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Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2487286
Appukuttan, Kasseckert, Micoogullari, Flacke, Kumar, Woste, Abdallah, Pott, Reusch, Ladilov: Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. in Cardiovascular research 2012
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Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688831
Nicholson, Ali, Thornberry, Vaillancourt, Ding, Gallant, Gareau, Griffin, Labelle, Lazebnik: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. in Nature 1995
Show all 3 Pubmed References
Human Caspase 8 Protein expressed in Escherichia coli (E. coli) - ABIN2688834
Patel, Gores, Kaufmann: The role of proteases during apoptosis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996
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Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (zeige AMD1 Proteine)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (zeige TP53 Proteine)-overexpressed apoptotic embryos.
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID Proteine) and Caspases-2 and -8
Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.
inhibition of TAK1 (zeige NR2C2 Proteine) triggered two caspase 8 activation pathways through the induction of RIP1 (zeige RALBP1 Proteine)-FADD (zeige FADD Proteine)-caspase 8 complex as well as FLIP cleavage/degradation.
this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation
Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 (zeige CASP3 Proteine) cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.
caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.
Statistically significant increases in the expression of Fas (zeige FAS Proteine) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (zeige DAPK1 Proteine), Traf3 (zeige TRAF3 Proteine), Tnsf12, Tnfrsf1A (zeige TNFRSF1A Proteine) and Ripk1 (zeige RIPK1 Proteine).
Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (zeige RIPK3 Proteine))-mediated necroptosis.
we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection
Data indicate that NLRC4 (zeige NLRC4 Proteine) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (zeige IL18 Proteine) release, and implicate Caspase-8 in NLRC4 (zeige NLRC4 Proteine) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (zeige CASP1 Proteine) and Caspase-8.
ING4 (zeige ING4 Proteine) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (zeige FAS Proteine)-induced apoptosis in a caspase-8-dependent pathway.
study shows genetic association of rare variants in CASP8 with Alzheimer's disease and proposes a mechanism of action mediated by decreased enzyme activity; for two CASP8 variants, p.K148R and p.I298V, the association remained significant in a large combined sample
Knockout (KO) or knockdown of caspase-8, CD95 (zeige FAS Proteine) or FADD (zeige FADD Proteine) prevents activation of Plk3 (zeige PLK3 Proteine) upon CD95 (zeige FAS Proteine) stimulation, suggesting a requirement of a functional death-inducing signaling complex for Plk3 (zeige PLK3 Proteine) activation.
CASP8: rs1045494 (C > T), PIK3R1: rs3756668 (A > G) and CASP7 (zeige CASP7 Proteine): rs4353229 (T > C), were associated with longer overall survival in limited disease-small cell lung cancer patients after chemoradiotherapy
SP-D (zeige SFTPD Proteine) increases the formation of nuclear and membrane blebs. Inhibition of caspase-8 confirms the effect of SP-D (zeige SFTPD Proteine) is unique to the caspase-8 pathway.
This is the first report, showing negative and independent prognostic impact of the CASP8 -652 6N Del and the 302His variant for breast cancer.
The C-terminal helical conformation of Bax (zeige BAX Proteine), not its primary sequence, appears to be critical for CASP8 recruitment and activation culminating in cell death.
Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (zeige IFNB1 Proteine) (TRIF (zeige TRIM69 Proteine)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (zeige TRIM69 Proteine)/RIPK1 (zeige RIPK1 Proteine)/caspase-8 occurs in fibrillary platforms.
S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (zeige CASP3 Proteine) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (zeige CASP9 Proteine).
Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (zeige STAT1 Proteine) at Ser (zeige SIGLEC1 Proteine)-727 and STAT1 (zeige STAT1 Proteine) binding to the caspase-8 promoter in cultured lung endothelial cells.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (zeige TNF Proteine), IL-6 (zeige IL6 Proteine), IL-12p40, IL-1beta (zeige IL1B Proteine), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (zeige BCL2L1 Proteine).
Induction of apoptosis through targeted activation of caspase (zeige CASP3 Proteine) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.
Targeted gene knockdown of TNFRSF1B (zeige TNFRSF1B Proteine) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (zeige CASP2 Proteine) and P53 (zeige TP53 Proteine)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (zeige CASP3 Proteine).
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
, xcaspase 8
, death related ced-3/Nedd2-like protein
, caspase 8, apoptosis-related cysteine peptidase
, caspase 8
, DEATH effector domain caspase
, Fas-linked ICE-like protease
, FADD-homologous ICE/CED-3-like protease
, FADD-like ICE
, ICE-like apoptotic protease 5
, MACH-alpha-1/2/3 protein
, MACH-beta-1/2/3/4 protein
, MORT1-associated ced-3 homolog
, apoptotic cysteine protease
, apoptotic protease Mch-5
, caspase 8, apoptosis-related cysteine protease
, cysteine protease