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theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (zeige EGFR ELISA Kits) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (zeige EGFR ELISA Kits) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (zeige NFKB1 ELISA Kits) signaling, miR (zeige MLXIP ELISA Kits)-130b can in return sustain the persistent activation of NF-kappaB (zeige NFKB1 ELISA Kits), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (zeige F2 ELISA Kits)-mediated MALT1 (zeige MALT1 ELISA Kits) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
MiR (zeige MLXIP ELISA Kits)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
SPATA2 has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (zeige RNF31 ELISA Kits) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
The data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP (zeige RNF31 ELISA Kits), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (zeige NFKB1 ELISA Kits) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (zeige TRAF3 ELISA Kits) (tumor necrosis factor (zeige TNF ELISA Kits) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (zeige TRAF3 ELISA Kits) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (zeige STAT3 ELISA Kits) and miR (zeige MLXIP ELISA Kits)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (zeige HDAC6 ELISA Kits) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
TLR4 (zeige TLR4 ELISA Kits) activates CASPASE-8 (zeige CASP8 ELISA Kits) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (zeige RNF138 ELISA Kits)- and RIPK1 (zeige RIPK1 ELISA Kits)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (zeige NOX4 ELISA Kits) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (zeige MYD88 ELISA Kits)-mediated signaling by directly interacting with MyD88 (zeige MYD88 ELISA Kits) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (zeige MYD88 ELISA Kits) at lysine 231.
CYLD interrupts the ERK (zeige EPHB2 ELISA Kits)- and p38 (zeige CRK ELISA Kits)-/AP-1 (zeige JUN ELISA Kits) and c-Myc (zeige MYC ELISA Kits) pathways to suppress Nrf2 (zeige NFE2L2 ELISA Kits)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (zeige DNMT1 ELISA Kits)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (zeige DNMT1 ELISA Kits)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog