Die folgenden Gennamen und Gensymbole werden für Antigen Promyelocytic Leukemia über verschiedene Spezies hinweg verwendet:

promyelocytic leukemia (PML), promyelocytic leukemia (Pml)

Zu den weiteren Synonymen zählen:

MYL, RNF71, PP8675, TRIM19, Trim19, AI661194, 1200009E24Rik, RGD1562602, PML

Auf Proteinebene tauchen folgende Bezeichner für Antigen Promyelocytic Leukemia auf:

promyelocytic leukemia protein – tripartite motif protein TRIM19 – promyelocytic leukemia, inducer of – probable transcription factor PML – OTTMUSP00000044975 – OTTMUSP00000044976 – OTTMUSP00000044977 – promyelocytic leukemia – probable transcription factor PML-like

Promyelocytic Leukemia erfüllt eine Reihe von Funktionen:

DNA binding – SMAD binding – metal ion binding – protein homodimerization activity – transcription regulator activity – ubiquitin protein ligase binding – zinc ion binding – protein binding – transcription coactivator activity – cobalt ion binding – molecular_function – protein heterodimerization activity – transcription repressor activity

Promyelocytic Leukemia spielt in den folgenden Prozessen eine Rolle:

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest – DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis – PML body organization – SMAD protein nuclear translocation – activation of caspase activity – cell aging – cell cycle arrest – common-partner SMAD protein phosphorylation – induction of apoptosis – interspecies interaction between organisms – maintenance of protein location in nucleus – myeloid cell differentiation – negative regulation of angiogenesis – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of transcription – protein complex assembly – regulation of MHC class I biosynthetic process – response to UV – response to cytokine stimulus – response to gamma radiation – response to hypoxia – retinoic acid receptor signaling pathway – transforming growth factor beta receptor signaling pathway – DNA damage response, signal transduction resulting in induction of apoptosis – branching involved in mammary gland duct morphogenesis – cell fate commitment – positive regulation of transcription – regulation of transcription – transcription – biological_process – negative regulation of mitotic cell cycle – negative regulation of translation in response to oxidative stress – positive regulation of defense response to virus by host – positive regulation of histone deacetylation – protein stabilization – protein targeting

Promyelocytic Leukemia ist wie folgt lokalisiert:

PML body – cytoplasm – insoluble fraction – intracellular – nuclear matrix – nuclear membrane – nucleolus – nucleoplasm – nucleus – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology