Die folgenden Gennamen und Gensymbole werden für Antigen Sonic Hedgehog über verschiedene Spezies hinweg verwendet:

sonic hedgehog homolog (Drosophila) (SHH), sonic hedgehog (Shh), sonic hedgehog a (shha), sonic hedgehog homolog (shh), sonic hedgehog (shh), sonic hedgehog (SHH), sonic hedgehog (LOC100352774)

Zu den weiteren Synonymen zählen:

TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5, Hx, Dsh, Hhg1, Hxl3, M100081, 9530036O11Rik, shh, syu, vhh1, wu:fc83d08, SHH

Auf Proteinebene tauchen folgende Bezeichner für Antigen Sonic Hedgehog auf:

sonic hedgehog – sonic hedgehog protein – HHG-1 – short digits – OTTMUSP00000023583 – hemimelic extra toes – sonic hedgehog homolog – fc83d08 – sonic you – sonic-you – vertebrate hedgehog homolog – morphogen

Sonic Hedgehog erfüllt eine Reihe von Funktionen:

laminin-1 binding – patched binding – peptidase activity – protein binding – glycoprotein binding – glycosaminoglycan binding – hydrolase activity – transcription activator activity – calcium ion binding – receptor binding – signal transducer activity – zinc ion binding

Sonic Hedgehog spielt in den folgenden Prozessen eine Rolle:

Bergmann glial cell differentiation – androgen metabolic process – anterior/posterior pattern formation – axon guidance – blood coagulation – branching involved in ureteric bud morphogenesis – camera-type eye development – cell fate specification – cell-cell signaling – developmental growth – digestive tract morphogenesis – dorsal/ventral neural tube patterning – embryonic digit morphogenesis – embryonic organ development – embryonic skeletal system development – epithelial-mesenchymal signaling involved in prostate gland development – forebrain development – formation of anatomical boundary – hair follicle morphogenesis – heart development – hindbrain development – hindgut morphogenesis – intein-mediated protein splicing – lung development – male genitalia development – metanephros development – midbrain development – myoblast differentiation – negative regulation of T cell proliferation – negative regulation of alpha-beta T cell differentiation – negative regulation of cell differentiation – negative regulation of cell migration – negative regulation of proteasomal ubiquitin-dependent protein catabolic process – negative regulation of protein catabolic process – neural crest cell migration – neural tube formation – neuron fate commitment – odontogenesis of dentine-containing tooth – oligodendrocyte development – open tracheal system development – osteoblast development – patterning of blood vessels – positive regulation of granule cell precursor proliferation – positive regulation of hh target transcription factor activity – positive regulation of mesenchymal cell proliferation – positive regulation of neuroblast proliferation – positive regulation of neuron differentiation – positive regulation of protein import into nucleus – positive regulation of transcription from RNA polymerase II promoter – regulation of epithelial cell differentiation – regulation of proteolysis – regulation of transcription – response to axon injury – salivary gland morphogenesis – signal transduction – smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation – spinal cord dorsal/ventral patterning – striated muscle cell differentiation – telencephalon regionalization – tongue morphogenesis – vasculogenesis – ventral midline development – anatomical structure development – anatomical structure formation involved in morphogenesis – angiogenesis – apoptosis – artery development – branching involved in prostate gland morphogenesis – branching involved in salivary gland morphogenesis – branching morphogenesis of a tube – bud outgrowth involved in lung branching – canonical Wnt receptor signaling pathway – cell communication – cell death – cell development – cell fate commitment – cell proliferation – cellular response to lithium ion – central nervous system development – determination of left/right symmetry – digestive tract mesoderm development – dorsal/ventral pattern formation – ectoderm development – embryo development – embryo sac morphogenesis – embryonic digestive tract morphogenesis – embryonic foregut morphogenesis – embryonic forelimb morphogenesis – embryonic hindlimb morphogenesis – embryonic limb morphogenesis – embryonic morphogenesis – endocytosis – epithelial cell proliferation involved in salivary gland morphogenesis – epithelial tube branching involved in lung morphogenesis – epithelial-mesenchymal cell signaling – establishment of cell polarity – hair follicle development – heart looping – inner ear development – intermediate filament organization – kidney development – left lung development – limb bud formation – limb development – lung epithelium development – lung lobe morphogenesis – lung morphogenesis – lung-associated mesenchyme development – male genitalia morphogenesis – mesenchymal cell proliferation – mesenchymal cell proliferation involved in lung development – mesenchymal smoothened signaling pathway involved in prostate gland development – multicellular organismal development – multicellular structure septum development – myotube differentiation – negative regulation of Wnt receptor signaling pathway – negative regulation of apoptosis – negative regulation of canonical Wnt receptor signaling pathway – negative regulation of gene-specific transcription elongation from RNA polymerase II promoter – negative regulation of gene-specific transcription from RNA polymerase II promoter – negative regulation of smooth muscle cell differentiation – neuroblast proliferation – odontogenesis – oligodendrocyte differentiation – organ formation – palate development – pancreas development – pattern specification process – positive regulation of Wnt receptor signaling pathway – positive regulation of cell differentiation – positive regulation of cell proliferation – positive regulation of epithelial cell proliferation involved in prostate gland development – positive regulation of gene expression – positive regulation of gene-specific transcription – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of oligodendrocyte differentiation – positive regulation of oligodendrocyte progenitor proliferation – positive regulation of penile erection – positive regulation of photoreceptor cell differentiation – positive regulation of skeletal muscle cell proliferation – positive regulation of skeletal muscle tissue development – positive regulation of smooth muscle cell differentiation – positive regulation of striated muscle cell differentiation – primary prostatic bud elongation – prostate epithelial cord elongation – prostate gland development – prostatic bud formation – proteolysis – regulation of cell proliferation – regulation of epithelial cell proliferation involved in prostate gland development – regulation of gene expression – regulation of mesenchymal cell proliferation involved in prostate gland development – regulation of mesenchymal cell proliferation involved in ureter development – regulation of prostatic bud formation – respiratory tube development – response to ethanol – right lung development – salivary gland cavitation – skin development – smoothened signaling pathway – stem cell development – striated muscle tissue development – thyroid gland development – trachea development – trachea morphogenesis – ureter smooth muscle cell differentiation – vasculature development – ventral spinal cord interneuron specification – response to estradiol stimulus – response to hypoxia – response to organic nitrogen – response to retinoic acid – sclerotome development – adenohypophysis development – blood circulation – brain development – cardioblast differentiation – caudal fin morphogenesis – diencephalon development – embryonic camera-type eye development – embryonic gut morphogenesis – embryonic neurocranium morphogenesis – embryonic viscerocranium morphogenesis – endocrine pancreas development – eye photoreceptor cell development – floor plate development – floor plate formation – glial cell differentiation – gliogenesis – glomerulus development – muscle cell fate specification – muscle organ development – negative regulation of cell proliferation – nervous system development – neural plate morphogenesis – neuron differentiation – pectoral fin development – post-embryonic foregut morphogenesis – regulation of vascular endothelial growth factor receptor signaling pathway – skeletal muscle fiber development – somitogenesis – striated muscle cell development

Sonic Hedgehog ist wie folgt lokalisiert:

anchored to membrane – cell surface – extracellular region – extracellular space – membrane raft – plasma membrane – Golgi apparatus – endoplasmic reticulum – extracellular matrix – membrane – membrane fraction – nucleus – transport vesicle

Quelle: NCBI Entrez Gene, Gene Ontology