Die folgenden Gennamen und Gensymbole werden für Antigen Protein Kinase C, alpha über verschiedene Spezies hinweg verwendet:

protein kinase C, alpha (PRKCA), protein kinase C, alpha (Prkca), protein kinase C, alpha (RCJMB04_5a10), protein kinase C, alpha (prkca), protein kinase C, alpha (LOC100219195)

Zu den weiteren Synonymen zählen:

AAG6, PKCA, PRKACA, MGC129900, MGC129901, PKC-alpha, Pkca, AI875142, PRKCA, PKRCA, prkca, MGC82897, im:7139045, si:dkey-8l19.1, pkcalpha, MGC146825, pkc-alpha, LOC100219195

Auf Proteinebene tauchen folgende Bezeichner für Antigen Protein Kinase C, alpha auf:

protein kinase C, alpha – aging-associated gene 6 – protein kinase C alpha type – OTTMUSP00000003037 – protein kinase c-alpha – PKC-alpha – protein kinase, C alpha – protein kinase C alpha type-like – protein kinase C alpha

Protein Kinase C, alpha erfüllt eine Reihe von Funktionen:

ATP binding – calcium ion binding – calcium-dependent protein kinase C activity – diacylglycerol binding – nucleotide binding – protein binding – transferase activity – zinc ion binding – kinase activity – metal ion binding – protein kinase C activity – protein kinase activity – protein serine/threonine kinase activity

Protein Kinase C, alpha spielt in den folgenden Prozessen eine Rolle:

cellular calcium ion homeostasis – chondrocyte differentiation – inactivation of MAPK activity – induction of apoptosis by extracellular signals – induction of apoptosis by intracellular signals – induction of positive chemotaxis – intracellular signaling cascade – negative regulation of cell proliferation – negative regulation of glucose import – negative regulation of insulin receptor signaling pathway – negative regulation of protein amino acid phosphorylation – negative regulation of protein kinase activity – neutrophil chemotaxis – positive regulation of inflammatory response – positive regulation of protein amino acid phosphorylation – regulation of muscle contraction – regulation of peptidyl-tyrosine phosphorylation – regulation of the force of heart contraction – response to interleukin-1 – protein amino acid phosphorylation – aging – central nervous system neuron axonogenesis – establishment of protein localization – learning or memory – negative regulation of heart contraction – negative regulation of translation – peptidyl-serine phosphorylation – peptidyl-threonine phosphorylation – positive regulation of exocytosis – positive regulation of smooth muscle cell proliferation – positive regulation of synaptogenesis – regulation of receptor-mediated endocytosis – response to antibiotic – response to corticosterone stimulus – response to estradiol stimulus – response to ethanol – response to mechanical stimulus – response to organic cyclic substance – response to peptide hormone stimulus – response to reactive oxygen species – response to toxin

Protein Kinase C, alpha ist wie folgt lokalisiert:

cytoplasm – cytosol – extrinsic to membrane – membrane fraction – mitochondrion – nucleus – plasma membrane – membrane – membrane raft – protein complex – synaptosome – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology