Die folgenden Gennamen und Gensymbole werden für Antigen Proprotein Convertase Subtilisin/kexin Type 9 über verschiedene Spezies hinweg verwendet:

proprotein convertase subtilisin/kexin type 9 (PCSK9), proprotein convertase subtilisin/kexin type 9 (pcsk9), proprotein convertase subtilisin/kexin type 9 (Pcsk9)

Zu den weiteren Synonymen zählen:

FH3, NARC1, LDLCQ1, NARC-1, HCHOLA3, PCSK9, PC9, Narc1, AI415265, AI747682, MGC47409

Auf Proteinebene tauchen folgende Bezeichner für Antigen Proprotein Convertase Subtilisin/kexin Type 9 auf:

proprotein convertase subtilisin/kexin type 9 – neural apoptosis regulated convertase 1 – convertase subtilisin/kexin type 9 preproprotein – proprotein convertase subtilisin/kexin type 9 preproprotein – NARC-1 – OTTMUSP00000008554 – convertase subtilisin – proprotein convertase 9 – proprotein convertase PC9 – subtilisin/kexin-like protease PC9 – neural apoptosis-regulated convertase 1

Proprotein Convertase Subtilisin/kexin Type 9 erfüllt eine Reihe von Funktionen:

apolipoprotein receptor binding – calcium ion binding – identical protein binding – low-density lipoprotein receptor binding – peptidase activity – serine-type endopeptidase activity – very-low-density lipoprotein receptor binding – hydrolase activity – serine-type peptidase activity

Proprotein Convertase Subtilisin/kexin Type 9 spielt in den folgenden Prozessen eine Rolle:

cellular response to insulin stimulus – cellular response to starvation – cholesterol homeostasis – cholesterol metabolic process – induction of apoptosis – kidney development – lipid metabolic process – lipoprotein metabolic process – liver development – lysosomal transport – negative regulation of catalytic activity – negative regulation of low-density lipoprotein particle clearance – negative regulation of receptor recycling – neurogenesis – neuron differentiation – phospholipid metabolic process – positive regulation of neuron apoptosis – positive regulation of receptor internalization – protein autoprocessing – protein maturation by peptide bond cleavage – proteolysis – regulation of low-density lipoprotein receptor catabolic process – regulation of receptor activity – steroid metabolic process – triglyceride metabolic process – low-density lipoprotein receptor catabolic process – low-density lipoprotein receptor metabolic process

Proprotein Convertase Subtilisin/kexin Type 9 ist wie folgt lokalisiert:

extracellular region – extracellular space – extrinsic to external side of plasma membrane – late endosome – lysosome – perinuclear region of cytoplasm – rough endoplasmic reticulum

Quelle: NCBI Entrez Gene, Gene Ontology