Die folgenden Gennamen und Gensymbole werden für Antigen Phospholipase A2 über verschiedene Spezies hinweg verwendet:

phospholipase A2, group IB (pancreas) (PLA2G1B), phospholipase A2, group IB, pancreas (Pla2g1b), CG42237 (CG42237), phospholipase B1 (PLB1), phospholipase A2 (Pla2), phospholipase A2 (PLA2)

Zu den weiteren Synonymen zählen:

PLA2, PLA2A, PPLA2, MGC119834, MGC119835, Pla2a, MGC6679, sPLA2IB, C133, CG4346, DmelCG42237, PLB, hPLB, PLB/LIP, GB13351

Auf Proteinebene tauchen folgende Bezeichner für Antigen Phospholipase A2 auf:

phospholipase A2 group IB – phosphatidylcholine 2-acylhydrolase – phospholipase A2 – PLA2-Ib – OTTMUSP00000015569 – OTTMUSP00000015571 – group IB phospholipase A2 – phosphatidylcholine 2-acylhydrolase 1B – phospholipase A2, group 1B – CG42237 – CG42237-PA – phospholipase B1, membrane-associated – phospholipase B – lysophospholipase – OTTHUMP00000200975 – phospholipase B/lipase – allergen Api m 1 – allergen Api m I

Phospholipase A2 erfüllt eine Reihe von Funktionen:

bile acid binding – calcium ion binding – calcium-dependent phospholipase A2 activity – cell surface binding – hydrolase activity – receptor binding – metal ion binding – phospholipase A2 activity – lipase activity – lysophospholipase activity

Phospholipase A2 spielt in den folgenden Prozessen eine Rolle:

actin filament organization – activation of MAPK activity – activation of phospholipase A2 activity – arachidonic acid secretion – cellular response to insulin stimulus – fatty acid biosynthetic process – glucose transport – interleukin-8 production – leukotriene biosynthetic process – multicellular organismal lipid catabolic process – neutrophil chemotaxis – neutrophil mediated immunity – phosphatidylcholine metabolic process – phospholipid metabolic process – positive regulation of DNA replication – positive regulation of NF-kappaB transcription factor activity – positive regulation of calcium ion transport into cytosol – positive regulation of fibroblast proliferation – positive regulation of gene-specific transcription from RNA polymerase II promoter – positive regulation of immune response – positive regulation of protein secretion – protein kinase cascade – signal transduction – cell proliferation – lipid catabolic process – metabolic process – phospholipid catabolic process – response to stress

Phospholipase A2 ist wie folgt lokalisiert:

extracellular region – extracellular space – stored secretory granule – apical plasma membrane – integral to membrane – plasma membrane

Quelle: NCBI Entrez Gene, Gene Ontology