Die folgenden Gennamen und Gensymbole werden für Antigen Synuclein, alpha über verschiedene Spezies hinweg verwendet:

synuclein, alpha (non A4 component of amyloid precursor) (SNCA), synuclein, alpha (Snca), synuclein, alpha (non A4 component of amyloid precursor) (Snca), synuclein, alpha (snca), alpha-synuclein (LOC619283), alpha-synuclein (LOC100359228)

Zu den weiteren Synonymen zählen:

PD1, NACP, PARK1, PARK4, MGC110988, alphaSYN, MGC105443, snca, MGC64356, SNCA, LOC619283, MGC127560

Auf Proteinebene tauchen folgende Bezeichner für Antigen Synuclein, alpha auf:

alpha-synuclein – OTTHUMP00000161559 – OTTHUMP00000161561 – alpha-synuclein, isoform NACP140 – non A-beta component of AD amyloid – synuclein, alpha – alpha SYN – synuclein, alpha (non A4 component of amyloid precursor) – alpha synuclein – Alpha-synuclein

Synuclein, alpha erfüllt eine Reihe von Funktionen:

Hsp70 protein binding – alpha-tubulin binding – dynein binding – histone binding – kinesin binding – tau protein binding – transferrin transmembrane transporter activity – arachidonic acid binding – identical protein binding – phospholipase binding – phospholipid binding – protein N-terminus binding – protein binding – protein domain specific binding – calcium ion binding – caspase inhibitor activity – ferrous iron binding – magnesium ion binding – zinc ion binding

Synuclein, alpha spielt in den folgenden Prozessen eine Rolle:

negative regulation of histone acetylation – negative regulation of monooxygenase activity – positive regulation of endocytosis – positive regulation of receptor recycling – receptor internalization – regulation of dopamine secretion – response to interferon-gamma – synaptic vesicle endocytosis – adult locomotory behavior – cellular response to oxidative stress – dopamine biosynthetic process – dopamine metabolic process – fatty acid metabolic process – long-term synaptic potentiation – membrane organization – microglial cell activation – mitochondrial ATP synthesis coupled electron transport – mitochondrial membrane organization – negative regulation of neuron apoptosis – neutral lipid metabolic process – phospholipid metabolic process – positive regulation of neurotransmitter secretion – positive regulation of synaptic transmission – regulation of acyl-CoA biosynthetic process – regulation of excitatory postsynaptic membrane potential – regulation of glutamate secretion – regulation of locomotion – regulation of long-term neuronal synaptic plasticity – regulation of macrophage activation – regulation of neuron apoptosis – regulation of neuronal synaptic plasticity – regulation of neurotransmitter secretion – response to drug – synaptic transmission, dopaminergic – synaptic vesicle transport – behavioral response to cocaine – anti-apoptosis – negative regulation of caspase activity – negative regulation of dopamine uptake – negative regulation of exocytosis – negative regulation of norepinephrine uptake – negative regulation of platelet-derived growth factor receptor signaling pathway – negative regulation of serotonin uptake – negative regulation of thrombin receptor signaling pathway – negative regulation of transporter activity – positive regulation of inositol phosphate biosynthetic process – positive regulation of release of sequestered calcium ion into cytosol – regulation of phospholipase activity – response to interleukin-1 – response to iron(II) ion – response to lipopolysaccharide – response to magnesium ion

Synuclein, alpha ist wie folgt lokalisiert:

actin cytoskeleton – axon – cell cortex – cytoplasm – growth cone – nucleus – plasma membrane – cytoskeleton – cytosol – synaptosome – membrane fraction – microsome – nerve terminal – soluble fraction – synaptic vesicle – terminal button – fibril – platelet alpha granule membrane

Quelle: NCBI Entrez Gene, Gene Ontology

Synuclein, alpha (SNCA) ELISA Kit (ABIN415770) zitiert in Neurobiology of disease

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