Die folgenden Gennamen und Gensymbole werden für Antigen SMAD, Mothers Against DPP Homolog 1 über verschiedene Spezies hinweg verwendet:

SMAD family member 1 (SMAD1), SMAD family member 1 (Smad1), SMAD family member 1 (smad1)

Zu den weiteren Synonymen zählen:

BSP1, JV41, JV4-1, MADH1, MADR1, Madh1, bsp1, jv41, Xmad1, jv4-1, madh1, madr1, Xsmad1, smad-1, MGC89254, SMAD1, MGC138917

Auf Proteinebene tauchen folgende Bezeichner für Antigen SMAD, Mothers Against DPP Homolog 1 auf:

Sma- and Mad-related protein 1 – Mad-related protein 1 – TGF-beta signaling protein 1 – mothers against DPP homolog 1 – SMAD, mothers against DPP homolog 1 – MAD, mothers against decapentaplegic homolog 1 – transforming growth factor-beta signaling protein 1 – mothers against decapentaplegic homolog 1 – SMAD 1 – MAD homolog 1 – MAD homolog1 (mothers against decapentaplegic, Drosophila) – MAD (mothers against decapentaplegic, Drosophila) homolog 1 – BMP pathway effector – BMP signal transducer Smad1 – SMAD family member 1 – mad-related protein 1 – mothers against decapentaplegic-like protein 1

SMAD, Mothers Against DPP Homolog 1 erfüllt eine Reihe von Funktionen:

RNA polymerase II transcription factor activity – co-SMAD binding – identical protein binding – protein kinase binding – receptor signaling protein activity – transcription activator activity – transcription factor activity – transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity – I-SMAD binding – protein binding – sequence-specific DNA binding transcription factor activity

SMAD, Mothers Against DPP Homolog 1 spielt in den folgenden Prozessen eine Rolle:

BMP signaling pathway – MAPKKK cascade – SMAD protein complex assembly – embryonic pattern specification – gamete generation – hindbrain development – homeostatic process – inflammatory response – mesodermal cell fate commitment – midbrain development – negative regulation of cell proliferation – osteoblast fate commitment – positive regulation of gene expression – positive regulation of osteoblast differentiation – positive regulation of transcription from RNA polymerase II promoter – primary microRNA processing – signal transduction – transforming growth factor beta receptor signaling pathway – cellular response to organic cyclic substance – kidney development – positive regulation of anti-apoptosis – positive regulation of cartilage development – positive regulation of cell differentiation – positive regulation of dendrite morphogenesis – positive regulation of gene-specific transcription from RNA polymerase II promoter – protein amino acid phosphorylation – regulation of transcription from RNA polymerase II promoter – response to drug – response to organic nitrogen – ureteric bud development – wound healing

SMAD, Mothers Against DPP Homolog 1 ist wie folgt lokalisiert:

cytoplasm – cytosol – integral to membrane – intracellular – nucleoplasm – nucleus – transcription factor complex – nuclear inner membrane

Quelle: NCBI Entrez Gene, Gene Ontology