Die folgenden Gennamen und Gensymbole werden für Antigen Titin über verschiedene Spezies hinweg verwendet:

titin (TTN), titin (Ttn), bent (bt), sallimus (sls), connectin (LOC530831), titin (titin), TITIN protein (TITIN)

Zu den weiteren Synonymen zählen:

TMD, CMH9, CMD1G, CMPD4, EOMFC, HMERF, LGMD2J, FLJ26020, FLJ26409, FLJ32040, FLJ34413, FLJ39564, FLJ43066, CONNECTIN, DKFZp451N061, L56, mdm, shru, AF006999, AV006427, 1100001C23Rik, 2310036G12Rik, 2310057K23Rik, 2310074I15Rik, D330041I19Rik, D830007G01Rik, 39c-18, CG10285, CG1479, CT3598, CT8086, Prj, l(2)2, l(2)23, l(4)102CDa, l(4)2, l(4)21, l(4)23, l(4)37, l(4)38, l(4)PT-2, titin, DmelCG32019, CG32019, 0020/01, anon-CREST, CG18242, CG18245, CG18857, CG1915, CT41299, D-titin, D-Titin, DmelCG1915, ket, Ket, KZ, l(3)62Ca, l(3)Ca, l(3)dre8, l(3)j1D7, l(3)rL182, l(3)S002001, MCP, sal, sam, Sls, SLS, Titin, TTN, LOC530831, UNC-22, TITIN

Auf Proteinebene tauchen folgende Bezeichner für Antigen Titin auf:

titin – rhabdomyosarcoma antigen MU-RMS-40.14 – connectin – OTTMUSP00000014129 – OTTMUSP00000016107 – bent, isoform A – CG32019-PA – bt-PA – twitchin – myosin LCK – lethal(4) Powell, Tennessee-2 – projectin myosin light chain kinase – projectin – C-protein – bent, isoform D – CG32019-PD – bt-PD – bent, isoform C – CG32019-PC – bt-PC – bent, isoform E – CG32019-PE – bt-PE – sallimus, isoform C – CG1915-PC – sls-PC – lethal(3)62Ca – mitotic chromosomal protein – lethal (3) S002001 – dtitin – D-titin – salimus – D-titin-KZ – sallimus – kettin – sallimus, isoform A – CG1915-PA – sls-PA – titin protein homolog – TITIN protein

Titin erfüllt eine Reihe von Funktionen:

ATP binding – Rho guanyl-nucleotide exchange factor activity – actin filament binding – alpha-actinin binding – calcium ion binding – calmodulin binding – identical protein binding – magnesium ion binding – nucleotide binding – protein self-association – protein serine/threonine kinase activity – structural constituent of muscle – telethonin binding – transferase activity – protein binding – structural constituent of cytoskeleton – myosin light chain kinase activity – phosphopantetheine binding – actin binding – protein tyrosine kinase activity – protein kinase activity

Titin spielt in den folgenden Prozessen eine Rolle:

cardiac muscle fiber development – cardiac muscle tissue morphogenesis – cardiac myofibril assembly – mitotic chromosome condensation – muscle thick filament assembly – muscle thin filament assembly – protein amino acid phosphorylation – regulation of Rho protein signal transduction – regulation of catalytic activity – regulation of protein kinase activity – response to calcium ion – sarcomere organization – striated muscle contraction – adult heart development – forward locomotion – heart morphogenesis – in utero embryonic development – muscle contraction – striated muscle cell development – carbohydrate metabolic process – mesoderm development – locomotion – muscle attachment – muscle organ development – myoblast fusion – sister chromatid cohesion – skeletal muscle tissue development – skeletal muscle myosin thick filament assembly – skeletal muscle thin filament assembly

Titin ist wie folgt lokalisiert:

Z disc – condensed nuclear chromosome – cytoplasm – cytosol – extracellular region – intracellular – nucleus – A band – I band – M band – muscle myosin complex – myofibril – sarcomere – microtubule associated complex – striated muscle thin filament

Quelle: NCBI Entrez Gene, Gene Ontology