Die folgenden Gennamen und Gensymbole werden für Antigen SMAD, Mothers Against DPP Homolog 2 über verschiedene Spezies hinweg verwendet:

SMAD family member 2 (SMAD2), SMAD family member 2 (smad2)

Zu den weiteren Synonymen zählen:

JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, MGC22139, MGC34440, SMAD2, jv18, Xmad2, madh2, madr2, XSmad2, hmad-2, hsmad2, jv18-1, smad-2

Auf Proteinebene tauchen folgende Bezeichner für Antigen SMAD, Mothers Against DPP Homolog 2 auf:

Sma- and Mad-related protein 2 – Mad protein homolog – Mad-related protein 2 – mother against DPP homolog 2 – SMAD, mothers against DPP homolog 2 – MAD, mothers against decapentaplegic homolog 2 – Mad, mothers against decapentaplegic homolog 2 – SMAD family member 2

SMAD, Mothers Against DPP Homolog 2 erfüllt eine Reihe von Funktionen:

R-SMAD binding – co-SMAD binding – double-stranded DNA binding – promoter binding – transcription activator activity – transcription factor activity – transcription factor binding – transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity – type I transforming growth factor beta receptor binding – ubiquitin protein ligase binding – protein binding – collagen binding

SMAD, Mothers Against DPP Homolog 2 spielt in den folgenden Prozessen eine Rolle:

SMAD protein complex assembly – anterior/posterior pattern formation – cell fate commitment – gastrulation – intracellular signaling cascade – mesoderm formation – negative regulation of transcription, DNA-dependent – palate development – paraxial mesoderm morphogenesis – positive regulation of epithelial to mesenchymal transition – positive regulation of gene-specific transcription – positive regulation of transcription from RNA polymerase II promoter – primary microRNA processing – regulation of binding – regulation of transforming growth factor beta receptor signaling pathway – response to cholesterol – zygotic determination of dorsal/ventral axis – regulation of transcription, DNA-dependent – transforming growth factor beta receptor signaling pathway – T cell activation – negative regulation of osteoblast differentiation – negative regulation of transcription from RNA polymerase II promoter – osteoblast development – regulation of epithelial cell proliferation – regulation of immune response – regulation of striated muscle tissue development

SMAD, Mothers Against DPP Homolog 2 ist wie folgt lokalisiert:

activin responsive factor complex – cytoplasm – cytosol – intracellular – nucleoplasm – nucleus – transcription factor complex – plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology