Die folgenden Gennamen und Gensymbole werden für Antigen SMAD, Mothers Against DPP Homolog 4 über verschiedene Spezies hinweg verwendet:

SMAD family member 4 (SMAD4)

Zu den weiteren Synonymen zählen:

JIP, DPC4, MADH4, SMAD4

Auf Proteinebene tauchen folgende Bezeichner für Antigen SMAD, Mothers Against DPP Homolog 4 auf:

mothers against decapentaplegic homolog 4 – OTTHUMP00000163548 – SMAD, mothers against DPP homolog 4 – deleted in pancreatic carcinoma locus 4 – MAD, mothers against decapentaplegic homolog 4 – mothers against decapentaplegic, Drosophila, homolog of, 4 – SMAD family member 4 – mothers against decapentaplegic-like 4

SMAD, Mothers Against DPP Homolog 4 erfüllt eine Reihe von Funktionen:

R-SMAD binding – collagen binding – promoter binding – protein homodimerization activity – transcription activator activity – transcription factor activity – transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

SMAD, Mothers Against DPP Homolog 4 spielt in den folgenden Prozessen eine Rolle:

BMP signaling pathway – SMAD protein complex assembly – SMAD protein signal transduction – anterior/posterior pattern formation – branching involved in ureteric bud morphogenesis – gastrulation with mouth forming second – kidney development – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of transcription, DNA-dependent – neuron fate commitment – palate development – positive regulation of SMAD protein nuclear translocation – positive regulation of epithelial to mesenchymal transition – positive regulation of pathway-restricted SMAD protein phosphorylation – positive regulation of transcription from RNA polymerase II promoter – regulation of binding – regulation of transforming growth factor beta receptor signaling pathway – regulation of transforming growth factor-beta2 production – response to hypoxia

SMAD, Mothers Against DPP Homolog 4 ist wie folgt lokalisiert:

activin responsive factor complex – cytoplasm – cytosol – intracellular – nucleoplasm – nucleus

Quelle: NCBI Entrez Gene, Gene Ontology