anti-Ratte (Rattus) Caspase 3 Antikörper für Enzyme Immunoassay

Recommended Caspase 3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) Antikörper
  • CC3
  • CG14902
  • Cas3
  • Casp 3
  • Casp3
  • Caspase-3
  • DECAY
  • Decay
  • Dmel\\CG14902
  • Drosophila executioner caspase related to Apopain/Yama
  • caspase 3
  • caspase-3
  • CG7788
  • DRICE
  • Dmel\\CG7788
  • DrICE
  • DrIce
  • Drice
  • ICE
  • crice
  • drICE
  • drIce
  • drice
  • ice
  • A830040C14Rik
  • AC-3
  • Apopain
  • CPP32
  • Lice
  • Yama
  • mldy
  • CPP32B
  • SCA-1
  • xcpp32
  • caspase 3, apoptosis-related cysteine peptidase
  • death executioner caspase related to Apopain/Yama
  • CG7788 gene product from transcript CG7788-RA
  • caspase 3
  • CASP3
  • decay
  • Ice
  • Casp3
  • casp3
Reaktivität
Human, Maus, Ratte (Rattus)
566
304
253
48
47
38
29
28
24
20
18
18
18
12
9
8
7
4
2
2
Wirt
Kaninchen
457
162
19
4
2
Klonalität
Polyklonal
Konjugat
Dieser Caspase 3 Antikörper ist unkonjugiert
27
24
19
14
9
9
9
6
4
4
4
4
4
4
4
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
482
238
219
146
95
78
55
51
44
29
28
13
9
9
6
5
4
3
2
2
2
2
2
2
2
1
1
1
1
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Bilder

Produktnummer ABIN498946
429,00 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN5555543 EIA WB Goat Internal Region Anmelden zum Anzeigen Polyclonal
1 ABIN2717099 EIA IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 1

anti-Caspase 3 Antikörper für Enzyme Immunoassay mit den meisten Publikationen

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Applikation / Reaktivität Ratte (Rattus)
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General

Antigen Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(566), (304), (253), (48), (47), (38), (29), (28), (24), (20), (18), (18), (18), (12), (9), (8), (7), (4), (2), (2)
Wirt Kaninchen
(457), (162), (19), (4), (2)
Klonalität
Polyklonal
Konjugat Dieser Caspase 3 Antikörper ist unkonjugiert
(27), (24), (19), (14), (9), (9), (9), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(482), (238), (219), (146), (95), (78), (55), (51), (44), (29), (28), (13), (9), (9), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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Produktdetails anti-Caspase 3 Antikörper

Target Details Caspase 3 Anwendungsinformationen Handhabung Bilder
Spezifität This antibody detects endogenous levels of Actived-Caspase-3 p17 protein.
Kreuzreaktivität (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Reinigung Affinity Chromatography using epitope-specific immunogen.

Target Details Caspase 3

Produktdetails anti-Caspase 3 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Caspase-3 (CASP3 Antibody Abstract)
Hintergrund Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.Synonyms: Apopain, CASP-3, CASP3, CPP-32, CPP32, Cysteine protease CPP32, SCA-1, SCA1, SREBP cleavage activity 1, Yama protein
Molekulargewicht approx. 17, 35 kDa
Gen-ID 836
NCBI Accession NP_004337
UniProt P42574
Forschungsgebiet Apoptosis/Necrosis, Autophagy
Pathways Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation

Anwendungsinformationen

Produktdetails anti-Caspase 3 Antikörper Target Details Caspase 3 Handhabung Bilder zurück nach oben
Applikationshinweise Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/20 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-Caspase 3 Antikörper Target Details Caspase 3 Anwendungsinformationen Bilder zurück nach oben
Konzentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Bilder

Produktdetails anti-Caspase 3 Antikörper Target Details Caspase 3 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 3 Antikörper (Caspase 3, Apoptosis-Related Cysteine Peptidase) (ABIN498946) Immunohistochemistry analyzes of Actived-Caspase-3 p17 Antibody in paraffin-em...
Western Blotting (WB) image for anti-Caspase 3 Antikörper (Caspase 3, Apoptosis-Related Cysteine Peptidase) (ABIN498946) Western blot analyzes of Actived-Caspase-3 p17 Antibody in extracts from sp20 ...