Die folgenden Gennamen und Gensymbole werden für Antigen Phosphatase and Tensin Homolog über verschiedene Spezies hinweg verwendet:

phosphatase and tensin homolog (PTEN), similar to Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1) (LOC731292), phosphatase and tensin homolog (Pten), phosphatase and tensin homolog (pten)

Zu den weiteren Synonymen zählen:

BZS, MHAM, TEP1, MMAC1, PTEN1, 10q23del, MGC11227, AI463227, MGC183880, 2310035O07Rik, A130070J02Rik, B430203M17Rik, Mmac, PTEN, bzs, mham, tep1, mmac1, pten1, Pten

Auf Proteinebene tauchen folgende Bezeichner für Antigen Phosphatase and Tensin Homolog auf:

phosphatase and tensin homolog – mutated in multiple advanced cancers 1 – MMAC1 phosphatase and tensin homolog deleted on chromosome 10 – similar to Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1) – phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN – OTTMUSP00000023423 – protein tyrosine phosphatase and tensin-like protein – phosphatase and tensin homolog deleted on chromosome ten – protein/lipid phosphatase Pten – mutated in multiple advanced cancers – homolog of human mutated in multiple advanced cancers – phosphatase and tensin homolog (mutated in multiple advanced cancers 1)

Phosphatase and Tensin Homolog erfüllt eine Reihe von Funktionen:

PDZ domain binding – hydrolase activity – inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity – lipid binding – magnesium ion binding – phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity – phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity – phosphatidylinositol-3-phosphatase activity – platelet-derived growth factor receptor binding – protein binding – protein serine/threonine phosphatase activity – protein tyrosine phosphatase activity – protein tyrosine/serine/threonine phosphatase activity – inositol or phosphatidylinositol phosphatase activity – phosphatase activity – phosphoprotein phosphatase activity – enzyme binding

Phosphatase and Tensin Homolog spielt in den folgenden Prozessen eine Rolle:

angiogenesis – cardiac muscle tissue development – central nervous system development – endothelial cell migration – induction of apoptosis – inositol phosphate dephosphorylation – lipid metabolic process – negative regulation of apoptosis – negative regulation of cell migration – negative regulation of cell proliferation – negative regulation of focal adhesion formation – negative regulation of protein kinase B signaling cascade – neuron projection development – phosphoinositide dephosphorylation – platelet-derived growth factor receptor signaling pathway – protein amino acid dephosphorylation – regulation of cyclin-dependent protein kinase activity – regulation of protein stability – apoptosis – cell migration – dephosphorylation – heart development – memory – negative regulation of epithelial cell proliferation – negative regulation of focal adhesion assembly – negative regulation of phagocytosis – nervous system development – positive regulation of apoptosis – prostate gland growth – regulation of B cell apoptosis – regulation of cell cycle – regulation of myeloid cell apoptosis – regulation of neuron projection development – aging – canonical Wnt receptor signaling pathway – negative regulation of protein amino acid phosphorylation – positive regulation of transcription factor activity – protein stabilization – response to ATP – response to arsenic – response to drug – response to estradiol stimulus – response to ethanol – response to glucose stimulus – response to inorganic substance – response to nutrient – response to organic cyclic substance – response to organic substance – response to zinc ion

Phosphatase and Tensin Homolog ist wie folgt lokalisiert:

cytoplasm – cytosol – nucleus – mitochondrion

Quelle: NCBI Entrez Gene, Gene Ontology