Die folgenden Gennamen und Gensymbole werden für Antigen RAD50 Homolog (S. Cerevisiae) über verschiedene Spezies hinweg verwendet:

RAD50 homolog (S. cerevisiae) (RAD50), RAD50 homolog (S. cerevisiae) (Rad50), rad50 (rad50), RAD50 homolog (rad50), DNA repair protein RAD50 (rad50), RAD50; ATP binding / nuclease/ zinc ion binding (RAD50), Rad50p (RAD50), DNA repair protein Rad50 (SPAP4C9.01c), Rad50 DNA repair/recombination protein (RAD50), Rad50 DNA repair/recombination protein (Rad50)

Zu den weiteren Synonymen zählen:

hRad50, RAD50-2, Mrell, Rad50l, Dmrad50, RAD50, DmelCG6339, CG6339, ATRAD50, DNA REPAIR-RECOMBINATION PROTEIN, F22D22.28, F22D22_28, rad50

Auf Proteinebene tauchen folgende Bezeichner für Antigen RAD50 Homolog (S. Cerevisiae) auf:

RAD50 homolog – DNA repair protein RAD50 – mRad50 – OTTMUSP00000005819 – rad50 – CG6339-PC – rad50-PC – RAD50 homolog (S. cerevisiae) – GLEAN_15093 – RAD50; ATP binding / nuclease/ zinc ion binding – Rad50p – Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining – DNA repair protein Rad50 – Rad50 DNA repair/recombination protein – RAD50 recombination protein – DNA repair protein RAD50-like

RAD50 Homolog (S. Cerevisiae) erfüllt eine Reihe von Funktionen:

3'-5' exonuclease activity – ATP binding – DNA binding – hydrolase activity – metal ion binding – nuclease activity – nucleotide binding – protein binding, bridging – single-stranded DNA specific endodeoxyribonuclease activity – zinc ion binding – ATP-dependent DNA helicase activity – protein binding – ATPase activity – G-quadruplex DNA binding – adenylate kinase activity – double-stranded DNA binding – double-stranded telomeric DNA binding – single-stranded telomeric DNA binding – telomeric DNA binding

RAD50 Homolog (S. Cerevisiae) spielt in den folgenden Prozessen eine Rolle:

cell cycle – double-strand break repair – meiosis – reciprocal meiotic recombination – regulation of mitotic recombination – response to DNA damage stimulus – telomere maintenance – telomere maintenance via telomerase – DNA repair – protein heterooligomerization – cellular response to DNA damage stimulus – chromosome organization – instar larval development – telomere capping – DNA duplex unwinding – DNA recombination – cell cycle checkpoint – positive regulation of kinase activity – positive regulation of protein amino acid autophosphorylation – mitotic recombination – base-excision repair – double-strand break repair via break-induced replication – double-strand break repair via nonhomologous end joining – meiotic DNA double-strand break formation – meiotic DNA double-strand break processing – meiotic cell cycle – negative regulation of endodeoxyribonuclease activity – sporulation resulting in formation of a cellular spore – telomere maintenance via recombination – DNA damage checkpoint – double-strand break repair via homologous recombination – gene conversion at mating-type locus, DNA repair synthesis – intra-S DNA damage checkpoint

RAD50 Homolog (S. Cerevisiae) ist wie folgt lokalisiert:

Mre11 complex – chromosome – nuclear chromosome, telomeric region – pronucleus – chromosome, telomeric region – condensed nuclear chromosome – inclusion body – nuclear chromatin – nucleoplasm – nucleus – perinuclear region of cytoplasm – cytoplasm – chromosomal part – mitochondrion

Quelle: NCBI Entrez Gene, Gene Ontology