Die folgenden Gennamen und Gensymbole werden für Antigen Tumor Necrosis Factor über verschiedene Spezies hinweg verwendet:

tumor necrosis factor (TNF superfamily, member 2) (TNF), tumor necrosis factor, alpha-induced protein 1 (endothelial) (TNFAIP1), tumor necrosis factor, alpha-induced protein 1 (endothelial) (Tnfaip1), tumor necrosis factor (TNF superfamily, member 2) (Tnf), tumor necrosis factor, alpha-induced protein 1 (endothelial) (tnfaip1), tumor necrosis factor (tnf), tumor necrosis factor (Tnf), tumor necrosis factor (TNF), tumor necrosis factor b (TNF superfamily, member 2) (tnfb), tumor necrosis factor alpha (TNF-ALPHA), tumor necrosis factor (TNF superfamily, member 2) (tnf), tumour necrosis factor alpha-like (tnf-alpha), tumor necrosis factor alpha (tnf-alpha), tumor necrosis factor-like (LOC100397484)

Zu den weiteren Synonymen zählen:

DIF, TNFA, TNFSF2, TNF-alpha, B12, B61, EDP1, MGC2317, Edp1, Edp-1, Tnfip1, Tnfa, RATTNF, MGC124630, zgc:55302, wu:fi06b02, TNFAIP1, TNF, tnf, DKFZp468A2328, Tnfsf1a, TNFalpha, MGC151434, TNFa, cTNF, Tnf-alpha, tnfa-like, TNF-ALPHA, dif, tnfa, xtnf, TNF-a, tnfsf2, tnf-alpha, Cachectin

Auf Proteinebene tauchen folgende Bezeichner für Antigen Tumor Necrosis Factor auf:

tumor necrosis factor alpha – cachectin – APC1 protein – TNF, monocyte-derived – TNF, macrophage-derived – TNF superfamily, member 2 – tumor necrosis factor, alpha-induced protein 1 – BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 – OTTMUSP00000000199 – OTTMUSP00000000200 – tumor necrosis factor induced protein 1 – BTB/POZ domain-containing protein TNFAIP1 – tumor necrosis factor – TNF-a – tumor necrosis factor-alpha – tumor necrosis factor, alpha (cachetin) – tumor necrosis factor superfamily member 2 – tumor necrosis factor superfamily, member 2 – tumor necrosis factor ligand superfamily member 2 – tumor necrosis factor, alpha-induced protein 1 (endothelial) – tumor necrosis factor (TNF superfamily, member 2) – tumor necrosis factor, alpha-induced protein 1-like – BTB/POZ domain-containing protein TNFAIP1-like – TNF alpha – TNF-alpha – tumor necrosis factor, alpha (TNF superfamily, member 2) – tumor-necrosis factor – tumour necrosis factor – TNF2 – ATP-binding cassette, sub-family F (GCN20), member 1 – tumour necrosis factor alpha – putative tumour necrosis factor alpha – tumor necrosis factor-like – Tumor necrosis factor

Tumor Necrosis Factor erfüllt eine Reihe von Funktionen:

cytokine activity – identical protein binding – tumor necrosis factor receptor binding – molecular_function – protein binding – voltage-gated potassium channel activity – promoter binding – transcription activator activity – transcription repressor activity – protein domain specific binding

Tumor Necrosis Factor spielt in den folgenden Prozessen eine Rolle:

activation of MAPK activity – activation of caspase activity – anti-apoptosis – calcium-mediated signaling – cell activation – chronic inflammatory response to antigenic stimulus – defense response to bacterium – glucose metabolic process – humoral immune response – induction of apoptosis via death domain receptors – induction of necroptosis by extracellular signals – inflammatory response – leukocyte tethering or rolling – multicellular organismal development – negative regulation of L-glutamate transport – negative regulation of cell proliferation – negative regulation of cytokine secretion during immune response – negative regulation of glucose import – negative regulation of interleukin-6 production – negative regulation of lipid catabolic process – negative regulation of transcription – negative regulation of transcription from RNA polymerase II promoter – negative regulation of viral genome replication – organ morphogenesis – positive regulation of I-kappaB kinase/NF-kappaB cascade – positive regulation of JNK cascade – positive regulation of NF-kappaB import into nucleus – positive regulation of NF-kappaB transcription factor activity – positive regulation of calcidiol 1-monooxygenase activity – positive regulation of chemokine biosynthetic process – positive regulation of chemokine production – positive regulation of cytokine secretion – positive regulation of gene-specific transcription – positive regulation of hair follicle development – positive regulation of heterotypic cell-cell adhesion – positive regulation of membrane protein ectodomain proteolysis – positive regulation of mitosis – positive regulation of necrotic cell death – positive regulation of neuron apoptosis – positive regulation of nitric oxide biosynthetic process – positive regulation of protein amino acid phosphorylation – positive regulation of protein transport – positive regulation of smooth muscle cell proliferation – positive regulation of synaptic transmission – positive regulation of transcription – positive regulation of transcription from RNA polymerase II promoter – positive regulation of translational initiation by iron – positive regulation of vitamin D biosynthetic process – protein import into nucleus, translocation – receptor biosynthetic process – regulation of immunoglobulin secretion – regulation of insulin secretion – regulation of osteoclast differentiation – response to glucocorticoid stimulus – response to mechanical stimulus – response to salt stress – response to virus – sequestering of triglyceride – signal transduction – transformed cell apoptosis – tumor necrosis factor-mediated signaling pathway – DNA replication – embryonic development – immune response – potassium ion transport – embryo development – JNK cascade – apoptosis – cellular extravasation – defense response – defense response to Gram-positive bacterium – epithelial cell proliferation involved in salivary gland morphogenesis – extracellular matrix organization – induction of apoptosis – induction of apoptosis by extracellular signals – leukocyte migration – necrotic cell death – negative regulation of apoptosis – negative regulation of branching involved in lung morphogenesis – negative regulation of cytokine secretion involved in immune response – negative regulation of gene-specific transcription – negative regulation of growth of symbiont in host – osteoclast differentiation – positive regulation of apoptosis – positive regulation of chronic inflammatory response to antigenic stimulus – positive regulation of cytokine production – positive regulation of fever – positive regulation of humoral immune response mediated by circulating immunoglobulin – positive regulation of inflammatory response – positive regulation of interferon-gamma production – positive regulation of interleukin-18 production – positive regulation of interleukin-6 production – positive regulation of transcription factor activity – regulation of I-kappaB kinase/NF-kappaB cascade – regulation of branching involved in salivary gland morphogenesis – regulation of cell proliferation – regulation of protein amino acid phosphorylation – response to drug – DNA repair – actin cytoskeleton organization – protein heterooligomerization – protein homooligomerization – regulation of DNA replication – regulation of transcription – cell proliferation – positive regulation of cell proliferation

Tumor Necrosis Factor ist wie folgt lokalisiert:

external side of plasma membrane – extracellular region – extracellular space – integral to plasma membrane – membrane raft – phagocytic cup – plasma membrane – recycling endosome – cellular_component – membrane – voltage-gated potassium channel complex – cytoplasm – endosome – nucleus – cell surface – integral to membrane – intracellular – stored secretory granule

Quelle: NCBI Entrez Gene, Gene Ontology