Die folgenden Gennamen und Gensymbole werden für Antigen Zinc Finger E-Box Binding Homeobox 1 über verschiedene Spezies hinweg verwendet:

zinc finger E-box binding homeobox 1 (ZEB1), zinc finger E-box binding homeobox 1 (Zeb1), zinc finger E-box binding homeobox 1 (zeb1), zinc finger E-box binding homeobox 1 (LOC100226179)

Zu den weiteren Synonymen zählen:

BZP, ZEB, TCF8, AREB6, NIL2A, ZFHEP, NIL-2A, ZFHX1A, NIL-2-A, DELTA-EF1, MGC133261, MEB1, Nil2, Tcf8, Tcf18, Zfhep, Zfx1a, Zfhx1a, Zfx1ha, [delta]EF1, 3110032K11Rik, deltaEF1, zfhx1, kheper, ZFH/[d]EF1, bzp, zeb, tcf8, areb6, nil2a, zfhep, nil-2a, MGC82910, ZEB1, zfhx1a, nil-2-a, MGC97552, DKFZp469P2021

Auf Proteinebene tauchen folgende Bezeichner für Antigen Zinc Finger E-Box Binding Homeobox 1 auf:

zinc finger E-box binding homeobox 1 – zinc finger homeodomain enhancer-binding protein – transcription factor 8 (represses interleukin 2 expression) – transcription factor 8 – zinc finger homeobox 1a – zinc finger E-box-binding homeobox 1 – TCF-8 – zfhep – zfhx1a – zinc finger homeobox 1 – deltaEF1 – zinc finger E-box-binding homeobox 1-like

Zinc Finger E-Box Binding Homeobox 1 erfüllt eine Reihe von Funktionen:

metal ion binding – sequence-specific DNA binding – transcription coactivator activity – transcription corepressor activity – transcription factor activity – zinc ion binding – DNA binding – chromatin binding – nucleic acid binding – protein binding – transcription factor binding – transcription regulator activity – double-stranded DNA binding – sequence-specific DNA binding transcription factor activity

Zinc Finger E-Box Binding Homeobox 1 spielt in den folgenden Prozessen eine Rolle:

cell proliferation – immune response – negative regulation of transcription from RNA polymerase II promoter – cartilage development – central nervous system development – embryonic camera-type eye morphogenesis – embryonic morphogenesis – embryonic skeletal system morphogenesis – negative regulation of cell proliferation – negative regulation of epithelial cell differentiation – pattern specification process – positive regulation of transcription from RNA polymerase II promoter – regulation of T cell differentiation in the thymus – regulation of mesenchymal cell proliferation – regulation of smooth muscle cell differentiation – regulation of transcription – regulation of transcription, DNA-dependent – regulation of transforming growth factor beta receptor signaling pathway – transcription – cellular response to transforming growth factor beta stimulus – forebrain development – negative regulation of transcription – response to activity – response to nutrient levels

Zinc Finger E-Box Binding Homeobox 1 ist wie folgt lokalisiert:

intracellular – nucleus – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology