Die folgenden Gennamen und Gensymbole werden für Antigen Sirtuin 2 über verschiedene Spezies hinweg verwendet:

sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2), Sirt2 (Sirt2), sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (Sirt2), sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2), sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (Sirt2), sirtuin 2 (sir2), NAD-dependent deacetylase sirtuin 2 homolog (Sirt2), SRT2 (SIRTUIN 2); DNA binding / NAD or NADH binding / NAD-dependent histone deacetylase/ zinc ion binding (SRT2), sirtuin (silent mating type information regulation 2 homolog) 2 (SIRT2)

Zu den weiteren Synonymen zählen:

SIR2, SIR2L, SIR2L2, D.mel2, dSIRT2, DmelCG5085, CG5085, Sir2l, 5730427M03Rik, zgc:55966, zgc:77003, wu:fb57d05, MGC105900, SIRT2, sir2, Sirt2, BmSirt2, SIRTUIN 2, SRT2, T2K12.8, DKFZp468D2413

Auf Proteinebene tauchen folgende Bezeichner für Antigen Sirtuin 2 auf:

sirtuin 2 – sirtuin type 2 – sir2-related protein type 2 – silent information regulator 2 – silencing information regulator 2-like – Sirt2 – CG5085-PA – Sirt2-PA – NAD-dependent deacetylase sirtuin-2 – mSIR2L2 – OTTMUSP00000018858 – SIR2-like protein 2 – silent mating type information regulation 2, (S.cerevisiae, homolog)-like – silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 – 5E5 antigen – sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) – sirtuin-like protein 2 – NAD-dependent deacetylase SIRT2 – histone NADC – nicotinamide adenine dinucleotide-dependent histone deacetylase – NAD-dependent deacetylase sirtuin 2 homolog – SRT2 (SIRTUIN 2); DNA binding / NAD or NADH binding / NAD-dependent histone deacetylase/ zinc ion binding – sirtuin (silent mating type information regulation 2 homolog) 2

Sirtuin 2 erfüllt eine Reihe von Funktionen:

NAD binding – NAD+ ADP-ribosyltransferase activity – NAD-dependent histone deacetylase activity – histone acetyltransferase binding – histone deacetylase binding – hydrolase activity – metal ion binding – transcription factor binding – tubulin deacetylase activity – ubiquitin binding – zinc ion binding – NAD or NADH binding – hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides – molecular_function – protein binding – protein deacetylase activity – DNA binding

Sirtuin 2 spielt in den folgenden Prozessen eine Rolle:

cell cycle – cell division – chromatin silencing at rDNA – chromatin silencing at telomere – histone deacetylation – mitosis – negative regulation of striated muscle tissue development – negative regulation of transcription – protein amino acid ADP-ribosylation – redox signal response – regulation of exit from mitosis – regulation of phosphorylation – chromatin silencing – dendrite morphogenesis – protein amino acid deacetylation – regulation of transcription – biological_process – defense response to bacterium – negative regulation of defense response – regulation of transcription, DNA-dependent

Sirtuin 2 ist wie folgt lokalisiert:

chromatin silencing complex – cytoplasm – cytoskeleton – microtubule – cellular_component – nucleus

Quelle: NCBI Entrez Gene, Gene Ontology