Die folgenden Gennamen und Gensymbole werden für Antigen Vascular Endothelial Growth Factor A über verschiedene Spezies hinweg verwendet:

vascular endothelial growth factor A (VEGFA), vascular endothelial growth factor A (Vegfa), vascular endothelial growth factor Aa (vegfaa), vascular endothelial growth factor (vegf-A), vascular endothelial growth factor A (vegfa)

Zu den weiteren Synonymen zählen:

VPF, VEGF, MVCD1, VEGF-A, MGC70609, Vpf, Vegf, Vegf120, Vegf164, Vegf188, vegf, vegfa, wu:fj82c06, VEGF164, vegf-A, VEGFA, vpf, vefg, vegf-a

Auf Proteinebene tauchen folgende Bezeichner für Antigen Vascular Endothelial Growth Factor A auf:

vascular endothelial growth factor A – vascular permeability factor – vascular endothelial growth factor isoform VEGF165 – OTTMUSP00000017463 – OTTMUSP00000017464 – OTTMUSP00000022243 – OTTMUSP00000022244 – OTTMUSP00000022245 – vegf-a – etID309976.16 – VPF – VEGF-A – vascular endothelial growth factor 188 – angiogenic factor

Vascular Endothelial Growth Factor A erfüllt eine Reihe von Funktionen:

cell surface binding – cytokine activity – extracellular matrix binding – fibronectin binding – growth factor activity – heparin binding – platelet-derived growth factor receptor binding – protein homodimerization activity – vascular endothelial growth factor receptor 1 binding – vascular endothelial growth factor receptor 2 binding – protein binding – protein heterodimerization activity – vascular endothelial growth factor receptor binding – chemoattractant activity

Vascular Endothelial Growth Factor A spielt in den folgenden Prozessen eine Rolle:

angiogenesis – induction of positive chemotaxis – multicellular organismal development – negative regulation of apoptosis – nervous system development – platelet-derived growth factor receptor signaling pathway – positive regulation of blood vessel endothelial cell migration – positive regulation of cell division – positive regulation of endothelial cell proliferation – positive regulation of leukocyte migration – positive regulation of vascular endothelial growth factor receptor signaling pathway – regulation of cell shape – response to hypoxia – vasculogenesis – T-helper 1 type immune response – anti-apoptosis – artery morphogenesis – behavior – blood vessel development – blood vessel morphogenesis – blood vessel remodeling – branching morphogenesis of a tube – camera-type eye morphogenesis – cardiac muscle fiber development – cell differentiation – cell maturation – cell migration – cell proliferation – cellular response to hypoxia – epithelial cell differentiation – eye photoreceptor cell development – growth – heart morphogenesis – in utero embryonic development – kidney development – lactation – lung alveolus development – lung development – mRNA stabilization – mammary gland alveolus development – mesoderm development – negative regulation of bone resorption – ovarian follicle development – patterning of blood vessels – positive regulation of branching involved in ureteric bud morphogenesis – positive regulation of cell proliferation – positive regulation of epithelial cell proliferation – positive regulation of mesenchymal cell proliferation – positive regulation of signal transduction – positive regulation of smooth muscle cell proliferation – positive regulation of transcription from RNA polymerase II promoter – positive regulation of vascular permeability – post-embryonic camera-type eye development – primitive erythrocyte differentiation – surfactant homeostasis – vascular endothelial growth factor receptor signaling pathway – vasculature development – activation of phospholipase C activity – blood vessel endothelial cell proliferation during sprouting angiogenesis – hemopoiesis – motor axon guidance – pronephros development – protein kinase B signaling cascade – regulation of heart contraction – sprouting angiogenesis – thyroid gland development – negative regulation of programmed cell death – positive regulation of angiogenesis – positive regulation of cell migration – positive regulation of cellular component movement – positive regulation of endothelial cell migration – positive regulation of peptidyl-tyrosine phosphorylation – positive regulation of positive chemotaxis – response to cold – blood vessel maturation

Vascular Endothelial Growth Factor A ist wie folgt lokalisiert:

cell surface – extracellular region – extracellular space – membrane – platelet alpha granule lumen – proteinaceous extracellular matrix – basement membrane – cytoplasm – membrane-bounded vesicle – plasma membrane – stored secretory granule

Quelle: NCBI Entrez Gene, Gene Ontology