Die folgenden Gennamen und Gensymbole werden für Antigen Platelet Derived Growth Factor BB über verschiedene Spezies hinweg verwendet:

platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) (PDGFB)

Zu den weiteren Synonymen zählen:

SIS, SSV, PDGF2, c-sis, FLJ12858

Auf Proteinebene tauchen folgende Bezeichner für Antigen Platelet Derived Growth Factor BB auf:

platelet-derived growth factor beta – becaplermin – PDGF, B chain – platelet-derived growth factor 2 – platelet-derived growth factor, B chain – Platelet-derived growth factor, beta polypeptide (oncogene SIS)

Platelet Derived Growth Factor BB erfüllt eine Reihe von Funktionen:

cell surface binding – collagen binding – growth factor activity – platelet-derived growth factor binding – platelet-derived growth factor receptor binding – protein heterodimerization activity – protein homodimerization activity

Platelet Derived Growth Factor BB spielt in den folgenden Prozessen eine Rolle:

actin cytoskeleton organization – cell chemotaxis – cell growth – cell projection assembly – monocyte chemotaxis – negative regulation of cell migration – negative regulation of phosphatidylinositol biosynthetic process – negative regulation of platelet activation – platelet-derived growth factor receptor signaling pathway – positive regulation of DNA replication – positive regulation of MAP kinase activity – positive regulation of blood vessel endothelial cell migration – positive regulation of cell division – positive regulation of chemotaxis – positive regulation of endothelial cell proliferation – positive regulation of fibroblast proliferation – positive regulation of smooth muscle cell migration – regulation of peptidyl-tyrosine phosphorylation – response to hypoxia – response to wounding – substrate-bound cell migration – transforming growth factor beta receptor signaling pathway

Platelet Derived Growth Factor BB ist wie folgt lokalisiert:

cell surface – cytoplasm – extracellular region – membrane – platelet dense granule lumen

Quelle: NCBI Entrez Gene, Gene Ontology