Die folgenden Gennamen und Gensymbole werden für Antigen Pol II über verschiedene Spezies hinweg verwendet:

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (POLR2A), polymerase (RNA) II (DNA directed) polypeptide A (Polr2a), DNA-directed RNA polymerase II subunit RPB1 (EDI_169920), DNA-directed RNA polymerase II subunit RPB1 (CMU_000800), DNA-directed RNA polymerase II subunit RPB1 (SJAG_01713), DNA-directed RNA polymerase II subunit RPB1 (MGYG_01527), RNA polymerase II 33kD subunit (RpII33), RNA polymerase II 140kD subunit (RpII140), RNA polymerase II 15kD subunit (RpII15), RNA polymerase II 18kD subunit (RpII18)

Zu den weiteren Synonymen zählen:

RPB1, RPO2, POLR2, POLRA, RPBh1, RPOL2, RpIILS, hsRPB1, hRPB220, MGC75453, Rpb1, 220kDa, Rpo2-1, 152117_at, BG:DS00941.10, Pol II, PolII, PolIIo, RNA Pol II, RNA polII, RNAP, RPB3, Rpll33, br17, l(2)34Dg, l(2)br17, l(2)k05605, l34Dg, rpII33, DmelCG7885, CG7885, DmRP140, H5, II, Pol IIc, PolIIc, RNA Pol IIc, RNAP II, RNApolII, RP140, RPII140, RpII140[wimp], l(3)RplII140, rpII140/wimp, wimp, DmelCG3180, CG3180, CG3284, DmelCG3284, dRPB9, l(3)88Be, l(3)Z23, pol II, polII, RNA pol II, RPII15, RpII215, BcDNA:RH21608, CG1163, Dm6, DmelCG1163, RpABC14, Rpll18

Auf Proteinebene tauchen folgende Bezeichner für Antigen Pol II auf:

DNA-directed RNA polymerase II A – DNA-directed RNA polymerase II subunit A – RNA-directed RNA polymerase II subunit RPB1 – DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit – DNA-directed RNA polymerase II subunit RPB1 – RNA polymerase II 1 – RNA polymerase II subunit B1 – DNA-directed RNA polymerase III largest subunit – polymerase (RNA) II (DNA directed) polypeptide A – Polymerase (RNA II (DNA directed), large polypeptide – polymerase (RNA) II (DNA directed) polypeptide A, 220kDa – RNA polymerase II 33kD subunit, isoform A – CG7885-PA – RpII33-PA – lethal 17 in the black-reduced region – lethal(2)34Dg – RNA polymerase II – RNA polymerase II 33kD subunit, isoform B – CG7885-PB – RpII33-PB – RNA polymerase II 140kD subunit – CG3180-PA – RpII140-PA – RNA polymerase subunit IIc – subunit IIc of RNA Pol II – RNA polymeraseII-140 kd subunit – 150kDa polypeptide – RNA pol II second largest subunit – RNA polymerase II second largest subunit – RNA polymerase II 15kD subunit – CG3284-PA – RpII15-PA – RNA polymerase II 18kD subunit – CG1163-PA – RpII18-PA – RNA-polymerase ABC 14kD subunit – RNA polymerase II (18-kDa subunit)

Pol II erfüllt eine Reihe von Funktionen:

DNA binding – DNA-directed RNA polymerase activity – RNA-directed RNA polymerase activity – magnesium ion binding – nucleotidyltransferase activity – protein binding – protein kinase activity – transferase activity – ubiquitin protein ligase binding – zinc ion binding – metal ion binding – molecular_function – protein dimerization activity – ribonucleoside binding – transcription regulator activity

Pol II spielt in den folgenden Prozessen eine Rolle:

RNA elongation from RNA polymerase II promoter – nuclear mRNA splicing, via spliceosome – regulation of transcription, DNA-dependent – transcription – transcription initiation from RNA polymerase II promoter – transcription from RNA polymerase II promoter – RNA splicing – biological_process – regulation of transcription

Pol II ist wie folgt lokalisiert:

DNA-directed RNA polymerase II, core complex – nucleolus – nucleoplasm – nucleus – cellular_component

Quelle: NCBI Entrez Gene, Gene Ontology