Die folgenden Gennamen und Gensymbole werden für Antigen Wilms Tumor 1 über verschiedene Spezies hinweg verwendet:

Wilms tumor 1 (WT1), Wilms tumor 1 (wt1-A), wilms tumor 1b (wt1b), Wilms tumor 1 (wt1), Wilms tumor 1 (Wt1), Wilms tumor 1 (LOC100346776), Wilms tumor protein (wt1)

Zu den weiteren Synonymen zählen:

GUD, WAGR, WT33, WIT-2, WT1, WT, wt1-A, xWT1, CWT1, WT-1, wt1, MGC152697, zgc:152697, si:ch211-160j6.3, gud, wagr, wt-1, wt33, xwt1, wit-2

Auf Proteinebene tauchen folgende Bezeichner für Antigen Wilms Tumor 1 auf:

Wilms tumor 1 – OTTHUMP00000037553 – Chick Wilm's tumour protein – wilms tumor 1b – Wilms tumor suppressor protein 1b – Wilms tumor protein homolog – Wilms tumor protein

Wilms Tumor 1 erfüllt eine Reihe von Funktionen:

metal ion binding – promoter binding – transcription activator activity – transcription factor activity – zinc ion binding – nucleic acid binding – C2H2 zinc finger domain binding – RNA binding – double-stranded DNA binding – protein binding – sequence-specific DNA binding – sequence-specific DNA binding transcription factor activity – specific transcriptional repressor activity – transcription repressor activity

Wilms Tumor 1 spielt in den folgenden Prozessen eine Rolle:

negative regulation of transcription from RNA polymerase II promoter – regulation of transcription, DNA-dependent – pronephros development – RNA splicing – adrenal gland development – branching involved in ureteric bud morphogenesis – camera-type eye development – epithelial cell differentiation – germ cell development – glomerular basement membrane development – glomerular visceral epithelial cell differentiation – glomerulus development – heart development – induction of apoptosis – kidney development – male genitalia development – male gonad development – mesenchymal to epithelial transition – mesonephros development – metanephric S-shaped body morphogenesis – metanephros development – negative regulation of apoptosis – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of gene-specific transcription – negative regulation of transcription – negative regulation of translation – positive regulation of gene-specific transcription – positive regulation of transcription – positive regulation of transcription from RNA polymerase II promoter – regulation of transcription from RNA polymerase II promoter – sex determination – tissue development – ureteric bud development – vasculogenesis – visceral serous pericardium development

Wilms Tumor 1 ist wie folgt lokalisiert:

intracellular – nucleus – cytoplasm – nuclear speck – nucleoplasm

Quelle: NCBI Entrez Gene, Gene Ontology