Die folgenden Gennamen und Gensymbole werden für Antigen Polycystic Kidney Disease 2 über verschiedene Spezies hinweg verwendet:

polycystic kidney disease 2 (autosomal dominant) (PKD2), polycystic kidney disease 2 (Pkd2), polycystic kidney disease 2 (pkd2)

Zu den weiteren Synonymen zählen:

PC2, PKD4, Pc-2, APKD2, MGC138466, MGC138468, TRPP2, C030034P18Rik

Auf Proteinebene tauchen folgende Bezeichner für Antigen Polycystic Kidney Disease 2 auf:

polycystin 2 – polycystwin – polycystic kidney disease 2 – OTTMUSP00000031741 – cup – TRPP2 – curly up – polycystin-2

Polycystic Kidney Disease 2 erfüllt eine Reihe von Funktionen:

ATPase binding – calcium ion binding – channel activity – cytoskeletal protein binding – ion channel activity – potassium channel activity – protein C-terminus binding – receptor binding – voltage-gated chloride channel activity – voltage-gated sodium channel activity – calcium channel activity – protein binding

Polycystic Kidney Disease 2 spielt in den folgenden Prozessen eine Rolle:

JAK-STAT cascade – calcium ion transport – cation transport – cell cycle arrest – cell-matrix adhesion – cellular calcium ion homeostasis – detection of mechanical stimulus – determination of left/right symmetry – embryonic placenta development – heart development – kidney development – negative regulation of ryanodine-sensitive calcium-release channel activity – organ morphogenesis – regulation of cAMP metabolic process – release of sequestered calcium ion into cytosol – ion transport – transport – heart looping – pronephros development

Polycystic Kidney Disease 2 ist wie folgt lokalisiert:

actin cytoskeleton – integral to membrane – microtubule basal body – motile primary cilium – nonmotile primary cilium – plasma membrane – polycystin complex – cilium – endoplasmic reticulum – membrane – basolateral plasma membrane – lateral plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology