Die folgenden Gennamen und Gensymbole werden für Antigen SMAD, Mothers Against DPP Homolog 7 über verschiedene Spezies hinweg verwendet:

SMAD family member 7 (SMAD7)

Zu den weiteren Synonymen zählen:

CRCS3, MADH7, MADH8, FLJ16482, Smad7a

Auf Proteinebene tauchen folgende Bezeichner für Antigen SMAD, Mothers Against DPP Homolog 7 auf:

SMAD family member 7 – SMAD, mothers against DPP homolog 7 – MAD, mothers against decapentaplegic homolog 7 – Mothers against decapentaplegic, drosophila, homolog of, 7 – MAD (mothers against decapentaplegic, Drosophila) homolog 7

SMAD, Mothers Against DPP Homolog 7 erfüllt eine Reihe von Funktionen:

I-SMAD binding – activin binding – beta-catenin binding – collagen binding – promoter binding – transcription factor activity – transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity – type I transforming growth factor beta receptor binding – ubiquitin protein ligase binding – protein binding

SMAD, Mothers Against DPP Homolog 7 spielt in den folgenden Prozessen eine Rolle:

adherens junction assembly – artery morphogenesis – cellular protein complex localization – negative regulation of BMP signaling pathway – negative regulation of cell migration – negative regulation of epithelial to mesenchymal transition – negative regulation of gene-specific transcription from RNA polymerase II promoter – negative regulation of pathway-restricted SMAD protein phosphorylation – negative regulation of peptidyl-serine phosphorylation – negative regulation of peptidyl-threonine phosphorylation – negative regulation of protein ubiquitination – negative regulation of transcription by competitive promoter binding – negative regulation of transcription factor activity – negative regulation of ubiquitin-protein ligase activity – positive regulation of anti-apoptosis – positive regulation of cell-cell adhesion – positive regulation of proteasomal ubiquitin-dependent protein catabolic process – positive regulation of protein ubiquitination – protein stabilization – regulation of activin receptor signaling pathway – regulation of transcription, DNA-dependent – regulation of ventricular cardiomyocyte membrane depolarization – response to laminar fluid shear stress – ventricular cardiac muscle morphogenesis – ventricular septum morphogenesis – transforming growth factor beta receptor signaling pathway

SMAD, Mothers Against DPP Homolog 7 ist wie folgt lokalisiert:

catenin complex – cell-cell adherens junction – cytoplasm – cytosol – intracellular – nucleus – plasma membrane – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology