Die folgenden Gennamen und Gensymbole werden für Antigen V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 3, P65 über verschiedene Spezies hinweg verwendet:

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1), nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (Nfkb1), v-rel reticuloendotheliosis viral oncogene homolog A (rela), nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (nfkb1), v-rel reticuloendotheliosis viral oncogene homolog A (avian) (RELA)

Zu den weiteren Synonymen zählen:

p50, KBF1, p105, EBP-1, MGC54151, NFKB-p50, NF-kappaB, NFKB-p105, NF-kappa-B, DKFZp686C01211, NF-kB, NF-KB1, Xrel1, nfkb3, xrela, MGC69459, NFKB1, kbf1, ebp-1, MGC86262, nfkb-p50, nf-kappaB, nfkb-p105, nf-kappa-b, RELA, p65, NFKB3, MGC131774

Auf Proteinebene tauchen folgende Bezeichner für Antigen V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 3, P65 auf:

nuclear factor kappa-B, subunit 1 – NF-kappabeta – DNA binding factor KBF1 – nuclear factor NF-kappa-B p50 subunit – nuclear factor kappa-B DNA binding subunit – nuclear factor NF-kappa-B p105 subunit – EBP-1 – NF-kappaB – DNA-binding factor KBF1 – nuclear factor kappa B p105 subunit – nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 – nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 – NF-kB p50 subunit – nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) – v-rel reticuloendotheliosis viral oncogene homolog A – v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 – nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 – NF-kappaB transcription factor p65 subunit – nuclear factor of kappa light polypeptide enhancer in B-cells 1 – nuclear factor kappa-B 1 – nuclear factor NF-kappa-B p105 subunit-like – nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 – v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)) – v-rel reticuloendotheliosis viral oncogene homolog A (avian)

V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 3, P65 erfüllt eine Reihe von Funktionen:

promoter binding – protein binding – protein homodimerization activity – specific transcriptional repressor activity – transcription factor activity – actin binding – double-stranded DNA binding – heat shock protein binding – protein dimerization activity – sequence-specific DNA binding – transcription activator activity – DNA binding – sequence-specific DNA binding transcription factor activity – NF-kappaB binding – RNA polymerase II transcription factor activity, enhancer binding – identical protein binding – phosphate binding – protein N-terminus binding – protein kinase binding – transcription activator binding – transcription repressor binding

V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 3, P65 spielt in den folgenden Prozessen eine Rolle:

anti-apoptosis – apoptosis – inflammatory response – membrane protein intracellular domain proteolysis – negative regulation of calcidiol 1-monooxygenase activity – negative regulation of cellular protein metabolic process – negative regulation of cholesterol transport – negative regulation of cytokine production – negative regulation of gene-specific transcription from RNA polymerase II promoter – negative regulation of interleukin-12 biosynthetic process – negative regulation of transcription, DNA-dependent – negative regulation of vitamin D biosynthetic process – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of lipid storage – positive regulation of macrophage derived foam cell differentiation – positive regulation of transcription – signal transduction – positive regulation of transcription from RNA polymerase II promoter – regulation of transcription – regulation of transcription, DNA-dependent – response to copper ion – response to oxidative stress – cellular defense response – cytokine-mediated signaling pathway – defense response to virus – hair follicle development – interspecies interaction between organisms – liver development – negative regulation of protein catabolic process – organ morphogenesis – positive regulation of I-kappaB kinase/NF-kappaB cascade – positive regulation of NF-kappaB transcription factor activity – positive regulation of interleukin-12 biosynthetic process – response to UV-B – response to interleukin-1 – response to organic substance

V-Rel Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 3, P65 ist wie folgt lokalisiert:

I-kappaB/NF-kappaB complex – cytoplasm – cytosol – nucleoplasm – nucleus – protein complex – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology