Die folgenden Gennamen und Gensymbole werden für Antigen Tumor Protein P53 über verschiedene Spezies hinweg verwendet:

tumor protein p53 (TP53), cellular tumor antigen p53 (CpipJ_CPIJ002758), tumor protein p53 (Tp53), tumor protein p53 (tp53), transformation related protein 53 (Trp53), tumor supressor p53 (tp53)

Zu den weiteren Synonymen zählen:

p53, LFS1, TRP53, FLJ92943, P53, Trp53, MGC112612, brp53, drp53, fb40d06, wu:fb40d06, zgc:111919, TP53, bbl, bfy, bhy, p44, Tp53, tp53

Auf Proteinebene tauchen folgende Bezeichner für Antigen Tumor Protein P53 auf:

tumor protein p53 – p53 antigen – phosphoprotein p53 – p53 tumor suppressor – p53 transformation suppressor – transformation-related protein 53 – cellular tumor antigen p53 – tumor suppressor p53 – p53 protein – Cellular tumor antigen p53 – transformation related protein 53 – tumor protein p53 (Li-Fraumeni syndrome) – etID22686.5 – tumor suppressor homolog p53 – p53 tumor suppressor phosphoprotein – tumor suppressor protein – OTTMUSP00000006194 – tumor supressor p53 – p53 cellular tumor antigen – Tumor suppressor p53

Tumor Protein P53 erfüllt eine Reihe von Funktionen:

ATP binding – DNA strand annealing activity – chaperone binding – chromatin binding – copper ion binding – enzyme binding – metal ion binding – promoter binding – protein N-terminus binding – protein heterodimerization activity – transcription factor activity – transcription factor binding – zinc ion binding – DNA binding – RNA polymerase II transcription factor activity – histone acetyltransferase binding – histone deacetylase regulator activity – protease binding – protein C-terminus binding – protein binding – protein kinase binding – protein phosphatase 2A binding – sequence-specific DNA binding – sequence-specific DNA binding transcription factor activity – transcription activator activity – transcription repressor activity – ubiquitin protein ligase binding – transcription regulator activity

Tumor Protein P53 spielt in den folgenden Prozessen eine Rolle:

B cell lineage commitment – DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis – ER overload response – G1 DNA damage checkpoint – T cell differentiation in the thymus – T cell lineage commitment – T cell proliferation during immune response – activation of caspase activity by cytochrome c – base-excision repair – cell aging – cell cycle – cell cycle arrest – cell differentiation – cell proliferation – cellular response to UV – cellular response to glucose starvation – central nervous system development – chromosome organization – double-strand break repair – embryonic development ending in birth or egg hatching – gastrulation – in utero embryonic development – induction of apoptosis by intracellular signals – interspecies interaction between organisms – multicellular organismal development – negative regulation of DNA replication – negative regulation of apoptosis – negative regulation of cell growth – negative regulation of fibroblast proliferation – negative regulation of helicase activity – negative regulation of neuroblast proliferation – negative regulation of transcription from RNA polymerase II promoter – nucleotide-excision repair – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of neuron apoptosis – protein complex assembly – protein import into nucleus, translocation – protein localization – protein tetramerization – regulation of intracellular pH – regulation of mitochondrial membrane permeability – regulation of transcription, DNA-dependent – release of cytochrome c from mitochondria – response to DNA damage stimulus – response to X-ray – response to drug – response to gamma radiation – response to salt stress – response to tumor cell – DNA damage response, signal transduction by p53 class mediator – DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest – DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator – Ras protein signal transduction – T cell proliferation involved in immune response – aging – apoptosis – embryo development ending in birth or egg hatching – induction of apoptosis – mitotic cell cycle G1/S DNA damage checkpoint – multicellular organism growth – negative regulation of cell proliferation – negative regulation of smooth muscle cell proliferation – negative regulation of transforming growth factor beta receptor signaling pathway – positive regulation of apoptosis – positive regulation of cell cycle – positive regulation of histone deacetylation – positive regulation of leukocyte migration – positive regulation of transcription – positive regulation of transcription from RNA polymerase II promoter – positive regulation of transcription, DNA-dependent – rRNA transcription – regulation of apoptosis – regulation of catalytic activity – regulation of cell cycle – regulation of cell proliferation – regulation of neuron apoptosis – regulation of transcription from RNA polymerase II promoter – response to UV – response to amino acid stimulus – response to caffeine – response to chemical stimulus – response to cytokine stimulus – response to hyperoxia – response to inorganic substance – response to metal ion – response to organic cyclic substance – response to organic nitrogen – response to oxidative stress – response to retinoic acid – response to vitamin B3 – somitogenesis – transforming growth factor beta receptor signaling pathway – wound healing – DNA damage checkpoint – negative regulation of cell cycle – positive regulation of caspase activity – regulation of transcription – response to methylmercury – transcription

Tumor Protein P53 ist wie folgt lokalisiert:

PML body – cytoplasm – cytosol – endoplasmic reticulum – insoluble fraction – mitochondrion – nuclear matrix – nucleolus – nucleoplasm – nucleus – replication fork – transcription factor TFIID complex – chromatin – nuclear body – protein complex – soluble fraction – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology