Die folgenden Gennamen und Gensymbole werden für Antigen serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 über verschiedene Spezies hinweg verwendet:

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (serpine1), serine (or cysteine) peptidase inhibitor, clade E, member 1 (Serpine1), plasminogen activator inhibitor 1 (CpipJ_CPIJ011718), plasminogen activator inhibitor 1 (CpipJ_CPIJ016298)

Zu den weiteren Synonymen zählen:

PAI, PAI1, PAI-1, PLANH1, SERPINE1, MGC154415, si:ch211-138a11.1, Planh1, Pai1, PAI1A, Planh, Pai1aa, RATPAI1A

Auf Proteinebene tauchen folgende Bezeichner für Antigen serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 auf:

plasminogen activator inhibitor-1 – plasminogen activator inhibitor, type I – serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 – serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 – serine (or cysteine) proteinase inhibitor, clade E, member 1 – putative plasminogen activator inhibitor-1 – chemokine CCL-C25s – plasminogen activator inhibitor 1-like – plasminogen activator inhibitor 1 – PAI – serpin E1 – endothelial plasminogen activator inhibitor – nexin, plasminogen activator inhibitor type 1 – Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI) – PAI-1 – serine (or cysteine) proteinase inhibitor, member 1 – plasminogen activator inhibitor I

serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 erfüllt eine Reihe von Funktionen:

peptidase inhibitor activity – protease binding – protein binding – serine-type endopeptidase activity – serine-type endopeptidase inhibitor activity – chemokine activity – cytokine activity – receptor binding

serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 spielt in den folgenden Prozessen eine Rolle:

blood coagulation – chronological cell aging – fibrinolysis – regulation of angiogenesis – regulation of cell proliferation – immune response – defense response to Gram-negative bacterium – negative regulation of endopeptidase activity – negative regulation of plasminogen activation – negative regulation of vascular wound healing – positive regulation of angiogenesis – positive regulation of coagulation – positive regulation of receptor-mediated endocytosis – wound healing – cellular response to chemical stimulus – cellular response to lipopolysaccharide – glucose homeostasis – negative regulation of apoptosis – negative regulation of cell adhesion mediated by integrin – negative regulation of cell migration – negative regulation of fibrinolysis – negative regulation of proteolysis – negative regulation of smooth muscle cell migration – positive regulation of blood coagulation – positive regulation of inflammatory response – positive regulation of interleukin-8 production – positive regulation of leukotriene production involved in inflammatory response – positive regulation of monocyte chemotaxis – regulation of receptor activity – response to cytokine stimulus – response to glucocorticoid stimulus – response to reactive oxygen species – tissue regeneration

serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 ist wie folgt lokalisiert:

extracellular region – plasma membrane – extracellular space – soluble fraction – extracellular matrix

Quelle: NCBI Entrez Gene, Gene Ontology