Die folgenden Gennamen und Gensymbole werden für Antigen Sirtuin 1 über verschiedene Spezies hinweg verwendet:

sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) (SIRT1), SRT1 (sirtuin 1); DNA binding / NAD or NADH binding / NAD-dependent histone deacetylase/ zinc ion binding (SRT1), sirtuin 1 (LOC100349271), sirtuin 1 (SIRT1)

Zu den weiteren Synonymen zählen:

SIR2L1, SIRT1, SIR2, sirtuin 1, SRT1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Sirtuin 1 auf:

sirtuin 1 – SIR2alpha – sir2-like 1 – sirtuin type 1 – SIR2-like protein 1 – NAD-dependent deacetylase sirtuin 1 – sirtuin1 – SRT1 (sirtuin 1); DNA binding / NAD or NADH binding / NAD-dependent histone deacetylase/ zinc ion binding

Sirtuin 1 erfüllt eine Reihe von Funktionen:

NAD binding – NAD+ ADP-ribosyltransferase activity – NAD-dependent histone deacetylase activity – histone binding – hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides – identical protein binding – metal ion binding – p53 binding – protein C-terminus binding – protein domain specific binding – transcription corepressor activity – zinc ion binding – DNA binding

Sirtuin 1 spielt in den folgenden Prozessen eine Rolle:

DNA repair – DNA replication – cell aging – cell differentiation – cellular response to starvation – establishment of chromatin silencing – histone deacetylation – interspecies interaction between organisms – maintenance of chromatin silencing – multicellular organismal development – muscle organ development – negative regulation of DNA damage response, signal transduction by p53 class mediator – negative regulation of fat cell differentiation – negative regulation of helicase activity – negative regulation of transcription – negative regulation of transcription factor activity – ovulation from ovarian follicle – peptidyl-lysine deacetylation – positive regulation of anti-apoptosis – positive regulation of chromatin silencing – protein amino acid ADP-ribosylation – regulation of apoptosis – regulation of cell proliferation – regulation of protein import into nucleus, translocation – regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor – response to DNA damage stimulus – spermatogenesis – triglyceride mobilization – white fat cell differentiation – chromatin silencing – protein deacetylation – regulation of transcription – regulation of transcription, DNA-dependent

Sirtuin 1 ist wie folgt lokalisiert:

PML body – cytoplasm – nuclear envelope – nucleolus – nucleus – chromatin silencing complex

Quelle: NCBI Entrez Gene, Gene Ontology