Die folgenden Gennamen und Gensymbole werden für Antigen Protein Kinase B über verschiedene Spezies hinweg verwendet:

thymoma viral proto-oncogene 1 (Akt1), v-akt murine thymoma viral oncogene homolog 1 (AKT1), PTK2B protein tyrosine kinase 2 beta (PTK2B), v-akt murine thymoma viral oncogene homolog 1 (Akt1)

Zu den weiteren Synonymen zählen:

Akt, PKB, Rac, PKB/Akt, PKBalpha, AKT, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHA, PTK, CAKB, FAK2, FRNK, PYK2, CADTK, FADK2, RAFTK

Auf Proteinebene tauchen folgende Bezeichner für Antigen Protein Kinase B auf:

AKT1 kinase – OTTMUSP00000022944 – OTTMUSP00000022949 – protein kinase B-alpha – related to A and C kinases – RAC-alpha serine/threonine-protein kinase – protein kinase B – rac protein kinase alpha – PTK2B protein tyrosine kinase 2 beta – CAK beta – focal adhesion kinase 2 – cell adhesion kinase beta – proline-rich tyrosine kinase 2 – protein tyrosine kinase 2 beta – calcium-dependent tyrosine kinase – related adhesion focal tyrosine kinase – PKB – RAC-PK-alpha – thymoma viral proto-oncogene 1 – RAC protein kinase alpha RAC-PK alpha – murine thymoma viral (v-akt) oncogene homolog 1

Protein Kinase B erfüllt eine Reihe von Funktionen:

ATP binding – kinase activity – nucleotide binding – protein binding – protein kinase activity – protein serine/threonine kinase activity – transferase activity – enzyme binding – identical protein binding – nitric-oxide synthase regulator activity – phosphatidylinositol-3,4,5-trisphosphate binding – phosphatidylinositol-3,4-bisphosphate binding – non-membrane spanning protein tyrosine kinase activity – signal transducer activity

Protein Kinase B spielt in den folgenden Prozessen eine Rolle:

activation-induced cell death of T cells – anagen – apoptosis – apoptotic mitochondrial changes – carbohydrate metabolic process – carbohydrate transport – cell projection organization – cellular response to insulin stimulus – germ cell development – glucose metabolic process – glucose transport – glycogen biosynthetic process – glycogen cell development involved in embryonic placenta development – glycogen metabolic process – inflammatory response – insulin receptor signaling pathway – intracellular signaling cascade – labyrinthine layer blood vessel development – maternal placenta development – negative regulation of apoptosis – negative regulation of cell size – peptidyl-serine phosphorylation – positive regulation of proteasomal ubiquitin-dependent protein catabolic process – positive regulation of sodium ion transport – protein amino acid phosphorylation – protein catabolic process – protein kinase B signaling cascade – protein ubiquitination – regulation of protein localization – regulation of survival gene product expression – regulation of translation – response to food – response to hormone stimulus – transport – G-protein coupled receptor protein signaling pathway – activation of pro-apoptotic gene products – blood vessel development – insulin-like growth factor receptor signaling pathway – negative regulation of fatty acid beta-oxidation – negative regulation of plasma membrane long-chain fatty acid transport – negative regulation of protein kinase activity – placenta development – positive regulation of cell growth – positive regulation of cellular protein metabolic process – positive regulation of cyclin-dependent protein kinase activity during G1/S – positive regulation of fat cell differentiation – positive regulation of glucose import – positive regulation of glucose metabolic process – positive regulation of glycogen biosynthetic process – positive regulation of lipid biosynthetic process – positive regulation of multicellular organism growth – positive regulation of nitric oxide biosynthetic process – positive regulation of nitric-oxide synthase activity – protein amino acid autophosphorylation – protein import into nucleus, translocation – protein modification process – regulation of establishment of protein localization – response to UV-A – response to fluid shear stress – response to heat – positive regulation of cell proliferation – protein complex assembly – response to stress – signal complex assembly – signal transduction – anti-apoptosis – intracellular signaling pathway – negative regulation of JNK cascade – nervous system development – phosphorylation – positive regulation of cyclin-dependent protein kinase activity involved in G1/S – positive regulation of establishment of protein localization in plasma membrane – regulation of cell migration – regulation of glycogen biosynthetic process – regulation of neuron projection development – translation

Protein Kinase B ist wie folgt lokalisiert:

cytoplasm – cytosol – lamellipodium – membrane – nucleus – plasma membrane – spindle – cytoskeleton – nucleoplasm – focal adhesion – microtubule cytoskeleton – soluble fraction

Quelle: NCBI Entrez Gene, Gene Ontology