Die folgenden Gennamen und Gensymbole werden für Antigen TGF-beta über verschiedene Spezies hinweg verwendet:

decapentaplegic (dpp), punt (put), transforming growth factor, beta 1 (TGFB1), transforming growth factor, beta 1 (Tgfb1)

Zu den weiteren Synonymen zählen:

BMP, DPP, DPP-C, Dm-DPP, Hin-d, M(2)23AB, M(2)LS1, TGF-b, TGF-beta, TGFbeta, Tg, blk, ho, l(2)10638, l(2)22Fa, l(2)k17036, shv, DmelCG9885, CG9885, Act-r, Atr, Atr-II, Atr88CD, atrII, AtrII, CG7904, dlhC, DmelCG7904, l(3)10460, l(3)j5A5, pun, Punt, Put, STK-C, TGF-B, Tgf-r, TGFB1, Tgfb1

Auf Proteinebene tauchen folgende Bezeichner für Antigen TGF-beta auf:

decapentaplegic, isoform A – CG9885-PA – dpp-PA – shortvein – blink – Decapentaplegic/Bone morphogenetic protein – bone morphogenetic protein – bone morphogenic protein – decapentaplegic – Haplo-insufficient – heldout – tegula – decapentaplegic, isoform B – CG9885-PB – dpp-PB – decapentaplegic, isoform C – CG9885-PC – dpp-PC – decapentaplegic, isoform D – CG9885-PD – dpp-PD – decapentaplegic, isoform E – CG9885-PE – dpp-PE – punt – CG7904-PA – put-PA – dorsal holes C – Activin-A-receptor-88CD – DPP receptor – activin receptor – activin receptor type II – TGF-beta-type-receptor-like – transforming growth factor, beta 1 – transforming growth factor beta1 – transforming growth factor-beta

TGF-beta erfüllt eine Reihe von Funktionen:

growth factor activity – morphogen activity – protein binding – protein heterodimerization activity – protein homodimerization activity – signal transducer activity – specific transcriptional repressor activity – transforming growth factor beta receptor binding – ATP binding – activin binding – activin receptor activity – protein kinase activity – transforming growth factor beta receptor activity – transforming growth factor beta receptor activity, type II

TGF-beta spielt in den folgenden Prozessen eine Rolle:

BMP signaling pathway – amnioserosa formation – anterior/posterior axis specification – anterior/posterior pattern formation, imaginal disc – branch fusion, open tracheal system – branched duct epithelial cell fate determination, open tracheal system – cardioblast differentiation – cell fate determination – cell fate specification – chorion-containing eggshell formation – compound eye morphogenesis – dorsal appendage formation – dorsal closure – dorsal closure, leading edge cell fate determination – dorsal/ventral axis specification – dorsal/ventral pattern formation, imaginal disc – ectoderm development – ectodermal cell fate specification – embryonic development – epithelial cell fate determination, open tracheal system – epithelial cell migration, open tracheal system – eye-antennal disc development – eye-antennal disc morphogenesis – foregut morphogenesis – fusion cell fate specification – genital disc anterior/posterior pattern formation – genital disc development – genital disc sexually dimorphic development – germ cell development – germ-line stem cell division – germ-line stem cell maintenance – heart development – hindgut morphogenesis – imaginal disc development – imaginal disc growth – imaginal disc pattern formation – imaginal disc-derived wing morphogenesis – imaginal disc-derived wing vein morphogenesis – imaginal disc-derived wing vein specification – instar larval development – labial disc development – leg disc proximal/distal pattern formation – lymph gland development – maternal specification of dorsal/ventral axis, oocyte, soma encoded – mesoderm development – negative regulation of cell proliferation – negative regulation of salivary gland boundary specification – nurse cell apoptosis – oogenesis – open tracheal system development – ovarian follicle cell development – pericardial cell differentiation – pigmentation during development – progression of morphogenetic furrow during compound eye morphogenesis – regulation of cell proliferation – regulation of imaginal disc growth – regulation of organ growth – regulation of tube diameter, open tracheal system – sensory organ development – stem cell division – stem cell maintenance – transforming growth factor beta receptor signaling pathway – wing and notum subfield formation – wing disc anterior/posterior pattern formation – wing disc pattern formation – wing disc proximal/distal pattern formation – zygotic determination of anterior/posterior axis, embryo – zygotic determination of dorsal/ventral axis – Malpighian tubule morphogenesis – activin receptor signaling pathway – axon guidance – dendrite morphogenesis – dorsal/ventral pattern formation – head involution – neuron development – primary branching, open tracheal system – protein amino acid phosphorylation

TGF-beta ist wie folgt lokalisiert:

extracellular region – extracellular space – intracellular – activin receptor complex – plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology