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Ark, Ozdemir, Polat: Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. in Apoptosis : an international journal on programmed cell death 2010
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Espín, Roca, Candel, Sepulcre, González-Rosa, Alcaraz-Pérez, Meseguer, Cayuela, Mercader, Mulero: TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. in Disease models & mechanisms 2013
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Sapet, Simoncini, Loriod, Puthier, Sampol, Nguyen, Dignat-George, Anfosso: Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. in Blood 2006
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caspase-2 has a role as an initiator caspase (zeige CASP3 ELISA Kits) in lipoapoptosis
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (zeige BID ELISA Kits) and Caspases-2 and -8
Caspase-2 phosphorylated at S135 binds 14-3-3zeta (zeige YWHAZ ELISA Kits), thus preventing C2 dephosphorylation.
The data demonstrate that cell death is prevented during mitosis through the inhibitory phosphorylation of caspase-2 and suggest that under conditions of mitotic arrest, cdk1 (zeige CDK1 ELISA Kits)-cyclin B1 (zeige CCNB1 ELISA Kits) activity must be overcome for apoptosis to occur.
Casp2(-/-) mice, which are more susceptible to genomic instability, are limited in their ability to respond to DNA damage and thus carry more damaged cells resulting in accelerated tumourigenesis.
BECN1/Beclin 1 (zeige BECN1 ELISA Kits) binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2-AMPK (zeige PRKAA1 ELISA Kits)-AKT (zeige AKT1 ELISA Kits)-MTOR (zeige FRAP1 ELISA Kits) and CASP2-AMPK (zeige PRKAA1 ELISA Kits)-MAPK (zeige MAPK1 ELISA Kits) by decreasing CASP2.
We further generated Casp2(C320S) mutant mice to demonstrate that caspase-2 catalytic activity is essential for its function in limiting aneuploidy. Our results provide direct evidence that the apoptotic activity of caspase-2 is necessary for deleting cells with mitotic aberrations to limit aneuploidy
These results provide the first evidence of caspase-2 in regulating haematopoietic stem cell and progenitor differentiation, as well as aneuploidy, in vivo.
Study describes a novel pathological process in which caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines.
Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease.
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein (zeige HOMER1 ELISA Kits) Raidd (zeige CRADD ELISA Kits)
Data show that indoles can effectively suppress acute hepatic inflammation caused by staphylococcal enterotoxin B (SEB) maybe mediated by decreased expression of miR-31 and caspase-2-dependent apoptosis in T cells.
Data indicate that the nucleotide-binding domain and leucine-rich repeat containing (zeige NLRX1 ELISA Kits) (NLRP3 (zeige NLRP3 ELISA Kits))-caspase-2 axis drives general endoplasmic reticulum (ER) stress-induced inflammasome activation.
these studies elucidate a Caspase-2-p53 (zeige TP53 ELISA Kits) signaling network that impacts lung tumorigenesis and chemotherapy response in vivo.
This peptide, Ac-VDTTD-AFC, was efficiently cleaved by purified caspase-2 and auto-activating caspase-2 in mammalian cells, and exhibited better selectivity for caspase-2 relative to caspase-3 (zeige CASP3 ELISA Kits) than reagents that are currently available.
There results support a special role for miR (zeige MLXIP ELISA Kits)-149 in malignant glioma by targeting Caspase-2
Whole exome sequencing (WES) of an affected fetus, and subsequent Sanger sequencing of the second fetus, revealed a homozygous frameshift variant in CRADD (zeige CRADD ELISA Kits), which encodes an adaptor protein that interacts with PIDD (zeige PIDD ELISA Kits) and caspase-2 to initiate apoptosis
This study shows that human procaspase-2 interaction with 14-3-3 zeta is governed by phosphorylation at both S139 and S164.
NPM1 (zeige NPM1 ELISA Kits)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade.
Sensitization of colon carcinoma cells to radiation-induced cell death and DNA-damage by HuR (zeige ELAVL1 ELISA Kits) knockdown critically depends on caspase-2.
BCL9L (zeige BCL9L ELISA Kits) dysfunction contributes to aneuploidy tolerance in both TP53 (zeige TP53 ELISA Kits)-WT and mutant cells by reducing basal caspase-2 levels and preventing cleavage of MDM2 (zeige MDM2 ELISA Kits) and BID (zeige BID ELISA Kits).
CASP2 down-regulation had a reverse relationship with miR (zeige MLXIP ELISA Kits)-383 down-regulation in regulating epithelial ovarian cancer development.
Results suggest that mutations at all three cleavage sites of caspase-2 protein neither affect the macromolecular core complex assembly, nor modify caspase-2 activity upon DNA damage. Consequently, caspase-2 activation occurs in the macromolecular complex without its dissociation.
These findings indicate that miR (zeige MLXIP ELISA Kits)-125a-5p decreases after HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
EtOH-induced mitochondria-mediated apoptosis is initiated by caspase-2 activation, which is regulated by CoQ10
the capacity for blastocysts to undergo further development is related to degree of group II caspase (zeige CASP3 ELISA Kits) activity
hypoxia/re-oxygenation injury in cultured proximal tubule cells induced apoptosis by activation of caspase-2, which is required for the mitochondrial translocation of Bax (zeige BAX ELISA Kits).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, ICH-1 protease
, protease ICH-1
, neural precursor cell expressed developmentally down-regulated protein 2
, protein phosphatase 1, regulatory subunit 57
, caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)
, ICH1 protease
, caspase 2, apoptosis-related cysteine protease
, cysteine protease caspase-2