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Bone marrow mesenchymal stromal cells induce the rapid differentiation of CD11b+ myeloid cells from bone marrow progenitors, and such an activity requires the expression of nitric oxide synthase-2.
Mac-1(-/-) pups have reduced numbers of type I alveolar cells, respiratory failure and low survival.
data provide evidence that the NLRC4 (zeige NLRC4 ELISA Kits) inflammasome contributes to resistance through regulation of caspase-1 (zeige CASP1 ELISA Kits), IL-1beta (zeige IL1B ELISA Kits) and IL-18 (zeige IL18 ELISA Kits) in a CD11blowLy6Glow population of cells
CD11b+Gr-1 (zeige GSR ELISA Kits)+ myeloid-derived suppressor cells suppress T cells in an IFN-gamma (zeige IFNG ELISA Kits)- and nitric oxide-dependent manner to reduce atherosclerotic lesion development in LDLr (zeige LDLR ELISA Kits) deficient mice.
Mesenteric lymph node CD11b(-) CD103 (zeige ITGAE ELISA Kits)(+) PD-L1 (zeige CD274 ELISA Kits)(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (zeige TGFB1 ELISA Kits) activation.
TLR-stimulated macrophages from CD11B SNP carriers showed increased basal expression of IFN regulatory factor 7 (IRF7 (zeige IRF7 ELISA Kits)) and IFN-beta (zeige IFNB1 ELISA Kits), as well as increased nuclear exclusion of FOXO3 (zeige FOXO3 ELISA Kits), which was suppressed by LA1-dependent activation of CD11b.
The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser (zeige SIGLEC1 ELISA Kits) in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta (zeige YWHAZ ELISA Kits) binding site that modulates integrin alphaM(PS)beta2 outside-in signaling
a novel role for CR3 and microglia in brain Abeta (zeige APP ELISA Kits) metabolism and defining a potential new therapeutic target in Alzheimer disease.
Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4 (zeige TIMD4 ELISA Kits)) on a proportion of CD103 (zeige ITGAE ELISA Kits)+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).
this study shows that genetic deletion of CD11b confers collagen-induced arthritis susceptibility through IL-6 (zeige IL6 ELISA Kits)-mediated Th17 differentiation in C57BL/6 mice, which are normally resistant to this disease
The use of CD33 (zeige CD33 ELISA Kits)(+)CD11b(+)HLA-DR(-) cells as a predictive and prognostic biomarker.
demonstrate for the first time a dependency of monocyte-platelet aggregates and CD11b expression on monocytes in the presence of atrial fibrillation (AF) and support the notion of a close relationship between AF, thrombogenesis and inflammation
Increased CD11b+ and CD200+ monocytes in those with a strong presence of BVN indicate that BVN development may be associated with retinal injury and a VEGF-mediated process that is either reflected or propelled by systemic changes in monocytes.
This study, we provide evidence supporting a crucial pathogenic role for alphaM-integrin (CD11b) in acute inflammatory demyelinating polyradiculoneuropathy mononuclear leukocyte trafficking.
FRbeta (zeige FOLR2 ELISA Kits) as a novel CD11b/CD18 regulator for trafficking and homing of a subset of macrophages on collagen.
this study shows that upregulation of CD11b after stimulation with IL-8 (zeige IL8 ELISA Kits) is more pronounced in adults than in neonates, whereas fMLP (zeige FPR1 ELISA Kits) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults
Ingestion of amino acid supplement did not influence CD11b expression.
This metaanalysis indicates that polymorphisms in the pathways of immune complex clearance, such as the FcgammaRIIIa, FcgammaRIIIb, and ITGAM genotypes, are potential susceptibility genes for neuropsychiatric systemic lupus erythematosus.
These data describe the presence of specific pattern recognition receptor transcripts in the mRNA isolated from bovine neutrophil and show a CD11b-/Ca(2 (zeige CA2 ELISA Kits)+) dependent ROS (zeige ROS1 ELISA Kits) production
The molecular cloning and characterization of CD11b from cattle and its similarities to other species are presented.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
MAC-1 alpha subunit
, integrin alpha M
, integrin alpha-M
, CD11 antigen-like family member B
, CD11B (p170)
, CR-3 alpha chain
, Mac-1 alpha
, cell surface glycoprotein MAC-1 alpha subunit
, cell surface glycoprotein MAC-1 subunit alpha
, complement component receptor 3 alpha-a
, complement receptor type 3
, leukocyte adhesion receptor MO1
, macrophage antigen alpha
, antigen CD11b (p170)
, macrophage antigen alpha polypeptide
, neutrophil adherence receptor alpha-M subunit
, leukocyte integrin alpha-M chain
, complement receptor 3
, leukocyte integrin alpha M