Die folgenden Gennamen und Gensymbole werden für Antigen Platelet-Derived Growth Factor Receptor alpha über verschiedene Spezies hinweg verwendet:

platelet-derived growth factor alpha polypeptide (PDGFA), platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), platelet derived growth factor receptor, alpha polypeptide (Pdgfra), platelet-derived growth factor alpha a (pdgfaa), platelet derived growth factor receptor, alpha polypeptide (pdgfra), platelet-derived growth factor receptor alpha (PDGFRA), platelet-derived growth factor alpha polypeptide (pdgfa), platelet-derived growth factor receptor, alpha polypeptide (LOC100218386)

Zu den weiteren Synonymen zählen:

PDGF1, PDGF-A, CD140A, PDGFR2, MGC74795, RHEPDGFRA, CD140a, Pdgfr-2, AI115593, PDGFRA, pdgfa, zgc:100777, pdgfra, MGC52594, PDGFR, PDGFR-A, PDGFA, pdgf, pdgf1, pdgf-a

Auf Proteinebene tauchen folgende Bezeichner für Antigen Platelet-Derived Growth Factor Receptor alpha auf:

platelet-derived growth factor alpha – PDGF A-chain – platelet-derived growth factor alpha chain – platelet-derived growth factor alpha isoform 2 preproprotein – platelet-derived growth factor receptor alpha – PDGF-R-alpha – PDGFRA/BCR fusion – CD140 antigen-like family member A – rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein – alpha-type platelet-derived growth factor receptor – PDGF alpha chain – Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha) – platelet-derived growth factor receptor, alpha polypeptide – platelet-derived growth factor alpha a – platelet-derived growth factor alpha polypeptide – tyrosine kinase PDGFR – alpha-type platelet-derived growth factor receptor-like

Platelet-Derived Growth Factor Receptor alpha erfüllt eine Reihe von Funktionen:

cell surface binding – collagen binding – growth factor activity – platelet-derived growth factor binding – platelet-derived growth factor receptor binding – protein heterodimerization activity – protein homodimerization activity – ATP binding – nucleotide binding – platelet-derived growth factor alpha-receptor activity – receptor activity – transferase activity – vascular endothelial growth factor receptor activity – kinase activity – phosphoinositide 3-kinase binding – protein binding – protein kinase activity – protein tyrosine kinase activity – transmembrane receptor protein tyrosine kinase activity

Platelet-Derived Growth Factor Receptor alpha spielt in den folgenden Prozessen eine Rolle:

cell activation – cell-cell signaling – embryonic development – negative chemotaxis – negative regulation of phosphatidylinositol biosynthetic process – negative regulation of platelet activation – platelet-derived growth factor receptor signaling pathway – positive regulation of DNA replication – positive regulation of cell division – positive regulation of cell migration – positive regulation of fibroblast proliferation – regulation of actin cytoskeleton organization – regulation of smooth muscle cell migration – wound healing – extracellular matrix organization – face morphogenesis – in utero embryonic development – lung development – male genitalia development – odontogenesis of dentine-containing tooth – palate development – peptidyl-tyrosine phosphorylation – protein amino acid autophosphorylation – skeletal system morphogenesis – Leydig cell differentiation – adrenal gland development – anatomical structure morphogenesis – estrogen metabolic process – female gonad development – luteinization – organ morphogenesis – positive regulation of cell proliferation – protein amino acid phosphorylation – transmembrane receptor protein tyrosine kinase signaling pathway – vascular endothelial growth factor receptor signaling pathway – multicellular organismal development – actin cytoskeleton organization – angiogenesis – cell projection assembly – lung alveolus development – regulation of peptidyl-tyrosine phosphorylation

Platelet-Derived Growth Factor Receptor alpha ist wie folgt lokalisiert:

cell surface – extracellular region – extracellular space – membrane – platelet dense granule lumen – integral to plasma membrane – plasma membrane – integral to membrane – microvillus

Quelle: NCBI Entrez Gene, Gene Ontology