Die folgenden Gennamen und Gensymbole werden für Antigen Plasminogen Activator Inhibitor Type 1 über verschiedene Spezies hinweg verwendet:

serine (or cysteine) peptidase inhibitor, clade E, member 2 (Serpine2), serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1)

Zu den weiteren Synonymen zählen:

PI-7, Pn-1, Spin4, Gdnpn1, SERPINE1, PAI-1

Auf Proteinebene tauchen folgende Bezeichner für Antigen Plasminogen Activator Inhibitor Type 1 auf:

glia-derived nexin – GDN – serpin E2 – protease nexin 1 – protease nexin I – protease nexin PN-1 – peptidase inhibitor 7 – serine protease inhibitor 4 – Glia-derived nexin/protease nexin I – plasminogen activator inhibitor type 1 – serine (or cysteine) proteinase inhibitor, clade E, member 2 – serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Plasminogen Activator Inhibitor Type 1 erfüllt eine Reihe von Funktionen:

glycosaminoglycan binding – heparin binding – peptidase inhibitor activity – protein binding – receptor binding – serine-type endopeptidase inhibitor activity

Plasminogen Activator Inhibitor Type 1 spielt in den folgenden Prozessen eine Rolle:

blood coagulation – cell differentiation – cerebellar granular layer morphogenesis – dense core granule biogenesis – detection of mechanical stimulus involved in sensory perception – embryo implantation – innervation – long-term synaptic potentiation – mating plug formation – negative regulation of blood coagulation – negative regulation of cell growth – negative regulation of cell proliferation – negative regulation of endopeptidase activity – negative regulation of peptidase activity – negative regulation of phosphoinositide 3-kinase cascade – negative regulation of plasminogen activation – negative regulation of platelet activation – negative regulation of platelet aggregation – negative regulation of protein catabolic process – negative regulation of proteolysis – negative regulation of smoothened signaling pathway – negative regulation of sodium ion transport – nervous system development – positive regulation of astrocyte differentiation – positive regulation of neuron projection development – regulation of synaptic transmission, glutamatergic – regulation of timing of cell differentiation – response to radiation – response to wounding – secretion by cell – secretory granule organization – seminal vesicle epithelium development

Plasminogen Activator Inhibitor Type 1 ist wie folgt lokalisiert:

cytosol – extracellular matrix – extracellular region – extracellular region part – extracellular space – extrinsic to external side of plasma membrane – membrane fraction – neuromuscular junction – neuronal cell body – platelet alpha granule

Quelle: NCBI Entrez Gene, Gene Ontology