Die folgenden Gennamen und Gensymbole werden für Antigen SMAD, Mothers Against DPP Homolog 3 über verschiedene Spezies hinweg verwendet:

SMAD family member 3 (SMAD3)

Zu den weiteren Synonymen zählen:

MADH3, JV15-2, HSPC193, HsT17436, MGC60396, DKFZp586N0721, DKFZp686J10186

Auf Proteinebene tauchen folgende Bezeichner für Antigen SMAD, Mothers Against DPP Homolog 3 auf:

mothers against decapentaplegic homolog 3 – mad homolog JV15-2 – mad protein homolog – SMA- and MAD-related protein 3 – SMAD, mothers against DPP homolog 3 – MAD, mothers against decapentaplegic homolog 3 – TGF beta response effector Smad3 – TGF-beta response effector Smad3

SMAD, Mothers Against DPP Homolog 3 erfüllt eine Reihe von Funktionen:

R-SMAD binding – co-SMAD binding – collagen binding – double-stranded DNA binding – promoter binding – protein homodimerization activity – protein kinase binding – transcription activator activity – transcription factor activity – transcription factor binding – transforming growth factor beta receptor binding – transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity – transport accessory protein activity – ubiquitin protein ligase binding – protein binding

SMAD, Mothers Against DPP Homolog 3 spielt in den folgenden Prozessen eine Rolle:

SMAD protein complex assembly – T cell activation – activation of caspase activity – cell cycle arrest – cell-cell junction organization – evasion of host defenses by virus – induction of apoptosis – mesoderm formation – negative regulation of cell growth – negative regulation of mitotic cell cycle – negative regulation of osteoblast differentiation – negative regulation of transcription from RNA polymerase II promoter – osteoblast development – paraxial mesoderm morphogenesis – positive regulation of epithelial to mesenchymal transition – positive regulation of transcription factor import into nucleus – positive regulation of transcription from RNA polymerase II promoter – primary microRNA processing – regulation of binding – regulation of epithelial cell proliferation – regulation of immune response – regulation of striated muscle tissue development – regulation of transforming growth factor beta receptor signaling pathway – regulation of transforming growth factor-beta2 production – response to hypoxia – wound healing – regulation of transcription, DNA-dependent – transforming growth factor beta receptor signaling pathway

SMAD, Mothers Against DPP Homolog 3 ist wie folgt lokalisiert:

cytoplasm – cytosol – intracellular – nucleoplasm – nucleus – plasma membrane – receptor complex – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology