Die folgenden Gennamen und Gensymbole werden für Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) über verschiedene Spezies hinweg verwendet:

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)

Zu den weiteren Synonymen zählen:

Neu, HER2, HER-2, c-neu, Erbb-2, c-erbB2, mKIAA3023, NEU, NGL, TKR1, CD340, HER-2/neu

Auf Proteinebene tauchen folgende Bezeichner für Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) auf:

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog – Neu oncogene – OTTMUSP00000002540 – avian erythroblastosis oncogene B 2 – receptor tyrosine-protein kinase erbB-2 – erbB-2 – c-erbB-2 – p185erbB2 – proto-oncogene c-ErbB-2 – herstatin – c-erb B2/neu protein – neuroblastoma/glioblastoma derived oncogene homolog – v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) erfüllt eine Reihe von Funktionen:

ATP binding – kinase activity – nucleotide binding – protein binding – protein kinase activity – protein tyrosine kinase activity – receptor activity – receptor signaling protein tyrosine kinase activity – transferase activity – transmembrane receptor protein tyrosine kinase activity – ErbB-3 class receptor binding – epidermal growth factor receptor activity – growth factor binding – identical protein binding – protein C-terminus binding – protein heterodimerization activity – protein phosphatase binding – transmembrane receptor activity

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) spielt in den folgenden Prozessen eine Rolle:

cell surface receptor linked signal transduction – heart development – motor axon guidance – myelination – negative regulation of immature T cell proliferation in the thymus – nervous system development – neuromuscular junction development – peripheral nervous system development – protein amino acid phosphorylation – transmembrane receptor protein tyrosine kinase signaling pathway – cell proliferation – mammary gland development – phosphoinositide 3-kinase cascade – phosphoinositide-mediated signaling – positive regulation of MAP kinase activity – positive regulation of cell adhesion – positive regulation of epithelial cell proliferation – protein amino acid autophosphorylation – regulation of angiogenesis – wound healing

V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) ist wie folgt lokalisiert:

apical plasma membrane – cytoplasm – integral to membrane – membrane – basolateral plasma membrane – plasma membrane – receptor complex

Quelle: NCBI Entrez Gene, Gene Ontology