Die folgenden Gennamen und Gensymbole werden für Antigen Sequestosome 1 über verschiedene Spezies hinweg verwendet:

sequestosome 1 (SQSTM1), sequestosome 1 (Sqstm1), sequestosome 1 (sqstm1), sequestosome 1 (LOC100342157), sqstm1 protein (sqstm1)

Zu den weiteren Synonymen zählen:

p60, p62, A170, OSIL, PDB3, ZIP3, p62B, Osi, STAP, OSF-6, SQSTM1, MGC127197, MGC64432, sb:cb621, zgc:85784, DKFZp468L2213, sqstm1, MGC79491

Auf Proteinebene tauchen folgende Bezeichner für Antigen Sequestosome 1 auf:

sequestosome 1 – EBI3-associated protein p60 – oxidative stress induced like – ubiquitin-binding protein p62 – phosphotyrosine independent ligand for the Lck SH2 domain p62 – sequestosome-1 – STONE14 – OTTMUSP00000005735 – OTTMUSP00000005736 – OTTMUSP00000046654 – oxidative stress induced – Sequestosome 1 – Sequestosome-1 – sequestosome-1-like – sqstm1 protein

Sequestosome 1 erfüllt eine Reihe von Funktionen:

SH2 domain binding – metal ion binding – protein binding – protein kinase C binding – receptor tyrosine kinase binding – ubiquitin binding – zinc ion binding – transcription cofactor activity

Sequestosome 1 spielt in den folgenden Prozessen eine Rolle:

anti-apoptosis – apoptosis – cell differentiation – endosome transport – immune response – induction of apoptosis by extracellular signals – intracellular signaling cascade – positive regulation of transcription from RNA polymerase II promoter – protein localization – regulation of I-kappaB kinase/NF-kappaB cascade – response to stress – ubiquitin-dependent protein catabolic process – positive regulation of protein amino acid phosphorylation – protein heterooligomerization – regulation of transcription – biological_process

Sequestosome 1 ist wie folgt lokalisiert:

cytoplasm – cytosol – late endosome – nucleoplasm – nucleus – endosome – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology