ABL1 Proteine (ABL1)

Bezeichnung:
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase Proteine (ABL1)
Auf www.antikoerper-online.de finden Sie aktuell 26 C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ABL1 Antikörper (627) und ABL1 Kits (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 723 ABL1 Produkte verfügbar.
Synonyme:
Abl, ABL1, ABLL, AI325092, bcr/abl, c-Abl, CABL, cb272, E430008G22Rik, JTK7, MTP, p150, v-abl
alle Proteine anzeigen Gen GeneID UniProt
ABL1 25 P00519
ABL1 11350 P00520
Ratte ABL1 ABL1 311860  

Weitere Synonyme anzeigen

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Am meisten referenzierte ABL1 Proteine

  1. Human ABL1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004077 : Wisniewski, Strife, Swendeman, Erdjument-Bromage, Geromanos, Kavanaugh, Tempst, Clarkson et al.: A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic ... in Blood 1999 (PubMed)
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Weitere Proteine zu ABL1 Interaktionspartnern

Human C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Interaktionspartner

  1. We demonstrate that nanopore technology is suitable for employment in the hematology laboratory for detecting BCR (zeige BCR Proteine)-ABL1 kinase domain mutation in Philadelphia-positive leukemias.

  2. Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (zeige APOB Proteine) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP (zeige MTTP Proteine) is required for secretion of intact APOB (zeige APOB Proteine) but not of truncated APOB (zeige APOB Proteine). (APOB (zeige APOB Proteine) = apolipoprotein B (zeige APOB Proteine); MTTP (zeige MTTP Proteine) = microsomal triglyceride transfer protein (zeige MTTP Proteine))

  3. Frequent molecular monitoring and intervention are required for patients who do not show a reduction in BCR (zeige BCR Proteine)-ABL1 transcripts to these levels after stem cell transplantation.

  4. c-Abl promotes TGF-beta (zeige TGFB1 Proteine)-induced SKIP/Smad3 (zeige SMAD3 Proteine) interaction.

  5. Data indicate the feasibility of detecting ABL1 mutations in cerebrospinal fluid (CSF (zeige CSF2 Proteine)) by next-generation sequencing (NGS) in patients with central nervous system relapse in BCR (zeige BCR Proteine)-ABL1-positive acute lymphoblastic leukemia.

  6. the e13a2 BCR (zeige BCR Proteine)-ABL1 fusion transcript affects the rate, the depth, and the speed of the response to treatment with imatinib firstline, and that including the transcript type in the calculation of the baseline risk scores may improve prognostic stratification and may help the choice of the best treatment policy.

  7. Normal ABL1 is a tumor suppressor in BCR (zeige BCR Proteine)-ABL1-induced leukemia. Allosteric stimulation of the normal ABL1 kinase (zeige BCR Proteine) activity enhanced the antileukemia effect of ABL1 tyrosine kinase inhibitors.

  8. the ABL family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.

  9. 6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (zeige BCL11A Proteine) cells and can be regulated by BCR/ABL signal transduction through downstream phosphoinositide 3-kinase/Akt (zeige AKT1 Proteine) and Janus kinase/signal transducer and activator of transcription (zeige STAT1 Proteine) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (zeige BCL11A Proteine).

  10. ETV6 (zeige ETV6 Proteine)-ABL1 fusion occurs in both lymphoid and myeloid leukemias; the genomic profile and clinical behavior resemble BCR (zeige BCR Proteine)-ABL1-positive malignancies, including the unfavorable prognosis, particularly of acute leukemias. The poor outcome suggests that treatment with tyrosine kinase (zeige TXK Proteine) inhibitors should be considered for patients with this fusion.

Mouse (Murine) C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Interaktionspartner

  1. ABL potentiated the assembly and activation of the RUNX2 (zeige RUNX2 Proteine)-TAZ (zeige TAZ Proteine) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (zeige PPARG Proteine)-mediated adipogenesis.

  2. Normal ABL1 is a tumor suppressor in BCR (zeige BCR Proteine)-ABL1-induced leukemia. ABL1 inhibits expansion and proliferation of BCR (zeige BCR Proteine)-ABL1-expressing leukemic stem cells. Allosteric stimulation of the normal ABL1 kinase activity enhanced the antileukemia effect of ABL1 tyrosine kinase (zeige TYRO3 Proteine) inhibitors.

  3. the ABL family of tyrosine kinases rheostatically enhances IRE1alpha's enzymatic activities, thereby potentiating endoplasmic reticulum stress-induced apoptosis.

  4. p38a (zeige MAPK14 Proteine) as a major substrate of c-Abl both in vitro and in vivo and c-Abl-mediated phosphorylation is critical for the dimerization of p38a (zeige MAPK14 Proteine).

  5. Our data show that: i) HDAC2 (zeige HDAC2 Proteine) levels and activity are increased in NPC (zeige NPC1 Proteine) neuronal models and in Npc1 (zeige NPC1 Proteine)(-/-) mice; ii) inhibition of c-Abl or c-Abl deficiency prevents the increase of HDAC2 (zeige HDAC2 Proteine) protein levels and activity in NPC (zeige NPC1 Proteine) neuronal models

  6. The resistance in BCR (zeige BCR Proteine)-ABL1 cells resulted either from the Y253H mutation in the BCR (zeige BCR Proteine)-ABL1 gene or incubation in increasing concentrations of imatinib.

