Caspase 8 Proteine (CASP8)

Auf www.antikoerper-online.de finden Sie aktuell 29 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Caspase 8 Antikörper (397) und Caspase 8 Kits (70) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 518 Caspase 8 Produkte verfügbar.
Synonyme:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
alle Proteine anzeigen Gen GeneID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

Caspase 8 Proteine (CASP8) nach Spezies

Weitere Proteine zu Caspase 8 Interaktionspartnern

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (zeige AMD1 Proteine)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (zeige TP53 Proteine)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Proteine) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Statistically significant increases in the expression of Fas (zeige FAS Proteine) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (zeige DAPK1 Proteine), Traf3 (zeige TRAF3 Proteine), Tnsf12, Tnfrsf1A (zeige TNFRSF1A Proteine) and Ripk1 (zeige RIPK1 Proteine).

  2. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (zeige RIPK3 Proteine))-mediated necroptosis.

  3. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

  4. Data indicate that NLRC4 (zeige NLRC4 Proteine) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (zeige IL18 Proteine) release, and implicate Caspase-8 in NLRC4 (zeige NLRC4 Proteine) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (zeige CASP1 Proteine) and Caspase-8.

  5. ING4 (zeige ING4 Proteine) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (zeige FAS Proteine)-induced apoptosis in a caspase-8-dependent pathway.

  6. studies have uncovered the combined actions of the NLRP3 (zeige NLRP3 Proteine) inflammasome and caspase 8 leading to IL-1beta (zeige IL1B Proteine) maturation and the directionality of IL-1beta (zeige IL1B Proteine) in driving disease inPstpip2(cmo (zeige PSTPIP2 Proteine))mice.

  7. Chronic TLR Stimulation Controls NLRP3 (zeige NLRP3 Proteine) Inflammasome Activation through IL-10 (zeige IL10 Proteine) Mediated Regulation of NLRP3 (zeige NLRP3 Proteine) Expression and Caspase-8 Activation

  8. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  9. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (zeige RIPK3 Proteine)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (zeige LYZ Proteine) M) Casp8fl/fl (caspase 8) mice.

  10. CASP8 deletion did not affect the overall number of microglia expressing the pan specific microglia marker, Iba1 (zeige AIF1 Proteine)

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Insertion genotype of CASP8 rs3834129 polymorphisms showed risk in CAD. CASP8 rs3769818 activates intronic cryptic donor.

  2. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase (zeige KARS Proteine) in exosomes from colorectal cancer cells.

  3. Fisetin inhibited Triple-Negative Breast Cancer Cells cell division and induced apoptosis, which was associated with mitochondrial membrane permeabilization and the activation of caspase-9 (zeige CASP9 Proteine) and caspase-8, as well as the cleavage of poly(ADP-ribose) polymerase-1 (zeige PARP1 Proteine).

  4. Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.

  5. Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD (zeige FADD Proteine) and caspase-8 and the distinct mechanisms of regulation by cFLIP (zeige CFLAR Proteine) and MC159 through comingling and capping, respectively.

  6. our novel findings expand our understanding of the key mechanisms underlying the anti-apoptotic functions of caspase-8 which may act as a critical block to existing antitumour therapies.

  7. Proteases caspase-1 (zeige CASP1 Proteine) and caspase-8 have redundant roles in cleaving IL-1beta (zeige IL1B Proteine) and promoting osteomyelitis. [review]

  8. Dasatinib, a c-Src (zeige SRC Proteine) inhibitor, dephosphorylated caspase-8 to facilitate necroptosis, rather than apoptosis, in paclitaxel-treated p-Casp8-expressing lung adenocarcinoma cells.

  9. Loss of function mutations in FAT1 and CASP8 prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.

  10. Dysregulation of a potassium channel (zeige KCNAB2 Proteine), THIK-1 (zeige KCNK13 Proteine), targeted by caspase-8, accelerates cell shrinkage.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (zeige CASP3 Proteine) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (zeige CASP9 Proteine).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (zeige STAT1 Proteine) at Ser (zeige SIGLEC1 Proteine)-727 and STAT1 (zeige STAT1 Proteine) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), IL-12p40, IL-1beta (zeige IL1B Proteine), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (zeige BCL2L1 Proteine).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) Interaktionspartner

  1. Induction of apoptosis through targeted activation of caspase (zeige CASP3 Proteine) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.

  2. Targeted gene knockdown of TNFRSF1B (zeige TNFRSF1B Proteine) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (zeige CASP2 Proteine) and P53 (zeige TP53 Proteine)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Proteine).

  3. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) Protein Überblick

Protein Überblick

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8)
  • death related ced-3/Nedd2-like protein (Dredd)
  • caspase 8, apoptosis-related cysteine peptidase (CASP8)
  • caspase-8 (AaeL_AAEL014148)
  • caspase-8 (casp8)
  • caspase 8 (LOC100222284)
  • caspase 8 (Casp8)
  • caspase 8 (LOC100348477)
  • ALPS2B Protein
  • CAP4 Protein
  • Casp-8 Protein
  • CASP8 Protein
  • casp8-A Protein
  • caspase-8 Protein
  • FLICE Protein
  • MACH Protein
  • MCH5 Protein
  • xCaspase-8 Protein
  • zgc:92075 Protein

Bezeichner auf Proteinebene für CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPEZIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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