2

100050308 Equus caballus
556823 Danio rerio
100467467 Ailuropoda melanoleuca
100547998 Meleagris gallopavo
100362727 Rattus norvegicus
74256 Mus musculus
312937 Rattus norvegicus
1540 Homo sapiens
611649 Canis lupus familiaris
536421 Bos taurus
415725 Gallus gallus
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