  7. These results reveal a new pathway in the DNA damage response wherein ABL-dependent tyrosine phosphorylation of DGCR8 (zeige DGCR8 Proteine) stimulates the processing of selective primary miRNAs.

  8. These findings connect the EphB signaling pathway to the regulation of intestinal adenoma initiation via Abl kinase.

  9. overexpression of Id2 in primary alveolar epithelial cells promotes proliferation by inhibiting a retinoblastoma protein/c-Abl interaction leading to greater c-Abl activity.

  10. The study demonstrates a previously unrecognized mechanism that controls insulin (zeige INS Proteine) expression through c-Abl-regulated NKx2.2 (zeige Nkx2-2 Proteine) and GLUT2 (zeige SLC2A2 Proteine).

Caenorhabditis elegans (C. elegans) C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Interaktionspartner

  1. MIG-13 (zeige DHPS Proteine)-WAVE pathway provides the major force for directional cell motility, whereas MIG-13 (zeige DHPS Proteine)-WASP (zeige WASL Proteine) partially compensates for its loss, underscoring their coordinated activities in facilitating robust cell migration.

  2. By screening candidate genes involved in Eph (zeige EPHA1 Proteine) signaling, we find that the Eph (zeige EPHA1 Proteine) kinase-independent pathway involves the ABL-1 nonreceptor tyrosine kinase (zeige TYRO3 Proteine) and possibly the phosphatidylinositol 3-kinase pathway

  3. The trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys (zeige LYZ Proteine)-7 and the tyrosine kinase abl-1.

  4. oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 (zeige TP53 Proteine) and EGL-1 independent pathway; the MAPK (zeige MAPK1 Proteine) kinases MEK-1 (zeige MAP2K1 Proteine) and SEK-1 (zeige MAP2K4 Proteine), and the p53 (zeige TP53 Proteine) antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis

  5. findings demonstrate that ABL-1, the C. elegans homolog of the mammalian c-Abl nonreceptor tyrosine kinase (zeige TYRO3 Proteine) ABL1, is required for Shigella flexneri pathogenesis in nematodes

ABL1 Protein Überblick

Protein Überblick

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.

Alternative names and synonyms associated with ABL1

  • c-abl oncogene 1, receptor tyrosine kinase (ABL1)
  • c-abl oncogene 1, non-receptor tyrosine kinase (ABL1)
  • v-abl Abelson murine leukemia viral oncogene homolog 2 (ABL2)
  • v-abl Abelson murine leukemia viral oncogene homolog 2 (abl2)
  • c-abl oncogene 1, non-receptor tyrosine kinase (Abl1)
  • microsomal triglyceride transfer protein (MTTP)
  • Protein ABL-1 (abl-1)
  • Abl Protein
  • ABL1 Protein
  • ABLL Protein
  • AI325092 Protein
  • bcr/abl Protein
  • c-Abl Protein
  • CABL Protein
  • cb272 Protein
  • E430008G22Rik Protein
  • JTK7 Protein
  • MTP Protein
  • p150 Protein
  • v-abl Protein

Bezeichner auf Proteinebene für ABL1

c-abl oncogene 1, receptor tyrosine kinase , v-abl Abelson murine leukemia viral oncogene homolog 1 , Abelson murine leukemia viral (v-abl) oncogene homolog 1 , v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) , tyrosine kinase ABL , Abelson murine leukemia viral (v-abl) oncogene homolog 2 , Abelson tyrosine-protein kinase 2 , arg, Abelson-related , tyrosine-protein kinase ABL2 , v-abl Abelson murine leukemia viral oncogene homolog 2 , arg tyrosine kinase , tyrosine-protein kinase ABL2-like , Abelson tyrosine-protein kinase 1 , bcr/c-abl oncogene protein , proto-oncogene c-Abl , proto-oncogene tyrosine-protein kinase ABL1 , tyrosine-protein kinase ABL1 , Abelson murine leukemia oncogene , abelson murine leukemia viral oncogene homolog 1 , p150 , v-abl Abelson murine leukemia oncogene 1 , v-abl Abelson murine leukemia viral oncogene 1 , microsomal triglyceride transfer protein (large polypeptide, 88kDa) , microsomal triglyceride transfer protein large subunit

GENE ID SPEZIES
280970 Bos taurus
417181 Gallus gallus
464802 Pan troglodytes
491292 Canis lupus familiaris
395410 Gallus gallus
457552 Pan troglodytes
511845 Bos taurus
570636 Danio rerio
717037 Macaca mulatta
100348328 Oryctolagus cuniculus
100463896 Ailuropoda melanoleuca
100543723 Meleagris gallopavo
100588798 Nomascus leucogenys
25 Homo sapiens
540876 Bos taurus
11350 Mus musculus
311860 Rattus norvegicus
4547 Homo sapiens
181261 Caenorhabditis elegans
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