Die folgenden Gennamen und Gensymbole werden für Antigen Slit Homolog 2 (Drosophila) über verschiedene Spezies hinweg verwendet:

slit homolog 2 (Drosophila) (SLIT2), slit homolog 2 (Drosophila) (Slit2), slit (Drosophila) homolog 2 (slit2), slit homolog 2 (Drosophila) (slit2-a)

Zu den weiteren Synonymen zählen:

SLIL3, Slit-2, FLJ14420, Slil3, Drad-1, KIAA4141, mKIAA4141, E030015M03Rik, E130320P19Rik, Slit, slit2-a

Auf Proteinebene tauchen folgende Bezeichner für Antigen Slit Homolog 2 (Drosophila) auf:

slit homolog 2 – slit homolog 2 protein – slit-2 – neurogenic extracellular slit protein – downregulated during adipocyte differentiation-1 – slit homolog 2 (Drosophila)

Slit Homolog 2 (Drosophila) erfüllt eine Reihe von Funktionen:

calcium ion binding – receptor binding – chemorepellent activity – heparan sulfate proteoglycan binding – protein binding – GTPase inhibitor activity – Roundabout binding – follicle-stimulating hormone receptor activity – heparin binding – laminin-1 binding – protein homodimerization activity – proteoglycan binding

Slit Homolog 2 (Drosophila) spielt in den folgenden Prozessen eine Rolle:

cell differentiation – cell migration involved in sprouting angiogenesis – chemotaxis – glial cell migration – induction of negative chemotaxis – mesoderm migration – motor axon guidance – multicellular organismal development – nervous system development – neuron recognition – positive regulation of axonogenesis – sensory perception of smell – ureteric bud development – axon guidance – axonogenesis – cell-cell adhesion – dorsal/ventral axon guidance – in utero embryonic development – mammary duct terminal end bud growth – mammary gland duct morphogenesis – metanephros development – negative chemotaxis – negative regulation of cell proliferation – negative regulation of gene expression – negative regulation of inflammatory response – neuron projection morphogenesis – olfactory bulb development – retinal ganglion cell axon guidance – telencephalon cell migration – axonal defasciculation – morphogenesis of a branching structure – negative regulation of axon extension – G-protein coupled receptor protein signaling pathway – Roundabout signaling pathway – axon extension involved in axon guidance – brain development – branching morphogenesis of a tube – cellular response to heparin – cellular response to hormone stimulus – chemorepulsion involved in embryonic olfactory bulb interneuron migration – chemorepulsion involved in postnatal olfactory bulb interneuron migration – corticospinal neuron axon guidance through the spinal cord – luteolysis – negative regulation of actin filament polymerization – negative regulation of cell growth – negative regulation of cell migration – negative regulation of cellular response to growth factor stimulus – negative regulation of chemokine-mediated signaling pathway – negative regulation of endothelial cell migration – negative regulation of lamellipodium assembly – negative regulation of leukocyte chemotaxis – negative regulation of mononuclear cell migration – negative regulation of neutrophil chemotaxis – negative regulation of protein amino acid phosphorylation – negative regulation of retinal ganglion cell axon guidance – negative regulation of small GTPase mediated signal transduction – negative regulation of smooth muscle cell chemotaxis – negative regulation of smooth muscle cell migration – negative regulation of vascular permeability – positive regulation of apoptosis – response to cortisol stimulus – response to nutrient levels – spinal cord development – eye development – limb development – neural tube development

Slit Homolog 2 (Drosophila) ist wie folgt lokalisiert:

extracellular region – extracellular space – plasma membrane – cell surface – cytoplasm – integral to membrane

Quelle: NCBI Entrez Gene, Gene Ontology