Die folgenden Gennamen und Gensymbole werden für Antigen Retinoblastoma 1 über verschiedene Spezies hinweg verwendet:

retinoblastoma 1 (RB1), retinoblastoma 1 (Rb1), retinoblastoma 1 (including osteosarcoma) (RB1), retinoblastoma 1 (including osteosarcoma) (LOC100217687), Retinoblastoma-associated protein (rb)

Zu den weiteren Synonymen zählen:

RB, pRb, OSRC, pp110, p105-Rb, Rb, Rb-1, RB1, RB11, PP110, P105-RB

Auf Proteinebene tauchen folgende Bezeichner für Antigen Retinoblastoma 1 auf:

retinoblastoma 1 – retinoblastoma-associated protein – retinoblastoma suspectibility protein – pp105 – rb – pRb – Retinoblastoma 1 (including osteosarcoma) – p104 – retinoblastoma 1 (including osteosarcoma) – retinoblastoma protein 1 – retinoblastoma protein – Retinoblastoma-associated protein – retinoblastoma-associated protein-like

Retinoblastoma 1 erfüllt eine Reihe von Funktionen:

androgen receptor binding – kinase binding – phosphoprotein binding – transcription coactivator activity – transcription factor activity – transcription factor binding – transcription repressor activity – ubiquitin protein ligase binding – DNA binding – protein binding

Retinoblastoma 1 spielt in den folgenden Prozessen eine Rolle:

G1 phase – M phase – androgen receptor signaling pathway – cell cycle arrest – cell cycle checkpoint – cell division – chromatin remodeling – enucleate erythrocyte differentiation – interspecies interaction between organisms – myoblast differentiation – negative regulation of S phase of mitotic cell cycle – negative regulation of cell cycle – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of protein kinase activity – negative regulation of transcription from RNA polymerase II promoter – positive regulation of macrophage differentiation – positive regulation of transcription from RNA polymerase II promoter – regulation of lipid kinase activity – regulation of transcription of G1/S-phase of mitotic cell cycle – striated muscle cell differentiation – G1/S transition of mitotic cell cycle – cell cycle – chromatin modification – negative regulation of transcription, DNA-dependent – regulation of cell cycle – regulation of transcription – transcription – Ras protein signal transduction – negative regulation of transcription

Retinoblastoma 1 ist wie folgt lokalisiert:

PML body – Rb-E2F complex – SWI/SNF complex – chromatin – nucleoplasm – nucleus – spindle – transcription factor complex

Quelle: NCBI Entrez Gene, Gene Ontology